2,887 research outputs found

    Interaction between a normal shock wave and a turbulent boundary layer at high transonic speeds. Part 2: Wall shear stress

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    An analysis is presented of the flow in the two inner layers, the Reynolds stress sublayer and the wall layer. Included is the calculation of the shear stress at the wall in the interaction region. The limit processes considered are those used for an inviscid flow

    Interaction between a normal shock wave and a turbulent boundary layer at high transonic speeds. Part 1: Pressure distribution. Part 2: Wall shear stress. Part 3: Simplified formulas for the prediction of surface pressures and skin friction

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    An asymptotic description is derived for the interaction between a shock wave and a turbulent boundary layer in transonic flow, for a particular limiting case. The dimensionless difference between the external flow velocity and critical sound speed is taken to be much smaller than one, but large in comparison with the dimensionless friction velocity. The basic results are derived for a flat plate, and corrections for longitudinal wall curvature and for flow in a circular pipe are also shown. Solutions are given for the wall pressure distribution and the shape of the shock wave. Solutions for the wall shear stress are obtained, and a criterion for incipient separation is derived. Simplified solutions for both the wall pressure and skin friction distributions in the interaction region are given. These results are presented in a form suitable for use in computer programs

    Previously Unidentified Changes in Renal Cell Carcinoma Gene Expression Identified by Parametric Analysis of Microarray Data

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    BACKGROUND. Renal cell carcinoma is a common malignancy that often presents as a metastatic-disease for which there are no effective treatments. To gain insights into the mechanism of renal cell carcinogenesis, a number of genome-wide expression profiling studies have been performed. Surprisingly, there is very poor agreement among these studies as to which genes are differentially regulated. To better understand this lack of agreement we profiled renal cell tumor gene expression using genome-wide microarrays (45,000 probe sets) and compare our analysis to previous microarray studies. METHODS. We hybridized total RNA isolated from renal cell tumors and adjacent normal tissue to Affymetrix U133A and U133B arrays. We removed samples with technical defects and removed probesets that failed to exhibit sequence-specific hybridization in any of the samples. We detected differential gene expression in the resulting dataset with parametric methods and identified keywords that are overrepresented in the differentially expressed genes with the Fisher-exact test. RESULTS. We identify 1,234 genes that are more than three-fold changed in renal tumors by t-test, 800 of which have not been previously reported to be altered in renal cell tumors. Of the only 37 genes that have been identified as being differentially expressed in three or more of five previous microarray studies of renal tumor gene expression, our analysis finds 33 of these genes (89%). A key to the sensitivity and power of our analysis is filtering out defective samples and genes that are not reliably detected. CONCLUSIONS. The widespread use of sample-wise voting schemes for detecting differential expression that do not control for false positives likely account for the poor overlap among previous studies. Among the many genes we identified using parametric methods that were not previously reported as being differentially expressed in renal cell tumors are several oncogenes and tumor suppressor genes that likely play important roles in renal cell carcinogenesis. This highlights the need for rigorous statistical approaches in microarray studies.National Institutes of Healt

    A new strategy for finite element computations involving moving boundaries and interfaces-The deforming-spatial-domain/space-time procedure: II. Computation of free-surface flows, two-liquid flows, and flows with drifting cylinders

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    New finite element computational strategies for free-surface flows, two-liquid flows, and flows with drifting cylinders are presented. These strategies are based on the deforming spatial-domain/spacetime (DSD/ST) procedure. In the DSD/ST approach, the stabilized variational formulations for these types of flow problem are written over their space-time domains. One of the important features of the approach is that it enables one to circumvent the difficulty involved in remeshing every time step and thus reduces the projection errors introduced by such frequent remeshings. Computations are performed for various test problems mainly for the purpose of demonstrating the computational capability developed for this class of problems. In some of the test cases, such as the liquid drop problem, surface tension is taken into account. For flows involving drifting cylinders, the mesh moving and remeshing schemes proposed are convenient and reduce the frequency of remeshing

