Diffuse reflectance measurement tool for laparoscopic surgery

Continuous-wave diffuse reflectance or Near Infrared Spectroscopy (NIRS) offers the possibility to perform a preliminary screening of tissue for ischemia or other tissue anomalies. A tool for intracavity NIRS measurements during laparoscopic surgery, developed within the framework of the FP7-IP ARAKNES (Array of Robots Augmenting the KiNematics of Endoluminal Surgery) project, is described. It consists of a probe, that is located on the tip of an appropriately shaped laparoscopic manipulator and then applied to the tissue. Such a probe employs an array of incoherent semiconductor light sources (LEDs) frequency-multiplexed on a single detector using a lock-in technique. The resulting overall tool structure is simple and compact, and allows efficient coupling of the emitted light towards the tissue. The tool has high responsivity and enables fast and accurate measurements. A dataset gathered from in-vivo tissue is presented. The performance both indicates direct applicability of the tool to significant surgical issues (ischemia detection), and clearly indicates the possibility of further miniaturizing the probe head towards catheterized approaches

Photonic band-structure effects in the reflectivity of periodically patterned waveguides

We report sharp resonant features in the reflectivity spectra of semiconductor waveguides patterned with periodic lattices of deep holes. The resonances arise from coupling of incident light to the photonic bands of the lattice. By varying the reflection geometry, large parts of the photonic band structure are determined. A scattering matrix treatment is used to obtain theoretical spectra which agree well with experiment. The waveguide is shown to have an important influence on the band structure, including marked polarization mixing and significant energy up-shifts

Theoretical analysis of the focusing of acoustic waves by two-dimensional sonic crystals

Motivated by a recent experiment on acoustic lenses, we perform numerical calculations based on a multiple scattering technique to investigate the focusing of acoustic waves with sonic crystals formed by rigid cylinders in air. The focusing effects for crystals of various shapes are examined. The dependance of the focusing length on the filling factor is also studied. It is observed that both the shape and filling factor play a crucial role in controlling the focusing. Furthermore, the robustness of the focusing against disorders is studied. The results show that the sensitivity of the focusing behavior depends on the strength of positional disorders. The theoretical results compare favorably with the experimental observations, reported by Cervera, et al. (Phys. Rev. Lett. 88, 023902 (2002)).Comment: 8 figure

Nanophotonic and hydrogel-based diagnostic system for the monitoring of chronic wounds

Chronic wounds present a major healthcare burden, yet most wounds are only assessed superficially, and treatment is rarely based on the analysis of wound biomarkers. This lack of analysis is based on the fact that sampling of wound biomarkers is typically invasive, leading to a disruption of the wound bed while biomarker detection and quantification is performed in a remote laboratory, away from the point of care. Here, we introduce the diagnostic element of a novel theranostic system that can non-invasively sample biomarkers without disrupting the wound and that can perform biomarker quantification at the point of care, on a short timescale. The system is based on a thermally switchable hydrogel scaffold that enhances wound healing through regeneration of the wound tissue and allows the extraction of wound biomarkers non-destructively. We demonstrate the detection of two major biomarkers of wound health, i.e., IL-6 and TNF-α, in human matrix absorbed into the hydrogel dressing. Quantification of the biomarkers directly in the hydrogel is achieved using a chirped guided mode resonant biosensor and we demonstrate biomarker detection within the clinically relevant range of pg/mL to μg/mL concentrations. We also demonstrate the detection of IL-6 and TNF-α at concentration 1 ng/mL in hydrogel dressing absorbed with clinical wound exudate samples. The high sensitivity and the wide dynamic range we demonstrate are both essential for the clinical relevance of our system. Our test makes a major contribution towards the development of a wound theranostic for guided treatment and management of chronic wounds

Modelling of photonic wire Bragg Gratings

Some important properties of photonic wire Bragg grating structures have been investigate. The design, obtained as a generalisation of the full-width gap grating, has been modelled using 3D finite-difference time-domain simulations. Different types of stop-band have been observed. The impact of the grating geometry on the lowest order (longest wavelength) stop-band has been investigated - and has identified deeply indented configurations where reduction of the stop-bandwidth and of the reflectivity occurred. Our computational results have been substantially validated by an experimental demonstration of the fundamental stop-band of photonic wire Bragg gratings fabricated on silicon-on-insulator material. The accuracy of two distinct 2D computational models based on the effective index method has also been studied - because of their inherently much greater rapidity and consequent utility for approximate initial designs. A 2D plan-view model has been found to reproduce a large part of the essential features of the spectral response of full 3D models

Symmetry characterization of eigenstates in opal-based photonic crystals

The complete symmetry characterization of eigenstates in bare opal systems is obtained by means of group theory. This symmetry assignment has allowed us to identify several bands that cannot couple with an incident external plane wave. Our prediction is supported by layer-KKR calculations, which are also performed: the coupling coefficients between bulk modes and externally excited field tend to zero when symmetry properties mismatch.Comment: 7 pages, 5 figures, submitted to Physical Review

Transition metal dichalcogenide dimer nanoantennas for tailored light–matter interactions

Transition metal dichalcogenides have emerged as promising materials for nanophotonic resonators because of their large refractive index, low absorption within a large portion of the visible spectrum, and compatibility with a wide range of substrates. Herein, we use these properties to fabricate WS2 double-pillar nanoantennas in a variety of geometries enabled by the anisotropy in the crystal structure. Using dark-field spectroscopy, we reveal multiple Mie resonances, to which we couple WSe2 monolayer photoluminescence and achieve Purcell enhancement and an increased fluorescence by factors up to 240 for dimer gaps of 150 nm. We introduce postfabrication atomic force microscope repositioning and rotation of dimer nanoantennas, achieving gaps as small as 10 ± 5 nm, which enables a host of potential applications, including strong Purcell enhancement of single-photon emitters and optical trapping, which we study in simulations. Our findings highlight the advantages of using transition metal dichalcogenides for nanophotonics by exploring applications enabled by their properties

Scattering of elastic waves by periodic arrays of spherical bodies

We develop a formalism for the calculation of the frequency band structure of a phononic crystal consisting of non-overlapping elastic spheres, characterized by Lam\'e coefficients which may be complex and frequency dependent, arranged periodically in a host medium with different mass density and Lam\'e coefficients. We view the crystal as a sequence of planes of spheres, parallel to and having the two dimensional periodicity of a given crystallographic plane, and obtain the complex band structure of the infinite crystal associated with this plane. The method allows one to calculate, also, the transmission, reflection, and absorption coefficients for an elastic wave (longitudinal or transverse) incident, at any angle, on a slab of the crystal of finite thickness. We demonstrate the efficiency of the method by applying it to a specific example.Comment: 19 pages, 5 figures, Phys. Rev. B (in press