1,598 research outputs found
Transfer of K-types on local theta lifts of characters and unitary lowest weight modules
In this paper we study representations of the indefinite orthogonal group
O(n,m) which are local theta lifts of one dimensional characters or unitary
lowest weight modules of the double covers of the symplectic groups. We apply
the transfer of K-types on these representations of O(n,m), and we study their
effects on the dual pair correspondences. These results provide examples that
the theta lifting is compatible with the transfer of K-types. Finally we will
use these results to study subquotients of some cohomologically induced
modules
Nonnegatively curved homogeneous metrics obtained by scaling fibers of submersions
We consider invariant Riemannian metrics on compact homogeneous spaces G/H
where an intermediate subgroup K between G and H exists, so that the
homogeneous space G/H is the total space of a Riemannian submersion. We study
the question as to whether enlarging the fibers of the submersion by a constant
scaling factor retains the nonnegative curvature in the case that the
deformation starts at a normal homogeneous metric. We classify triples of
groups (H,K,G) where nonnegative curvature is maintained for small
deformations, using a criterion proved by Schwachh\"ofer and Tapp. We obtain a
complete classification in case the subgroup H has full rank and an almost
complete classification in the case of regular subgroups.Comment: 23 pages; minor revisions, to appear in Geometriae Dedicat
The trace of the heat kernel on a compact hyperbolic 3-orbifold
The heat coefficients related to the Laplace-Beltrami operator defined on the
hyperbolic compact manifold H^3/\Ga are evaluated in the case in which the
discrete group \Ga contains elliptic and hyperbolic elements. It is shown
that while hyperbolic elements give only exponentially vanishing corrections to
the trace of the heat kernel, elliptic elements modify all coefficients of the
asymptotic expansion, but the Weyl term, which remains unchanged. Some physical
consequences are briefly discussed in the examples.Comment: 11 page
White noise analysis on manifolds and the energy representation of a gauge group
The energy representation of a gauge group on a Riemannian manifold has been
discussed by several authors. Y. Shimada has shown the irreducibility for
compact Riemannian manifold, using white noise analysis. In this paper we
extend its technique to noncompact Riemannian manifolds which have differential
operators satisfying some conditions.Comment: 9 page
Transparency of Regulatory Data across the European Medicines Agency, Health Canada, and US Food and Drug Administration
Based on an analysis of relevant laws and policies, regulator data portals, and information requests, we find that clinical data, including clinical study reports, submitted to the European Medicines Agency and Health Canada to support approval of medicines are routinely made publicly available
System of Complex Brownian Motions Associated with the O'Connell Process
The O'Connell process is a softened version (a geometric lifting with a
parameter ) of the noncolliding Brownian motion such that neighboring
particles can change the order of positions in one dimension within the
characteristic length . This process is not determinantal. Under a special
entrance law, however, Borodin and Corwin gave a Fredholm determinant
expression for the expectation of an observable, which is a softening of an
indicator of a particle position. We rewrite their integral kernel to a form
similar to the correlation kernels of determinantal processes and show, if the
number of particles is , the rank of the matrix of the Fredholm determinant
is . Then we give a representation for the quantity by using an -particle
system of complex Brownian motions (CBMs). The complex function, which gives
the determinantal expression to the weight of CBM paths, is not entire, but in
the combinatorial limit it becomes an entire function providing
conformal martingales and the CBM representation for the noncolliding Brownian
motion is recovered.Comment: v3: AMS_LaTeX, 25 pages, no figure, minor corrections made for
publication in J. Stat. Phy
Dirac cohomology, elliptic representations and endoscopy
The first part (Sections 1-6) of this paper is a survey of some of the recent
developments in the theory of Dirac cohomology, especially the relationship of
Dirac cohomology with (g,K)-cohomology and nilpotent Lie algebra cohomology;
the second part (Sections 7-12) is devoted to understanding the unitary
elliptic representations and endoscopic transfer by using the techniques in
Dirac cohomology. A few problems and conjectures are proposed for further
investigations.Comment: This paper will appear in `Representations of Reductive Groups, in
Honor of 60th Birthday of David Vogan', edited by M. Nervins and P. Trapa,
published by Springe
Robot rights? Towards a social-relational justification of moral consideration \ud
Should we grant rights to artificially intelligent robots? Most current and near-future robots do not meet the hard criteria set by deontological and utilitarian theory. Virtue ethics can avoid this problem with its indirect approach. However, both direct and indirect arguments for moral consideration rest on ontological features of entities, an approach which incurs several problems. In response to these difficulties, this paper taps into a different conceptual resource in order to be able to grant some degree of moral consideration to some intelligent social robots: it sketches a novel argument for moral consideration based on social relations. It is shown that to further develop this argument we need to revise our existing ontological and social-political frameworks. It is suggested that we need a social ecology, which may be developed by engaging with Western ecology and Eastern worldviews. Although this relational turn raises many difficult issues and requires more work, this paper provides a rough outline of an alternative approach to moral consideration that can assist us in shaping our relations to intelligent robots and, by extension, to all artificial and biological entities that appear to us as more than instruments for our human purpose
Statistical Mechanics of Membrane Protein Conformation: A Homopolymer Model
The conformation and the phase diagram of a membrane protein are investigated
via grand canonical ensemble approach using a homopolymer model. We discuss the
nature and pathway of -helix integration into the membrane that results
depending upon membrane permeability and polymer adsorptivity. For a membrane
with the permeability larger than a critical value, the integration becomes the
second order transition that occurs at the same temperature as that of the
adsorption transition. For a nonadsorbing membrane, the integration is of the
first order due to the aggregation of -helices.Comment: RevTeX with 5 postscript figure
HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology
The epidemic increase of non-alcoholic fatty liver diseases (NAFLD) requires a deeper understanding of the regulatory circuits controlling the response of liver metabolism to nutritional challenges, medical drugs, and genetic enzyme variants. As in vivo studies of human liver metabolism are encumbered with serious ethical and technical issues, we developed a comprehensive biochemistry-based kinetic model of the central liver metabolism including the regulation of enzyme activities by their reactants, allosteric effectors, and hormone-dependent phosphorylation. The utility of the model for basic research and applications in medicine and pharmacology is illustrated by simulating diurnal variations of the metabolic state of the liver at various perturbations caused by nutritional challenges (alcohol), drugs (valproate), and inherited enzyme disorders (galactosemia). Using proteomics data to scale maximal enzyme activities, the model is used to highlight differences in the metabolic functions of normal hepatocytes and malignant liver cells (adenoma and hepatocellular carcinoma)
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