COVID-19-associated coagulopathy in children and adolescents

The pandemic of the new coronavirus infection COVID-19 in 2020 has become the main health problem across the globe. A special characteristic of the SARSCoV-2 virus is tropism to the vascular endothelium with the  development of endotheliitis, which entails a number of typical disorders of the blood coagulation system: coagulopathy with increased thrombin generation, D-dimer, decreased fibrinolysis and prolonged prothrombin time. The coagulation disorder in COVID-19 is called thromboinflammation. Hyperinflammation, increased blood levels of von Willebrand factor, coagulation factor VIII, neutrophil extracellular traps, platelet activation, microvesicles play a significant role in the pathogenesis of hypercoagulation in COVID-19. To date, it is known that cases of COVID-19 in children and adolescents constitute a small part of the total number of patients with diagnosed COVID-19, and disorders of the blood coagulation system are similar to those in adults. The degree of hypercoagulable syndrome and the risk of thrombosis depend on the severity of COVID-19. And for children they are most expressed with the development of a hyperinflammatory immune response, called multisystem inflammatory syndrome. At the same time, clinical studies of the pathogenesis of COVID-19 in adults and children and the search for optimal methods of therapy for thrombus inflammation, which underlies the pathogenesis of COVID-19, continue

Changing of mineral status in organism of young athletes within one-year training cycle

Vytauto Didžiojo universitetasŠvietimo akademij

COMPLICATIONS AND OUTCOMES OF PREGNANCY IN CHRONIC KIDNEY DISEASE

Pregnancy in women with kidney disorders, even with preserved renal function, is associated with higher than in the population rates of obstetric and perinatal complications, such as eclampsia, preterm delivery, surgical deliveries and intensive care for newborns.This article presents our own data on complications and outcomes of pregnancies in 156 women with various stages of chronic kidney disease (CKD). From these, 87 patients had CKD stage I, 29 with CKD stage II and 40 with CKD stages III, IV, V. For the first time in Russia, the authors summarize their unique experience in management of pregnancy with CKD, underline a high probability (27,5%) of its primary detection during pregnancy, discuss the algorithms of assessment, prevention and treatment of various gestational complications in CKD (pre-eclampsia, urinary tract infections, feto-placental insufficiency, anemia, acute renal damage), as well as the influence of pregnancy on renal function at long-term post-delivery. A direct correlation between the CKD stage, frequency of pre-eclampsia, feto-placental insufficiency, preterm deliveries, surgical deliveries by caesarean section and babies’ status at birth is demonstrated.Based on their ample clinical material, they confirmprobability of favorable pregnancy outcomes in CKD patients with stable renal function without severe arterial hypertension during pregnancy: for a baby in 87%, for the mother in 90% (maintenance of the same CKD stage). The risk of persistent deterioration of renal function during pregnancy and puerperium in women with CKD is higher in CKD stage IV, as well as in the case of early development of pre-eclampsia; it also correlates with severity of the latter.The probability of a favorable obstetric and nephrological outcome is higher when the pregnancy is planned and intensively co-managed by an obstetrician/gynaecologist and a nephrologist from early weeks of gestation onwards

Reversible Water-Induced Structural and Magnetic Transformations and Selective Water Adsorption Properties of Poly(manganese 1,1′-ferrocenediyl-bis(H-phosphinate))

© 2016 American Chemical Society.A flexible and hydrolytically stable metal-organic framework [Mn(H2O)2(Fc(PHOO)2)·2H2O]n has been synthesized using ferrocene-based ligand bearing phosphinic groups (Fc(PHOOH)2 = 1,1′-ferrocenediyl-bis(H-phosphinic acid)). In this compound manganese atoms are bound by phosphinate fragments to give infinite chains, and the latter are interconnected by ferrocene groups to form two-dimensional coordination polymer. The elimination of both coordinated and lattice water molecules during heating up to 150 °C produced the compound, which is nonporous for nitrogen, but can selectively adsorb water over methanol and other solvents at 298 K. The reversible structural transformation during adsorption/desorption of water is also reflected in a change of magnetic properties of the metal-organic framework

Crystal size versus paddle wheel deformability: selective gated adsorption transitions of the switchable metal-organic frameworks DUT-8(Co) and DUT-8(Ni)

Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.Switchable pillared layer metal-organic frameworks M2(2,6-ndc)2(dabco) (DUT-8(M), M = Ni, Co, 2,6-ndc = 2,6-naphthalenedicarboxylate, dabco = 1,4-diazabicyclo-[2.2.2]-octane, DUT – Dresden University of Technology) were synthesised in two different crystallite size regimes to produce particles up to 300 μm and smaller particles around 0.1 μm, respectively. The textural properties and adsorption-induced switchability of the materials, obtained from both syntheses, were studied by physisorption of N2 at 77 K, CO2 at 195 K and n-butane at 273 K, revealing pronounced differences in adsorption behavior for Ni and Co analogues. While the smaller nano-sized particles (50-200 nm) are rigid and show no gating transitions confirming the importance of crystallite size, the large particles show pronounced switchability with characteristic differences for the two metals resulting in distinct recognition effects for various gases and vapours. Adsorption of various vapours demonstrates consistently a higher energetic barrier for the “gate opening” of DUT-8(Co) in contrast to DUT-8(Ni), as the “gate opening” pressure for Co based materials is shifted to a higher value for adsorption of dichloromethane at 298 K. Evaluation of crystallographic data, obtained from single crystal and powder X-ray diffraction analysis, showed distinct geometric differences in the paddle-wheel units of the respective MOFs. These differences are further disclosed by solid-state UV-vis, FT-IR and Raman spectroscopy. Magnetic properties of DUT-8(Co) and DUT-8(Ni) were investigated, indicating a high-spin state for both materials at room temperature. Density functional theory (DFT) simulations confirmed a distinct energetic differences for Ni and Co analogues with a higher energetic penalty for the structural gate-opening transformation for DUT-8(Co) compared to DUT-8(Ni,) explaining the different flexibility behaviour of these isomorphous MOFs

Reversible Water-Induced Structural and Magnetic Transformations and Selective Water Adsorption Properties of Poly(manganese 1,1′-ferrocenediyl-bis(H-phosphinate))

© 2016 American Chemical Society.A flexible and hydrolytically stable metal-organic framework [Mn(H2O)2(Fc(PHOO)2)·2H2O]n has been synthesized using ferrocene-based ligand bearing phosphinic groups (Fc(PHOOH)2 = 1,1′-ferrocenediyl-bis(H-phosphinic acid)). In this compound manganese atoms are bound by phosphinate fragments to give infinite chains, and the latter are interconnected by ferrocene groups to form two-dimensional coordination polymer. The elimination of both coordinated and lattice water molecules during heating up to 150 °C produced the compound, which is nonporous for nitrogen, but can selectively adsorb water over methanol and other solvents at 298 K. The reversible structural transformation during adsorption/desorption of water is also reflected in a change of magnetic properties of the metal-organic framework