    Anatomy of the Soft-Photon Approximation in Hadron-Hadron Bremsstrahlung

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    A modified Low procedure for constructing soft-photon amplitudes has been used to derive two general soft-photon amplitudes, a two-s-two-t special amplitude MμTsTtsM^{TsTts}_{\mu} and a two-u-two-t special amplitude MμTuTtsM^{TuTts}_{\mu}, where s, t and u are the Mandelstam variables. MμTsTtsM^{TsTts}_{\mu} depends only on the elastic T-matrix evaluated at four sets of (s,t) fixed by the requirement that the amplitude be free of derivatives (∂\partialT/∂\partials and /or ∂\partialT/∂t\partial t). Likewise MμTuTtsM^{TuTts}_{\mu} depends only on the elastic T-matrix evaluated at four sets of (u,t). In deriving these amplitudes, we impose the condition that MμTsTtsM^{TsTts}_{\mu} and MμTuTtsM^{TuTts}_{\mu} reduce to MˉμTsTts\bar{M}^{TsTts}_{\mu} and MˉμTuTts\bar{M}^{TuTts}_{\mu}, respectively, their tree level approximations. The amplitude MˉμTsTts\bar{M}^{TsTts}_{\mu} represents photon emission from a sum of one-particle t-channel exchange diagrams and one-particle s-channel exchange diagrams, while the amplitude MˉμTuTts\bar{M}^{TuTts} _{\mu} represents photon emission from a sum of one-particle t-channel exchange diagrams and one-particle u-channel exchange diagrams. The precise expressions for MˉμTsTts\bar{M}^{TsTts}_{\mu} and MˉμTuTts\bar{M}^{TuTts}_{\mu} are determined by using the radiation decomposition identities of Brodsky and Brown. We point out that it is theoretically impossible to describe all bremsstrahlung processes by using only a single class of soft-photon amplitudes. At least two different classes are required: the amplitudes which depend on s and t or the amplitudes which depend on u and t. When resonance effects are important, the amplitude MμTsTtsM^{TsTts}_{\mu}, not MμLow(st)M^{Low(st)}_{\mu}, should be used. For processes with strong u-channel exchange effects, the amplitude MμTuTtsM^{TuTts}_{\mu} should be the first choice.Comment: 49 pages report # LA-UR-92-270

    Unsteady flow in a supercritical supersonic diffuser

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77051/1/AIAA-10045-786.pd

    Average Cross-Sectional Area of DebriSat Fragments Using Volumetrically Constructed 3D Representations

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    Debris fragments from the hypervelocity impact testing of DebriSat are being collected and characterized for use in updating existing satellite breakup models. One of the key parameters utilized in these models is the ballistic coefficient of the fragment which is directly related to its areatomass ratio. However, since the attitude of fragments varies during their orbital lifetime, it is customary to use the average crosssectional area in the calculation of the areatomass ratio. The average crosssectional area is defined as the average of the projected surface areas perpendicular to the direction of motion and has been shown to be equal to onefourth of the total surface area of a convex object. Unfortunately, numerous fragments obtained from the DebriSat experiment show significant concavity (i.e., shadowing) and thus we have explored alternate methods for computing the average crosssectional area of the fragments. An imaging system based on the volumetric reconstruction of a 3D object from multiple 2D photographs of the object was developed for use in determining the size characteristic (i.e., characteristics length) of the DebriSat fragments. For each fragment, the imaging system generates N number of images from varied azimuth and elevation angles and processes them using a spacecarving algorithm to construct a 3D point cloud of the fragment. This paper describes two approaches for calculating the average crosssectional area of debris fragments based on the 3D imager. Approach A utilizes the constructed 3D object to generate equally distributed crosssectional area projections and then averages them to determine the average crosssectional area. Approach B utilizes a weighted average of the area of the 2D photographs to directly compute the average crosssectional area. A comparison of the accuracy and computational needs of each approach is described as well as preliminary results of an analysis to determine the "optimal" number of images needed for the 3D imager to accurately measure the average cross sectional area of objects with known dimensions

    DebriSat - A Planned Laboratory-Based Satellite Impact Experiment for Breakup Fragment Characterization

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    DebriSat is a planned laboratory ]based satellite hypervelocity impact experiment. The goal of the project is to characterize the orbital debris that would be generated by a hypervelocity collision involving a modern satellite in low Earth orbit (LEO). The DebriSat project will update and expand upon the information obtained in the 1992 Satellite Orbital Debris Characterization Impact Test (SOCIT), which characterized the breakup of a 1960 's US Navy Transit satellite. There are three phases to this project: the design and fabrication of an engineering model representing a modern, 50-cm/50-kg class LEO satellite known as DebriSat; conduction of a laboratory-based hypervelocity impact to catastrophically break up the satellite; and characterization of the properties of breakup fragments down to 2 mm in size. The data obtained, including fragment size, area ]to ]mass ratio, density, shape, material composition, optical properties, and radar cross ]section distributions, will be used to supplement the DoD fs and NASA fs satellite breakup models to better describe the breakup outcome of a modern satellite. Updated breakup models will improve mission planning, environmental models, and event response. The DebriSat project is sponsored by the Air Force fs Space and Missile Systems Center and the NASA Orbital Debris Program Office. The design and fabrication of DebriSat is led by University of Florida with subject matter experts f support from The Aerospace Corporation. The major milestones of the project include the complete fabrication of DebriSat by September 2013, the hypervelocity impact of DebriSat at the Air Force fs Arnold Engineering Development Complex in early 2014, and fragment characterization and data analyses in late 2014
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