To the question of the intensification of the processes of uranium extraction from refractory raw materials

Recently, one of the main directions for increasing the extraction of uranium from difficult-to-hide ores is the use of intensifiers, which allow the most complete transfer of uranium from one valence state to another. In the article, the catalyst “M-1”, which is a compound of transition metals, is considered as an intensifier. Comparison of the kinetic dependencies of the sorption extraction of uranium by the ionites from the productive solutions of leaching of uranium-bearing ore in the presence of the “M-1” catalyst showed that they differ insignificantly. The possibility of sorption of uranium from productive solutions by natural sorbents in comparison with synthetic sorbents is investigated

Research on sorption properties of phosphoric production slag-waste

On the territory there are phosphorus-containing wastes - phosphorus slags, the basis of which is volostanite. The study of phosphorus slag as a uranium sorbent is of theoretical and practical interest. In the course of the research, comparable data were obtained on the sorption of the initial and activated slag by different reagents. The optimal conditions for the activation of phosphorus slag in order to increase its sorption properties have been determined

Revisiting the Kazakhstan natural sorbents modification

Kazakhstan ranks second in the world in natural uranium reserves and a leading position in its production. Hydrometallurgical processing of uranium raw materials results in a significant amount of liquid technogenic wastes containing radionuclides. Sorption cleaning methods for these wastes are the most effective ones. However, the high cost of synthetic sorbents and the low sorption capacity of natural ones is a deterrent to their use. So, to increase the sorption capacity of natural sorbents by their modification is an urgent problem. In this paper, a method to modify Kazakhstani natural zeolite was proposed by us and previously not investigated. Also the data of physicochemical studies of the initial raw material and the modified product was given and the increase in the natural sorbent specific surface in the modification process was demonstrated

Влияние дексаметазона и лидокаина на цитокиновый профиль и кровоточивость при эндоскопических риносинусохирургических вмешательствах

The objective: to evaluate the feasibility of using dexamethasone and lidocaine to potentiate the effect of anesthesia in patients with chronic polypous rhinosinusitis during functional endoscopic sinus surgery (FESS) interventions.Subjects and Methods. Clinical data, blood serum samples were collected prospectively from 52 patients who underwent FESS intervention. The patients were divided into 3 groups: Control Group ‒ C (n = 26), anti-inflammatory drugs were not administered; Dexamethasone Group ‒ D (n = 13), dexamethasone was administered (0.10‒0.15 mg/kg); and Lidocaine Group ‒ L (n = 13), a 1% solution of lidocaine was administered intravenously. The following parameters were studied: IL-6, IL-10, IL-18, alpha1-antitrypsin, and ferritin.Results. An increase of IL-6, IL-6/IL-10 was observed in Group C. An increase of IL-10 and a decrease of IL-6, IL-6/IL-10 were noted in Group D. In Group L, IL-6, IL-6/IL-10 did not change significantly. The intensity of bleeding was lower in Groups L (p < 0.001) and D (p < 0.05) versus Group C. Relative changes in the concentration of biomarkers within the normal range were detected in all groups.Conclusions. Changes in the cytokine profile are insignificant in patients with chronic polyposis rhinosinusitis during FESS performed under combined anesthesia.No convincing data on the need for intraoperative use of dexamethasone or intravenous lidocaine have been received.Цель: оценить целесообразность использования дексаметазона и лидокаина для потенцирования эффекта анестезии у больных хроническим полипозным риносинуситом при эндоскопических риносинусохирургических (ЭРСХ) вмешательствах.Материалы и методы. Клинические данные, образцы сыворотки крови были собраны проспективно у 52 больных, перенесших ЭРСХ-вмешательства. Сформировано три группы: контрольная (К, n = 26), в которой больным не вводили дексаметазон и лидокаин; группа Д (n =13), в которой использовали дексаметазон (0,10‒0,15 мг/кг), и группа Л (n = 13), где во время анестезии внутривенно вводили 1%-ный раствор лидокаина. Исследуемые показатели: ИЛ-6, ИЛ-10, ИЛ-18, альфа1-антитрипсин и ферритин.Результаты. Прирост ИЛ-6, ИЛ-6/ИЛ-10 наблюдался в группе К. В группе Д концентрация ИЛ-6 и соотношение ИЛ-6/ИЛ-10 снижались, а уровень ИЛ-10 нарастал. В группе Л ИЛ-6, ИЛ-6/ИЛ-10 значимо не изменились. Проявления кровоточивости в группах Л (p < 0,001) и Д (p < 0,05) были ниже, чем в группе К. Изменения концентрации других изученных биомаркеров не выходили за пределы нормы.Выводы. Изменения цитокинового профиля у больных с хроническим полипозным риносинуситом при ЭРСХ-вмешательствах, выполняемых в условиях сочетанной анестезии, являются незначительными. Убедительных данных о необходимости интраоперационного применения дексаметазона или внутривенного лидокаина не получено

