548 research outputs found
Application of artificial neural networks to solar infrared Stokes spectra
Inthis paper we have for the first time applied the new Stokes inversion approach of using artificial neural networks to measured Stokes data of a solar pore. We have demonstrated that this method is capable to produce the same
results as other conventional methods, but at a much faster speed
FANCD2 re-expression is associated with glioma grade and chemical inhibition of the Fanconi Anaemia pathway sensitises gliomas to chemotherapeutic agents.
Brain tumours kill more children and adults under 40 than any other cancer. Around half of primary brain tumours are glioblastoma multiforme (GBMs) where treatment remains a significant challenge. GBM survival rates have improved little over the last 40 years, thus highlighting an unmet need for the identification/development of novel therapeutic targets and agents to improve GBM treatment. Using archived and fresh glioma tissue, we show that in contrast to normal brain or benign schwannomas GBMs exhibit re-expression of FANCD2, a key protein of the Fanconi Anaemia (FA) DNA repair pathway, and possess an active FA pathway. Importantly, FANCD2 expression levels are strongly associated with tumour grade, revealing a potential exploitable therapeutic window to allow inhibition of the FA pathway in tumour cells, whilst sparing normal brain tissue. Using several small molecule inhibitors of the FA pathway in combination with isogenic FA-proficient/deficient glioma cell lines as well as primary GBM cultures, we demonstrate that inhibition of the FA pathway sensitises gliomas to the chemotherapeutic agents Temozolomide and Carmustine. Our findings therefore provide a strong rationale for the development of novel and potent inhibitors of the FA pathway to improve the treatment of GBMs, which may ultimately impact on patient outcome
Abundance analysis, spectral variability, and search for the presence of a magnetic field in the typical PGa star HD 19400
The aim of this study is to carry out an abundance determination, to search for spectral variability and for the presence of a weak magnetic field in the typical PGa star HD 19400. High-resolution, high signal-to-noise High Accuracy Radial-velocity Planet Searcher (HARPS) spectropolarimetric observations of HD 19400 were obtained at three different epochs in 2011 and 2013. For the first time, we present abundances of various elements determined using an ATLAS12 model, including the abundances of a number of elements not analysed by previous studies, such as Ne I, Ga II, and Xe II. Several lines of As II are also present in the spectra of HD 19400. To study the variability, we compared the behaviour of the line profiles of various elements. We report on the first detection of anomalous shapes of line profiles belonging to Mn and Hg, and the variability of the line profiles belonging to the elements Hg, P, Mn, Fe, and Ga. We suggest that the variability of the line profiles of these elements is caused by their non-uniform surface distribution, similar to the presence of chemical spots detected in HgMn stars. The search for the presence of a magnetic field was carried out using the moment technique and the Singular Value Decomposition (SVD) method. Our measurements of the magnetic field with the moment technique using 22 Mn II lines indicate the potential existence of a weak variable longitudinal magnetic field on the first epoch. The SVD method applied to the Mn II lines indicates <Bz> = -76 ± 25 G on the first epoch, and at the same epoch the SVD analysis of the observations using the Fe II lines shows <Bz> = -91 ± 35 G. The calculated false alarm probability values, 0.008 and 0.003, respectively, are above the value 10-3, indicating no detection.</p
VFISV: Very Fast Inversion of the Stokes Vector for the Helioseismic and Magnetic Imager
In this paper we describe in detail the implementation and main properties of
a new inversion code for the polarized radiative transfer equation (VFISV: Very
Fast inversion of the Stokes vector). VFISV will routinely analyze pipeline
data from the Helioseismic and Magnetic Imager (HMI) on-board of the Solar
Dynamics Observatory (SDO). It will provide full-disk maps (40964096
pixels) of the magnetic field vector on the Solar Photosphere every 10 minutes.
