Cross-sections of large-angle hadron production in proton-- and pion--nucleus interactions VIII: aluminium nuclei and beam momenta from {\pm}3 GeV/c to {\pm}15 GeV/c

We report on double-differential inclusive cross-sections of the production of secondary protons, charged pions, and deuterons, in the interactions with a 5% {\lambda}int thick stationary aluminium target, of proton and pion beams with momentum from \pm3 GeV/c to \pm15 GeV/c. Results are given for secondary particles with production angles between 20 and 125 degrees. Cross-sections on aluminium nuclei are compared with cross-sections on beryllium, carbon, copper, tin, tantalum and lead nuclei.Comment: 71 pages, 16 figures, 47 table

Cross-Sections of Large-Angle Hadron Production in Proton- and Pion-Nucleus Interactions III: Tantalum Nuclei and Beam Momenta from +/-3 Gev/c to +/-15 Gev/c

We report on double-differential inclusive cross-sections of the production of secondary protons, charged pions, and deuterons, in the interactions with a 5% nuclear interaction length thick stationary tantalum target, of proton and pion beams with momentum from +/-3 GeV/c to +/-15 GeV/c. Results are given for secondary particles with production angles between 20 and 125 degrees. They are of particular relevance for the optimization of the design parameters of the proton driver of a neutrino factory.Comment: 68 pages, 12 figures, corrections in v2: added 'HARP -CDP group' to author name, corrected two typos in Table 4 (last two p values for 65-90 degrees were all 0.972

Experience in implementing a program for basic life support and available automated defibrillation in a cancer center

Unified approaches to ensuring the chain of survival can improve the patient’s prognosis both in out-of-hospital and in-hospital cardiac arrest.Aim. To discuss practical issues of introducing a program for the availability of automated external defibrillation in a cancer center.Material and methods. For four years, our healthcare facility has been implementing a training program for basic and advanced life support according to the European Resuscitation Council standards, combined with the creation and development of an infrastructure for the availability of automatic defibrillation. A roadmap and infrastructure were developed for the project implementation.Results. In 2018-2022, 229 employees (114 doctors, 85 nurses and 30 nonmedical workers) were trained under the basic life support program. Fifteen defibrillators were placed in various units. During the specified period, first aid in case of sudden cardiac arrest using an automated external defibrillator before the resuscitation team arrival was independently provided by doctors and nurses of departments three times. To implement training in the continuous education system, the curriculum has passed the examination and accreditation in the edu. rosminzdrav system.Conclusion. The development and implementation of such initiatives requires significant organizational and methodological work, including continuous education system. However, in our opinion, this is an extremely useful tool for improving the safety and quality of medical care

PREDICTING THE RISK OF PROTHROMBOTIC CHANGES IN ADOLESCENTS WITH ESSENTIAL HYPERTENSION

Today, the problem of early diagnosis of hematological changes predisposing to the development of thrombotic complications in patients with essential hypertension (EH) is an urgent problem that requires close attention not only of physicians, but also of pediatricians. The aim of the study was the development of prognostic criteria for risk of prothrombotic changes (PC) in adolescents with EH, timely preventive measures and prevention of thrombotic complications. Sixty adolescents with EH without PC and 37 adolescents with EH and PC were examined. We used the following methods: clinical anamnestic (including genealogy), functional and ultrasound, laboratory, mathematical and statistical. To create a mathematical model of forecasting, discriminant analysis was used, with the help of which from the 59 proposed predictors the algorithm selected 8 most informative features: the C777T polymorphism of the 5,10-methylenetetrahydrofolate reductase gene, the A66G gene of the methionine synthase reductase gene, the daily diastolic blood pressure level, the level of the nocturnal systolic arterial pressure-time index of hypertension, systolic blood pressure during the day, weighed down by thrombotic genealogically history, early onset of thrombosis, burdened thrombotic genealogical history. Our method for predicting the risk of developing PC allows to place adolescents with EH having an increased risk of developing these coagulation shifts in a separate group, to identify thrombogenic risk in adolescence and, if necessary, to initiate preventive measures in time to reduce the incidence of thrombotic complications of EH and mortality of patients

