80 research outputs found
Idling Magnetic White Dwarf in the Synchronizing Polar BY Cam. The Noah-2 Project
Results of a multi-color study of the variability of the magnetic cataclysmic
variable BY Cam are presented. The observations were obtained at the Korean
1.8m and Ukrainian 2.6m, 1.2m and 38-cm telescopes in 2003-2005, 56
observational runs cover 189 hours. The variations of the mean brightness in
different colors are correlated with a slope dR/dV=1.29(4), where the number in
brackets denotes the error estimates in the last digits. For individual runs,
this slope is much smaller ranging from 0.98(3) to 1.24(3), with a mean value
of 1.11(1). Near the maximum, the slope becomes smaller for some nights,
indicating more blue spectral energy distribution, whereas the night-to-night
variability has an infrared character. For the simultaneous UBVRI photometry,
the slopes increase with wavelength from dU/dR=0.23(1) to dI/dR=1.18(1). Such
wavelength dependence is opposite to that observed in non-magnetic cataclysmic
variables, in an agreement to the model of cyclotron emission. The principal
component analysis shows two (with a third at the limit of detection)
components of variablitity with different spectral energy distribution, which
possibly correspond to different regions of emission. The scalegram analysis
shows a highest peak corresponding to the 200-min spin variability, its quarter
and to the 30-min and 8-min QPOs. The amplitudes of all these components are
dependent on wavelength and luminosity state. The light curves were fitted by a
statistically optimal trigonometrical polynomial (up to 4-th order) to take
into account a 4-hump structure. The dependences of these parameters on the
phase of the beat period and on mean brightness are discussed. The amplitude of
spin variations increases with an increasing wavelength and with decreasing
brightnessComment: 30pages, 11figures, accepted in Cent.Eur.J.Phy
Fluxoid dynamics in superconducting thin film rings
We have measured the dynamics of individual magnetic fluxoids entering and
leaving photolithographically patterned thin film rings of the underdoped
high-temperature superconductor BiSrCaCuO, using a
variable sample temperature scanning SQUID microscope. These results can be
qualitatively described using a model in which the fluxoid number changes by
thermally activated nucleation of a Pearl vortex in, and transport of the Pearl
vortex across, the ring wall.Comment: 9 pages, 10 figures, fixed typo
Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury
A proportion of patients infected with severe acute respiratory syndrome coronavirus 2 experience a range of neuropsychiatric symptoms months after infection, including cognitive deficits, depression and anxiety. The mechanisms underpinning such symptoms remain elusive. Recent research has demonstrated that nervous system injury can occur during COVID-19. Whether ongoing neural injury in the months after COVID-19 accounts for the ongoing or emergent neuropsychiatric symptoms is unclear. Within a large prospective cohort study of adult survivors who were hospitalized for severe acute respiratory syndrome coronavirus 2 infection, we analysed plasma markers of nervous system injury and astrocytic activation, measured 6 months post-infection: neurofilament light, glial fibrillary acidic protein and total tau protein. We assessed whether these markers were associated with the severity of the acute COVID-19 illness and with post-acute neuropsychiatric symptoms (as measured by the Patient Health Questionnaire for depression, the General Anxiety Disorder assessment for anxiety, the Montreal Cognitive Assessment for objective cognitive deficit and the cognitive items of the Patient Symptom Questionnaire for subjective cognitive deficit) at 6 months and 1 year post-hospital discharge from COVID-19. No robust associations were found between markers of nervous system injury and severity of acute COVID-19 (except for an association of small effect size between duration of admission and neurofilament light) nor with post-acute neuropsychiatric symptoms. These results suggest that ongoing neuropsychiatric symptoms are not due to ongoing neural injury
Orientation fields of nonlinear biological fibrils by second harmonic generation microscopy
Interleukin-12 can directly induce T-helper 1 responses in interferon-gamma (IFN-gamma) receptor-deficient mice, but requires IFN-gamma signalling to downregulate T-helper 2 responses
An in vivo model of pulmonary granuloma formation around embolized schistosome eggs was investigated as an environment in which to analyse a role for interleukin-12 (IL-12) in the differentiation of T-helper 1 (Th1) and Th2 subsets. Specifically, mice deficient for the interferon-γ receptor (IFN-γR−/–) were used to determine the role for IL-12 in the absence of IFN-γ-mediated signalling. We show that recombinant IL-12 administered to IFN-γR−/– mice caused the up-regulation of mRNA for IFN-γ in lung tissue, and the secretion of abundant IFN-γ by in vitro-cultured lymph node cells in response to egg antigens. This indicates that IL-12 can act independently of IFN-γ to induce the development of Th1 cells. Administration of rIL-12 to wild-type mice markedly reduced the secretion of Th2-associated cytokines, IL-4 and IL-5. However, these cytokines were not dramatically reduced in IFN-γR−/– mice treated with IL-12. We conclude that inhibition of these cytokines by IL-12 is primarily dependent upon effective IFN-γ signalling, although abrogation of T-cell derived IL-10 appeared to be dependent upon IL-12. We also show that increases in mRNA for the β2 subunit of the IL-12 receptor and the p40 subunit of IL-12 after rIL-12 treatment were lower in IFN-γR−/– mice, compared to wild-type mice, indicating that their expression was primarily dependent upon IFN-γ with only a minor role for IL-12
Changes in interleukin 2 and interleukin 4 production in asymptomatic, HIV-seropositive individuals
Genomic Organization and Chromosomal Localization of a New Member of the Murine Interferon-Induced Guanylate-Binding Protein Family
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