For this reason VFISV is optimized to achieve an inversion speed that will
allow it to invert 16 million pixels every 10 minutes with a modest number
(approx. 50) of CPUs. Here we focus on describing a number of important
details, simplifications and tweaks that have allowed us to significantly speed
up the inversion process. We also give details on tests performed with data
from the spectropolarimeter on-board of the Hinode spacecraft.Comment: 23 pages, 9 figures (2 color). Submitted for publication to Solar
Physic
Adiabatic following criterion, estimation of the nonadiabatic excitation fraction and quantum jumps
An accurate theory describing adiabatic following of the dark, nonabsorbing
state in the three-level system is developed. An analytical solution for the
wave function of the particle experiencing Raman excitation is found as an
expansion in terms of the time varying nonadiabatic perturbation parameter. The
solution can be presented as a sum of adiabatic and nonadiabatic parts. Both
are estimated quantitatively. It is shown that the limiting value to which the
amplitude of the nonadiabatic part tends is equal to the Fourier component of
the nonadiabatic perturbation parameter taken at the Rabi frequency of the
Raman excitation. The time scale of the variation of both parts is found. While
the adiabatic part of the solution varies slowly and follows the change of the
nonadiabatic perturbation parameter, the nonadiabatic part appears almost
instantly, revealing a jumpwise transition between the dark and bright states.
This jump happens when the nonadiabatic perturbation parameter takes its
maximum value.Comment: 33 pages, 8 figures, submitted to PRA on 28 Oct. 200
Wormholes and Ringholes in a Dark-Energy Universe
The effects that the present accelerating expansion of the universe has on
the size and shape of Lorentzian wormholes and ringholes are considered. It is
shown that, quite similarly to how it occurs for inflating wormholes, relative
to the initial embedding-space coordinate system, whereas the shape of the
considered holes is always preserved with time, their size is driven by the
expansion to increase by a factor which is proportional to the scale factor of
the universe. In the case that dark energy is phantom energy, which is not
excluded by present constraints on the dark-energy equation of state, that size
increase with time becomes quite more remarkable, and a rather speculative
scenario is here presented where the big rip can be circumvented by future
advanced civilizations by utilizing sufficiently grown up wormholes and
ringholes as time machines that shortcut the big-rip singularity.Comment: 11 pages, RevTex, to appear in Phys. Rev.
-Dimensional Lorentzian Wormholes in an Expanding Cosmological Background
We discuss -dimensional dynamical wormholes in an evolving
cosmological background with a throat expanding with time. These solutions are
examined in the general relativity framework. A linear relation between
diagonal elements of an anisotropic energy-momentum tensor is used to obtain
the solutions. The energy-momentum tensor elements approach the vacuum case
when we are far from the central object for one class of solutions. Finally, we
discuss the energy-momentum tensor which supports this geometry, taking into
account the energy conditions .Comment: 12 pages, 14 figures, references added, to appear in Astophysics and
Space Scienc
Realistic Equations of State for the Primeval Universe
Early universe equations of state including realistic interactions between
constituents are built up. Under certain reasonable assumptions, these
equations are able to generate an inflationary regime prior to the
nucleosynthesis period. The resulting accelerated expansion is intense enough
to solve the flatness and horizon problems. In the cases of curvature parameter
\kappa equal to 0 or +1, the model is able to avoid the initial singularity and
offers a natural explanation for why the universe is in expansion.Comment: 32 pages, 5 figures. Citations added in this version. Accepted EPJ
Lorentz breaking Effective Field Theory and observational tests
Analogue models of gravity have provided an experimentally realizable test
field for our ideas on quantum field theory in curved spacetimes but they have
also inspired the investigation of possible departures from exact Lorentz
invariance at microscopic scales. In this role they have joined, and sometime
anticipated, several quantum gravity models characterized by Lorentz breaking
phenomenology. A crucial difference between these speculations and other ones
associated to quantum gravity scenarios, is the possibility to carry out
observational and experimental tests which have nowadays led to a broad range
of constraints on departures from Lorentz invariance. We shall review here the
effective field theory approach to Lorentz breaking in the matter sector,
present the constraints provided by the available observations and finally
discuss the implications of the persisting uncertainty on the composition of
the ultra high energy cosmic rays for the constraints on the higher order,
analogue gravity inspired, Lorentz violations.Comment: 47 pages, 4 figures. Lecture Notes for the IX SIGRAV School on
"Analogue Gravity", Como (Italy), May 2011. V.3. Typo corrected, references
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