Canalization of Gene Expression and Domain Shifts in the Drosophila Blastoderm by Dynamical Attractors

The variation in the expression patterns of the gap genes in the blastoderm of the fruit fly Drosophila melanogaster reduces over time as a result of cross regulation between these genes, a fact that we have demonstrated in an accompanying article in PLoS Biology (see Manu et al., doi:10.1371/journal.pbio.1000049). This biologically essential process is an example of the phenomenon known as canalization. It has been suggested that the developmental trajectory of a wild-type organism is inherently stable, and that canalization is a manifestation of this property. Although the role of gap genes in the canalization process was established by correctly predicting the response of the system to particular perturbations, the stability of the developmental trajectory remains to be investigated. For many years, it has been speculated that stability against perturbations during development can be described by dynamical systems having attracting sets that drive reductions of volume in phase space. In this paper, we show that both the reduction in variability of gap gene expression as well as shifts in the position of posterior gap gene domains are the result of the actions of attractors in the gap gene dynamical system. Two biologically distinct dynamical regions exist in the early embryo, separated by a bifurcation at 53% egg length. In the anterior region, reduction in variation occurs because of stability induced by point attractors, while in the posterior, the stability of the developmental trajectory arises from a one-dimensional attracting manifold. This manifold also controls a previously characterized anterior shift of posterior region gap domains. Our analysis shows that the complex phenomena of canalization and pattern formation in the Drosophila blastoderm can be understood in terms of the qualitative features of the dynamical system. The result confirms the idea that attractors are important for developmental stability and shows a richer variety of dynamical attractors in developmental systems than has been previously recognized

IMBALANCE OF IL -1β И IL -1RA CYTOKINES IN BLOOD SERUM AND BRONCHOALVEOLAR LAVAGE IN COPD PATIENTS

Abstract. The aim of present study was to determine levels of IL-1β and its inhibitor, IL-1ra in blood serum and bronchoalveolar lavage fluid (BALF) of 20 patients with COPD, depending on severity of their disease, activity of inflammatory process, bacterial and viral complication. Methods. Twenty male patients with COPD (stage 2 to 4) were examined. It was shown that all the patients with COPD displayed high levels of IL-1β, both in the area of inflammation, and in blood serum. The latter index was dependent on the severity of disease and activity of inflammatory process. In BALF, the contents of IL-1β in all the patients under study was significantly exceeded the normal levels of this cytokine even at the earliest stages of evolving COPD. concentration in serum was depended at stage of disease and activity of inflammatory procces. There were no differences in IL-1β concentrations in BALF of 2 - 4 stage COPD patients. IL-1ra levels in the patients’ serum were within normal levels, and tended to increase in BAL, thus causing imbalanced IL-1ra/IL-1β ratio both in the inflammatory area, as well as systemically. The maximal detection of respiratory pathogens did significantly correlate with decreased IL-1ra/ IL-1β ratio, thus confirming the data on infectious agents as a pathogenetic component in COPD

Optical properties of ZnSe, ZnCdSe and ZnSSe alloys doped with iron

Ionisation (2 + -to-3 + or 1 +) and intra-shell transitions of iron in bulk crystals of ZnS, ZnSe, CdSe and in their alloys are studied. The results of these studies allow us to verify the recent theoretical predictions on universal reference levels due to transition metal ions and to explain the nature of Fe-related nonradiative transitions ill ZnSe. We also demonstrate limitations of the Ludwig-Woodbury model for the description of intra-shell transitions of Fe2+. (C) 2000 Elsevier Science B.V. All rights reserved

Individual'nye kharakteristiki bol'nykh sakharnym diabetom kak faktory, vliyayushchie na dostizhenie i podderzhanie kompensatsii uglevodnogo obmena

