Hygienic substantiation of calculating models for predicting toxicity of different classes insecticides (first part).

This work is the first part of our study to develop alternative experimental mathematic models for predicting toxicity of insecticides. In the first stage, calculations will be carried out and the most reliable models will be proposed. In the second – a statistical analysis and comparative estimation of the toxicometric parameters obtained experimentally and calculated according to the proposed equations. The purpose of the research is the scientific substantiation of the calculation models for predicting toxicity of insecticides of different classes. Data on the physico-chemical properties and toxicometry parameters of fungicides are taken from the PPDB pesticides database. Insecticides of such chemical classes as derivatives of tetram and tetronic acids, benzoylureas, carbamates, neonicotinoids, pyrethroids, organophosphorus compounds, avermectins were selected for analysis. It has been established that there is a significant positive correlation between NO(A)EL in the chronic experiment of all insecticides, the median lethal doses at oral administration (LD50 per os) of pyrithoids and neonicotinoids, and the molecular weight (at p<0.05). There is a significant negative correlation between the toxicometry parameters of all insecticides and their individual groups (pyrithoids, neonicotinoids, organophosphorus compounds) and melting temperature and the octanol-water partition coefficient, log Po/w (at p<0.05). It is proved that the proposed calculation models for predicting insecticide hazards are adequate according to Fisher's criterion, and the coefficients of regression equations are reliable according to Student's criterion (p<0,05)

Comparative hygienic risk assessment of groundwater contamination by herbicides of different chemical classes and hazard prediction for human after consumption of contaminated water = Порівняльна гігієнічна оцінка ризику забруднення підземних вод гербіцидами різних класів та прогноз небезпеки для людини при споживанні забрудненої води.

Antonenko A. M., Vavrinevych O. P., Omelchuk S. T., Korshun M. M. Comparative hygienic risk assessment of groundwater contamination by herbicides of different chemical classes and hazard prediction for human after consumption of contaminated water  = Порівняльна гігієнічна оцінка ризику забруднення підземних вод гербіцидами різних класів та прогноз небезпеки для людини при споживанні забрудненої води. Journal of Education, Health and Sport. 2016;6(9):873-882. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.161844http://ojs.ukw.edu.pl/index.php/johs/article/view/3942   The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7                                                                                                                                     © The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 02.09.2016. Revised 24.09.2016. Accepted: 30.09.2016.   УДК 613:632.954:633.15 COMPARATIVE HYGIENIC RISK ASSESSMENT OF GROUNDWATER CONTAMINATION BY HERBICIDES OF DIFFERENT CHEMICAL CLASSES AND HAZARD PREDICTION FOR HUMAN AFTER CONSUMPTION OF CONTAMINATED WATER  A. M. Antonenko,  O. P. Vavrinevych, S. T. Omelchuk, M. M. Korshun O.O. Bogomolets National medical universityDepartment of hygiene and ecology Abstract In the structure of main groundwater pollutants leading position is occupied by chemical pesticides. Herbicides are among the most widely used classes of pesticides, according to application technology introduced directly into the soil. Migrating on the soil profile, they create a danger of groundwater contamination that requires their constant control and monitoring. Objective – comparative evaluation of risk of adverse effects on human health by drinking of water contaminated with the most common herbicides. We have studied representatives of herbicides extensively used in agriculture: chloroacetamides; sulfonil-carbonyl-triazolinone, oxazoles, triketones, sulfonylurea, phosphonoglycine. Prediction of migration opportunities in groundwater of studied herbicides was carried out by GUS – Groundwater Ubiquity Score. For determination of potential risk to human health by drinking of water containing pesticides screening model of maximum concentration of pesticide in groundwater determination (SCI-GROW) was used. For the evaluation of the parameters of SCI-GROW a method of comprehensive assessment developed by us has been used. It is based on establishing of maximum possible daily intake of pesticide with water and subsequently comparing with acceptable daily intake of pesticide with water. It was established that in soil and climatic conditions of Ukraine for most of the test substances probability of leaching into groundwater is negligible; in conditions of other European countries – risk of leaching is low. Maximum possible concentration of the test herbicides in groundwater are insignificant and are much lower of acceptable, which is associated primarily with low application rates and indicates relative safety for human health intakes such water.Key words: groundwater, herbicides, risk, maximal concentration, allowable intake.  ПОРІВНЯЛЬНА ГІГІЄНІЧНА ОЦІНКА РИЗИКУ ЗАБРУДНЕННЯ ПІДЗЕМНИХ ВОД ГЕРБІЦИДАМИ РІЗНИХ КЛАСІВ ТА ПРОГНОЗ НЕБЕЗПЕКИ ДЛЯ ЛЮДИНИ ПРИ СПОЖИВАННІ ЗАБРУДНЕНОЇ ВОДИ А. М. Антонечко,  О. П. Вавріневич, C. Т. Омельчук, М. М. Коршун Національний медичний університет імені О.О. БогомольцяКафедра гігієни та екології У статті представлені порівняльні результати гігієнічної оцінки ризику забруднення підземних вод гербіцидами різних хімічних класів і прогнозування небезпеки для людини при вживанні забрудненої води; надані рекомендації щодо застосування таких гербіцидівКлючові слова: ґрунтові води, гербіциди, ризик, максимальна концентрація, допустиме надходження

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