Cancer detection in primary care: Insights from general practitioners

© 2015 Cancer Research UK. Background: General practitioners (GPs) have a key role in cancer detection as the usual first point of contact for patients with potential cancer symptoms. Nevertheless, there is limited work that investigates their perceptions of their role in the early detection of cancer. To address this gap, we aimed to gain an in-depth understanding of cancer diagnosis from the perspective of GPs. Methods: Individual face-to-face semi-structured interviews were conducted with 55 GPs from the North and North East of England and Greater London. All interviews were recorded and professionally transcribed verbatim. Repeated reading and co-coding engendered systematic thematic analysis across the interview material. Results: Three main themes emerged from the analysis of our data. First, we identified the burden of early cancer detection in general practice, both related to the anxiety and symptoms patients bring to GPs and the need for GPs to recognise patterns of cancer symptoms and refer appropriately; second, this burden is intensified by a perceived fragmentation of services within the National Health Service (NHS); and third, it is made more complex by the interface between general practice and public health. Conclusions: GPs occupy a challenging but pivotal role in cancer detection. It is crucial that this role be supported by policy and research

Using cultural probes to inform the design of assistive technologies

This paper discusses the practical implications of applying cultural probes to drive the design of assistive technologies. Specifically we describe a study in which a probe was deployed with home-based carers of people with dementia in order to capture critical data and gain insights of integrating the technologies into this sensitive and socially complex design space. To represent and utilise the insights gained from the cultural probes, we created narratives based on the probe data to enhance the design of assistive technologies.This work was supported by the Arts and Humanities Research Council (AH/K00266X/1) and RCUK through the Horizon Digital Economy Research grant (EP/G065802/1)

First-Order Provenance Games

We propose a new model of provenance, based on a game-theoretic approach to query evaluation. First, we study games G in their own right, and ask how to explain that a position x in G is won, lost, or drawn. The resulting notion of game provenance is closely related to winning strategies, and excludes from provenance all "bad moves", i.e., those which unnecessarily allow the opponent to improve the outcome of a play. In this way, the value of a position is determined by its game provenance. We then define provenance games by viewing the evaluation of a first-order query as a game between two players who argue whether a tuple is in the query answer. For RA+ queries, we show that game provenance is equivalent to the most general semiring of provenance polynomials N[X]. Variants of our game yield other known semirings. However, unlike semiring provenance, game provenance also provides a "built-in" way to handle negation and thus to answer why-not questions: In (provenance) games, the reason why x is not won, is the same as why x is lost or drawn (the latter is possible for games with draws). Since first-order provenance games are draw-free, they yield a new provenance model that combines how- and why-not provenance

DDF and Pohlmeyer invariants of (super)string

We show how the Pohlmeyer invariants of the bosonic string are expressible in terms of DDF invariants. Quantization of the DDF observables in the usual way yields a consistent quantization of the algebra of Pohlmeyer invariants. Furthermore it becomes straightforward to generalize the Pohlmeyer invariants to the superstring as well as to all backgrounds which allow a free field realization of the worldsheet theory.Comment: 17 pp, minor typos corrected, references to papers by Isaev and Borodulin added, which contain essentially the same results as reported her

Remarks on the Classical Size of D-Branes

We discuss different criteria for `classical size' of extremal Dirichlet p-branes in type-II supergravity. Using strong-weak coupling duality, we find that the size of the strong-coupling region at the core of the (p<3)-branes, is always given by the asymptotic string scale, if measured in the weakly coupled dual string metric. We also point out how the eleven-dimensional Planck scale arises in the classical 0-brane solution, as well as the ten-dimensional Planck scale in the D-instanton solution.Comment: 8 pp, harvma

Three-Nucleon Force and the Δ\Delta-Mechanism for Pion Production and Pion Absorption

