900 research outputs found
Effect of Multiple Higgs Fields on the Phase Structure of the SU(2)-Higgs Model
The SU(2)-Higgs model, with a single Higgs field in the fundamental
representation and a quartic self-interaction, has a Higgs region and a
confinement region which are analytically connected in the parameter space of
the theory; these regions thus represent a single phase. The effect of multiple
Higgs fields on this phase structure is examined via Monte Carlo lattice
simulations. For the case of N>=2 identical Higgs fields, there is no remaining
analytic connection between the Higgs and confinement regions, at least when
Lagrangian terms that directly couple different Higgs flavours are omitted. An
explanation of this result in terms of enhancement from overlapping phase
transitions is explored for N=2 by introducing an asymmetry in the hopping
parameters of the Higgs fields. It is found that an enhancement of the phase
transitions can still occur for a moderate (10%) asymmetry in the resulting
hopping parameters.Comment: 10 pages, 8 figures. References updated and minor typos correcte
The environment of x ray selected BL Lacs: Host galaxies and galaxy clustering
Using the Canada-France-Hawaii Telescope, we have imaged a complete, flux-limited sample of Einstein Medium Sensitivity Survey BL Lacertae objects in order to study the properties of BL Lac host galaxies and to use quantitative methods to determine the richness of their galaxy cluster environments
Activity in the human superior colliculus relating to endogenous saccade preparation and execution
In recent years a small number of studies have applied functional imaging techniques to investigate visual responses in the human superior colliculus (SC), but few have investigated its oculomotor functions. Here, in two experiments, we examined activity associated with endogenous saccade preparation. We used 3-T fMRI to record the hemodynamic activity in the SC while participants were either preparing or executing saccadic eye movements. Our results showed that not only executing a saccade (as previously shown) but also preparing a saccade produced an increase in the SC hemodynamic activity. The saccade-related activity was observed in the contralateral and to a lesser extent the ipsilateral SC. A second experiment further examined the contralateral mapping of saccade-related activity with a larger range of saccade amplitudes. Increased activity was again observed in both the contralateral and ipsilateral SC that was evident for large as well as small saccades. This suggests that the ipsilateral component of the increase in BOLD is not due simply to small-amplitude saccades producing bilateral activity in the foveal fixation zone. These studies provide the first evidence of presaccadic preparatory activity in the human SC and reveal that fMRI can detect activity consistent with that of buildup neurons found in the deeper layers of the SC in studies of nonhuman primates
Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase
Background Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty acids, and circulating metabolites remain incompletely characterized. Objectives This study sought to determine the molecular effects of statin therapy on multiple metabolic pathways. Methods Metabolic profiles based on serum nuclear magnetic resonance metabolomics were quantified at 2 time points in 4 population-based cohorts from the United Kingdom and Finland (N = 5,590; 2.5 to 23.0 years of follow-up). Concentration changes in 80 lipid and metabolite measures during follow-up were compared between 716 individuals who started statin therapy and 4,874 persistent nonusers. To further understand the pharmacological effects of statins, we used Mendelian randomization to assess associations of a genetic variant known to mimic inhibition of HMG-CoA reductase (the intended drug target) with the same lipids and metabolites for 27,914 individuals from 8 population-based cohorts. Results Starting statin therapy was associated with numerous lipoprotein and fatty acid changes, including substantial lowering of remnant cholesterol (80% relative to low-density lipoprotein cholesterol [LDL-C]), but only modest lowering of triglycerides (25% relative to LDL-C). Among fatty acids, omega-6 levels decreased the most (68% relative to LDL-C); other fatty acids were only modestly affected. No robust changes were observed for circulating amino acids, ketones, or glycolysis-related metabolites. The intricate metabolic changes associated with statin use closely matched the association pattern with rs12916 in the HMGCR gene (R2 = 0.94, slope 1.00 ± 0.03). Conclusions Statin use leads to extensive lipid changes beyond LDL-C and appears efficacious for lowering remnant cholesterol. Metabolomic profiling, however, suggested minimal effects on amino acids. The results exemplify how detailed metabolic characterization of genetic proxies for drug targets can inform indications, pleiotropic effects, and pharmacological mechanisms
Concave Plasmonic Particles: Broad-Band Geometrical Tunability in the Near Infra-Red
Optical resonances spanning the Near and Short Infra-Red spectral regime were
exhibited experimentally by arrays of plasmonic nano-particles with concave
cross-section. The concavity of the particle was shown to be the key ingredient
for enabling the broad band tunability of the resonance frequency, even for
particles with dimensional aspect ratios of order unity. The atypical
flexibility of setting the resonance wavelength is shown to stem from a unique
interplay of local geometry with surface charge distributions
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