Frequency-Dependent Template Profiles for High Precision Pulsar Timing

Pulsar timing experiments require high fidelity template profiles in order to minimize the biases in pulse time-of-arrival (TOA) measurements and their uncertainties. Efforts to acquire more precise TOAs given fixed effective area of telescopes, finite receiver noise, and limited integration time have led pulsar astronomers to the solution of implementing ultra-wideband receivers. This solution, however, has run up against the problem that pulse profile shapes evolve with frequency, which raises the question of how to properly measure and analyze TOAs obtained using template-matching methods. This paper proposes a new method for one facet of this problem, that of template profile generation, and demonstrates it on the well-timed millisecond pulsar J1713+0747. Specifically, we decompose pulse profile evolution into a linear combination of basis eigenvectors, the coefficients of which change slowly with frequency such that their evolution is modeled simply by a sum of low degree piecewise polynomial spline functions. These noise-free, high fidelity, frequency-dependent templates can be used to make measurements of so-called "wideband TOAs" simultaneously with an estimate of the instantaneous dispersion measure. The use of wideband TOAs is becoming important for pulsar timing array experiments, as the volume of datasets comprised of conventional, subbanded TOAs are quickly becoming unwieldly for the Bayesian analyses needed to uncover latent gravitational wave signals. Although motivated by high precision timing experiments, our technique is applicable in more general pulsar observations.Comment: 16 pages, 6 figures, accepted to Ap

A broadband radio study of the average profile and giant pulses from PSR B1821-24A

We present the results of wide-band (720-2400 MHz) study of PSR B1821-24A (J1824-2452A, M28A), an energetic millisecond pulsar visible in radio, X-rays and gamma-rays. In radio, the pulsar has a complex average profile which spans >85% of the spin period and exhibits strong evolution with observing frequency. For the first time we measure phase-resolved polarization properties and spectral indices of radio emission throughout almost all of the on-pulse window. We combine this knowledge with the high-energy information to compare M28A to other known gamma-ray millisecond pulsars and to speculate that M28A's radio emission originates in multiple regions within its magnetosphere (i.e. both in the slot or outer gaps near the light cylinder and at lower altitudes above the polar cap). M28A is one of the handful of pulsars which are known to emit Giant Pulses (GPs) -- short, bright radio pulses of unknown nature. We report a drop in the linear polarization of the average profile in both windows of GP generation and also a `W'-shaped absorption feature (resembling a double notch), partly overlapping with one of the GP windows. The GPs themselves have broadband spectra consisting of multiple patches with fractional spectral width ($\Delta\nu/\nu$) of about 0.07. Although our time resolution was not sufficient to resolve the GP structure on the microsecond scale, we argue that GPs from this pulsar most closely resemble the GPs from the main pulse of the Crab pulsar, which consist of a series of narrowband nanoshots.Comment: 16 pages, 8 figures, accepted to Ap

Simultaneous Multi-band Radio & X-ray Observations of the Galactic Center Magnetar SGR 1745−-2900

We report on multi-frequency, wideband radio observations of the Galactic Center magnetar (SGR 1745$-$2900) with the Green Bank Telescope for $\sim$100 days immediately following its initial X-ray outburst in April 2013. We made multiple simultaneous observations at 1.5, 2.0, and 8.9 GHz, allowing us to examine the magnetar's flux evolution, radio spectrum, and interstellar medium parameters (such as the dispersion measure (DM), the scattering timescale and its index). During two epochs, we have simultaneous observations from the Chandra X-ray Observatory, which permitted the absolute alignment of the radio and X-ray profiles. As with the two other radio magnetars with published alignments, the radio profile lies within the broad peak of the X-ray profile, preceding the X-ray profile maximum by $\sim$0.2 rotations. We also find that the radio spectral index $\gamma$ is significantly negative between $\sim$2 and 9 GHz; during the final $\sim$30 days of our observations $\gamma \sim -1.4$, which is typical of canonical pulsars. The radio flux has not decreased during this outburst, whereas the long-term trends in the other radio magnetars show concomitant fading of the radio and X-ray fluxes. Finally, our wideband measurements of the DMs taken in adjacent frequency bands in tandem are stochastically inconsistent with one another. Based on recent theoretical predictions, we consider the possibility that the dispersion measure is frequency-dependent. Despite having several properties in common with the other radio magnetars, such as $L_{\textrm{X,qui}}/L_{\textrm{rot}} \lesssim 1$, an increase in the radio flux during the X-ray flux decay has not been observed thus far in other systems.Comment: 15 pages, 9 figures, 3 tables; accepted to Ap

Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq

Genome editing has shown great promise for clinical translation but also revealed the risk of genotoxicity caused by off-target effects of programmable nucleases. Here we describe chromosomal aberrations analysis by single targeted linker-mediated PCR sequencing (CAST-Seq), a preclinical assay to identify and quantify chromosomal aberrations derived from on-target and off-target activities of CRISPR-Cas nucleases or transcriptional activator-like effector nucleases (TALENs), respectively, in human hematopoietic stem cells (HSCs). Depending on the employed designer nuclease, CAST-Seq detected translocations in 0%–0.5% of gene-edited human CD34+ HSCs, and up to 20% of on-target loci harbored gross rearrangements. Moreover, CAST-Seq detected distinct types of chromosomal aberrations, such as homology-mediated translocations, that are mediated by homologous recombination and not off-target activity. CAST-Seq is a sensitive assay able to identify and quantify unintended chromosomal rearrangements in addition to the more typical mutations at off-target sites. CAST-Seq analyses may be particularly relevant for therapeutic genome editing to enable thorough risk assessment before clinical application of gene-edited products

The nanograv nine-year data set: Excess noise in millisecond pulsar arrival times

Gravitational wave (GW) astronomy using a pulsar timing array requires high-quality millisecond pulsars (MSPs), correctable interstellar propagation delays, and high-precision measurements of pulse times of arrival. Here we identify noise in timing residuals that exceeds that predicted for arrival time estimation for MSPs observed by the North American Nanohertz Observatory for Gravitational Waves. We characterize the excess noise using variance and structure function analyses. We find that 26 out of 37 pulsars show inconsistencies with a white-noise-only model based on the short timescale analysis of each pulsar, and we demonstrate that the excess noise has a red power spectrum for 15 pulsars. We also decompose the excess noise into chromatic (radio-frequency-dependent) and achromatic components. Associating the achromatic red-noise component with spin noise and including additional power-spectrum-based estimates from the literature, we estimate a scaling law in terms of spin parameters (frequency and frequency derivative) and data-span length and compare it to the scaling law of Shannon & Cordes. We briefly discuss our results in terms of detection of GWs at nanohertz frequencies