The description of the three-nucleon system in terms of nucleon and $\Delta$ degrees of freedom is extended to allow for explicit pion production (absorption) from single dynamic $\Delta$ de-excitation (excitation) processes. This mechanism yields an energy dependent effective three-body hamiltonean. The Faddeev equations for the trinucleon bound state are solved with a force model that has already been tested in the two-nucleon system above pion-production threshold. The binding energy and other bound state properties are calculated. The contribution to the effective three-nucleon force arising from the pionic degrees of freedom is evaluated. The validity of previous coupled-channel calculations with explicit but stable $\Delta$ isobar components in the wavefunction is studied.Comment: 23 pages in Revtex 3.0, 9 figures (not included, available as postscript files upon request), CEBAF-TH-93-0

Perturbative dynamics of matrix string for the membrane

Recently Sekino and Yoneya proposed a way to regularize the world volume theory of membranes wrapped around $S^1$ by matrices and showed that one obtains matrix string theory as a regularization of such a theory. We show that this correspondence between matrix string theory and wrapped membranes can be obtained by using the usual M(atrix) theory techniques. Using this correspondence, we construct the super-Poincare generators of matrix string theory at the leading order in the perturbation theory. It is shown that these generators satisfy 10 dimensional super-Poincar\'e algebra without any anomaly.Comment: 23 pages, 1 figur

First Attempt at Spectroscopic Detection of Gravity Modes in a Long-Period Pulsating Subdwarf B Star -- PG 1627+017

In the first spectroscopic campaign for a PG 1716 variable (or long-period pulsating subdwarf B star), we succeeded in detecting velocity variations due to g-mode pulsations at a level of 1.0-1.5 km/s.The observations were obtained during 40 nights on 2-m class telescopes in Arizona, South Africa,and Australia. The target,PG1627+017, is one of the brightest and largest amplitude stars in its class.It is also the visible component of a post-common envelope binary.Our final radial velocity data set includes 84 hours of time-series spectroscopy over a time baseline of 53 days. Our derived radial velocity amplitude spectrum, after subtracting the orbital motion, shows three potential pulsational modes 3-4 sigma above the mean noise level, at 7201.0s,7014.6s and 7037.3s.Only one of the features is statistically likely to be real,but all three are tantalizingly close to, or a one day alias of, the three strongest periodicities found in the concurrent photometric campaign. We further attempted to detect pulsational variations in the Balmer line amplitudes. The single detected periodicity of 7209 s, although weak, is consistent with theoretical expectations as a function of wavelength.Furthermore, it allows us to rule out a degree index of l= 3 or l= 5 for that mode. Given the extreme weakness of g-mode pulsations in these stars,we conclude that anything beyond simply detecting their presence will require larger telescopes,higher efficiency spectral monitoring over longer time baselines,improved longitude coverage, and increased radial velocity precision.Comment: 39 pages, 9 figures, 4 tables, ApJ accepted. See postscript for full abtrac

Electromagnetic transitions of the helium atom in superstrong magnetic fields

We investigate the electromagnetic transition probabilities for the helium atom embedded in a superstrong magnetic field taking into account the finite nuclear mass. We address the regime \gamma=100-10000 a.u. studying several excited states for each symmetry, i.e. for the magnetic quantum numbers 0,-1,-2,-3, positive and negative z parity and singlet and triplet symmetry. The oscillator strengths as a function of the magnetic field, and in particular the influence of the finite nuclear mass on the oscillator strengths are shown and analyzed.Comment: 10 pages, 8 figure

Ricci Collineations of the Bianchi Type II, VIII, and IX Space-times

Ricci and contracted Ricci collineations of the Bianchi type II, VIII, and IX space-times, associated with the vector fields of the form (i) one component of $\xi^a(x^b)$ is different from zero and (ii) two components of $\xi^a(x^b)$ are different from zero, for $a,b=1,2,3,4$, are presented. In subcase (i.b), which is $\xi^a= (0,\xi^2(x^a),0,0)$, some known solutions are found, and in subcase (i.d), which is $\xi^a =(0,0,0,\xi^4(x^a))$, choosing $S(t)=const.\times R(t)$, the Bianchi type II, VIII, and IX space-times is reduced to the Robertson-Walker metric.Comment: 12 Pages, LaTeX, 1 Table, no figure