Цель. Выявление наиболее значимых психосоциальных ?барьеров?, препятствующих реализации основной цели лечения СД. Материалы и методы. Для оценки степени компенсации СД определяли уровень HbA1c. Учитывали разнообразные психо-социальные характеристики, оценивали их по шкалам. В настоящем исследовании не установлено взаимосвязи между уровнем HbA1c и выраженностью субклинических тревожных и депрессивных расстройств, которые носят преимущественно нозогенный характер. Анализ полученых данных позволяет выдвинуть предположение, что в основе всех перечисленных факторов, оказывающих влияние на эффективность контроля СД, лежит базовая личностная предиспозиция, которая может быть названа склонностью к саморегуляции и означает способность субъекта произвольно изменять собственное поведение, организуя его в соответствии с данными, получаемыми в процессе оценки своего состояния, результатов собственных действий, сложившейся ситуации и др. Для лиц, склонных к саморегуляции, наиболее характерен самостоятельный ЛКБ, который проявляется в установке на собственное активное участие в лечении заболевания, включая постоянный самоконтроль за динамикой своего состояния. Выводы. В качестве основных предикторов, объясняющих 78% всех вариантов значений HbAlc, могут рассматриваться параметры темперамента и характера пациентов, оценка ими процесса обучения, позиция по отношению к терапии СД (локус контроля), а также возраст. Показатель подшкалы ОСХТК гармоничное второе Я?, ВАШ ?актуальность изучаемых вопросов?, доброжелательная атмосфера на занятиях?, факторные значения ?самостоятельного? ЛКБ и возраст больных обнаруживают отрицательную корелляционную связь с уровнем HbAlc, т.е. способствуют достижению компенсации СД. Показатели по подшкалам ОСХТК ?самозабвение?, ?импульсивность?, ?привязчивость?, BALL удовлетворение от обучения?, а также факторные значения врачебного? ЛКБ положительно кореллируют с уровнем HbA1c, т.е. затрудняют достижени компенсации СД

THE DIAGNOSTIC AND CLINICAL VALUE OF DETERMINATION OF α1-ANTITRYPSIN PHENOTYPE IN SYSTEMIC VASCULITIDES

α1-Antitrypsin (α1-AT) deficiency is a common genetic disorder characterized by low serum α1-AT levels and a clinical manifestation of pulmonary emphysema and liver disease. In addition to its classical manifestations, α1-AT deficiency frequently accompanies granulomatosis with polyangiitis (GPA); in this case the role of α1-AT deficiency in the clinical course of GPA has not been defined. Objective: to estimate the prevalence of pathological α1-AT phenotypes in GPA and other systemic vasculitides (SV) and to determinate their impact on the clinical course of GPA. Subjects and methods. The investigation enrolled 86 patients with SV, including GPA (n=47), microscopic polyangiitis (MPA) (n=16), eosinophilic granulomatosis with polyangiitis (EGPA) (n=12), and polyarteritis nodosa (PAN) (n=11). A control group included 46 healthy donors. Isoelectric focusing was used to phenotype α1-AT in blood samples and its concentrations were determined. The phenotypes of α1-AT were compared with the overall SV activity index using the Birmingham Vasculitis Activity Score (BVAS), the vasculitis damage index (VDI), the nature of an organ lesion, and the markers of immune inflammation (proteinase 3-antineutrophil cytoplasmic antibodies, total IgG, and C3 and C4 fractions of the complement system). Results and discussion. Pathological α1-AT phenotypes were detected in 17% (8/47) of the patients with GPA, 6.25% (1/16) of those with MPA and absent in EGPA and PAN. Patients with GPA had PiZZ (n=1), PiMZ (n=4), PiMF (n=2), and PiMS (n=1) phenotypes; those with MPA had a PiMS-phenotype. The detection of a pathological α1-AT phenotype in patients with GPA was characterized by the high values of BVAS and VDI (p<0.05) and the elevated levels of serum creatinine (p><0.01), anti-proteinase 3 antibodies, IgG, C3 and C4 fractions of the complement system (p><0.05). Conclusion. Pathological α1-AT phenotypes are more frequently detected in patients with GPA, which is accompanied by an enhanced immunological activity of the disease and high activity and damage indices. Key words: α1-antitrypsin; α1-antitrypsin deficiency; phenotyping; granulomatosis with polyangiitis; systemic vasculitis.><0.05) and the elevated levels of serum creatinine (p<0.01), anti-proteinase 3 antibodies, IgG, C3 and C4 fractions of the complement system (p<0.05). Conclusion. Pathological α1-AT phenotypes are more frequently detected in patients with GPA, which is accompanied by an enhanced immunological activity of the disease and high activity and damage indices