Simcluster: clustering enumeration gene expression data on the simplex space

Transcript enumeration methods such as SAGE, MPSS, and sequencing-by-synthesis EST "digital northern", are important high-throughput techniques for digital gene expression measurement. As other counting or voting processes, these measurements constitute compositional data exhibiting properties particular to the simplex space where the summation of the components is constrained. These properties are not present on regular Euclidean spaces, on which hybridization-based microarray data is often modeled. Therefore, pattern recognition methods commonly used for microarray data analysis may be non-informative for the data generated by transcript enumeration techniques since they ignore certain fundamental properties of this space.

Here we present a software tool, Simcluster, designed to perform clustering analysis for data on the simplex space. We present Simcluster as a stand-alone command-line C package and as a user-friendly on-line tool. Both versions are available at: http://xerad.systemsbiology.net/simcluster.

Simcluster is designed in accordance with a well-established mathematical framework for compositional data analysis, which provides principled procedures for dealing with the simplex space, and is thus applicable in a number of contexts, including enumeration-based gene expression data

Burnout syndrome among doctors

This article presents a systematic review from 2009-2020 оn the topic of professional burnout among doctorsВ данной работе представлены результаты систематического обзора научных работ отечественных и зарубежных авторов, опубликованных в период с 2009-2020 гг. на тему профессионального выгорания среди враче

Search for active-sterile neutrino mixing using neutral-current interactions in NOvA

We report results from the first search for sterile neutrinos mixing with active neutrinos through a reduction in the rate of neutral-current interactions over a baseline of 810 km between the NOvA detectors. Analyzing a 14-kton detector equivalent exposure of 6.05 x 10(20) protons-on-target in the NuMI beam at Fermilab, we observe 95 neutral-current candidates at the Far Detector compared with 83.5 +/- 9.7(stat) +/- 9.4(syst) events predicted assuming mixing only occurs between active neutrino species. No evidence for upsilon(mu) -\u3e upsilon(mu) transitions is found. Interpreting these results within a 3 + 1 model, we place constraints on the mixing angles theta(24) \u3c 20.8 degrees and theta(34) \u3c 31.2 degrees at the 90% C.L. for 0.05 eV(2) \u3c= Delta m(41)(2) \u3c= 0.5 eV(2), the range of mass splittings that produce no significant oscillations over the Near Detector baseline

Measurement of the Neutrino Mixing Angle theta(23) in NOvA

This Letter reports new results on muon neutrino disappearance from NOvA, using a 14 kton detector equivalent exposure of 6.05 x 10(20) protons on target from the NuMI beam at the Fermi National Accelerator Laboratory. The measurement probes the muon-tau symmetry hypothesis that requires maximal theta(23) mixing (theta(23) = pi/4). Assuming the normal mass hierarchy, we find Delta m(32)(2) = (2.67 +/- 0.11) x 10(-3) eV(2) and sin(2) theta(23)at the two statistically degenerate values 0.404(-0.022)(+0.030) and 0.624(-0.030)(+0.022), both at the 68% confidence level. Our data disfavor the maximal mixing scenario with 2.6 sigma significance

Constraints on Oscillation Parameters from nu(e) Appearance and nu(mu) Disappearance in NOvA

Results are reported from an improved measurement of nu(mu) -\u3e nu(e) transitions by the NOvA experiment. Using an exposure equivalent to 6.05 x 10(20) protons on target, 33 nu(e) candidates are observed with a background of 8.2 +/- 0.8 (syst.). Combined with the latest NOvA nu(mu) disappearance data and external constraints from reactor experiments on sin(2) 2 theta(13), the hypothesis of inverted mass hierarchy with theta(23) in the lower octant is disfavored at greater than 93% C.L. for all values of delta(CP)

Влияние множественной лекарственной устойчивости возбудителя туберкулеза на исходы резекции легкого по поводу фиброзно-кавернозного туберкулеза

The objective: to study the impact of multiple drug resistant tuberculosis (MDR TB) on the outcomes of comprehensive treatment with surgical resection of fibrous cavernous pulmonary tuberculosis.Subjects and Methods. A prospective retrospective cohort study was performed; 526 HIV negative patients with unilateral fibrous cavernous tuberculosis who underwent lung resection were enrolled in the study. Patients were divided into two groups: multiple drug resistant tuberculosis - 216 subjects, drug susceptible tuberculosis - 310 subjects. Each group was divided into three subgroups: with the low (MDR TB - 105 subjects; DS TB 221 subjects), moderate (MDR TB - 67 subjects; DS TB - 68 subjects) and high activity (MDR TB - 44 subjects; DS TB - 21 subjects) of tuberculous inflammation.Results. The chances of adverse outcomes of comprehensive treatment with surgical resections of fibrous cavernous pulmonary tuberculosis are 2.5 times higher in MDR TB Group versus DS TB Group (p < 0.001; χ2, OR = 2.5; 95% CI 1.6-3.9). At the time of the surgery, among patients with MDR TB, there were significantly more patients with moderate and high activity of tuberculous inflammation versus DS TB Group (p < 0.001; χ2). When comparing the groups of patients with a homogeneous degree of tuberculous inflammation activity, no significant impact of MDR TB on the outcomes of comprehensive treatment with resections was found. However, the course of the postoperative period differed, in MDR TB Group, pleural cavity empyema (OR = 3.1; 95% CI 1.7-5.5) and tuberculosis exacerbations (OR = 4.7; 95% - CI 2.1-10.7) were significantly more frequent compared to DS TB Group.Цель исследования: изучить влияние туберкулеза с множественной лекарственной устойчивостью (МЛУ-ТБ) на исходы комплексного лечения с применением резекционных операций по поводу фиброзно-кавернозного туберкулеза (ФКТ) легких.Материалы и методы. Выполнено проспективно-ретроспективное когортное исследование, включено 526 ВИЧ-негативных пациентов с односторонним ФКТ, которым была выполнена резекция легких. Больные разделены на две группы: с МЛУ-ТБ – 216 пациентов, с ЛЧ-ТБ – 310 человек. Каждая группа разделена на три подгруппы: с низкой (МЛУ-ТБ 105; ЛЧ-ТБ 221 человек), средней (МЛУ-ТБ 67; ЛЧ-ТБ 68 пациентов) и высокой активностью (МЛУ-ТБ 44; ЛЧ-ТБ 21 человек) туберкулезного воспаления.Результаты исследования. Шансы на неблагоприятные исходы комплексного лечения с применением резекционных операций по поводу ФКТ в группе МЛУ-ТБ в 2,5 раза выше, чем в группе ЛЧ-ТБ (р < 0,001; χ2, ОШ = 2,5; 95%-ный ДИ 1,6-3,9). На момент проведения операции среди больных с МЛУ-ТБ значимо чаще были пациенты со средней и высокой активностью туберкулезного процесса по сравнению с группой ЛЧ-ТБ (р < 0,001; χ2). При сравнении однородных по степени активности туберкулезного воспаления групп пациентов не выявлено существенного влияния МЛУ-ТБ на исходы комплексного лечения с применением резекционных операций. Однако течение послеоперационного периода отличалось, в группе МЛУ-ТБ значимо чаще возникали эмпиемы плевральной полости (ОШ = 3,1; 95%-ный ДИ 1,7-5,5) и обострения туберкулеза (ОШ = 4,7; 95%-ный ДИ 2,1-10,7) в сравнении с группой ЛЧ-ТБ