246 research outputs found
Interpolatory methods for model reduction of multi-input/multi-output systems
We develop here a computationally effective approach for producing
high-quality -approximations to large scale linear
dynamical systems having multiple inputs and multiple outputs (MIMO). We extend
an approach for model reduction introduced by Flagg,
Beattie, and Gugercin for the single-input/single-output (SISO) setting, which
combined ideas originating in interpolatory -optimal model
reduction with complex Chebyshev approximation. Retaining this framework, our
approach to the MIMO problem has its principal computational cost dominated by
(sparse) linear solves, and so it can remain an effective strategy in many
large-scale settings. We are able to avoid computationally demanding
norm calculations that are normally required to monitor
progress within each optimization cycle through the use of "data-driven"
rational approximations that are built upon previously computed function
samples. Numerical examples are included that illustrate our approach. We
produce high fidelity reduced models having consistently better
performance than models produced via balanced truncation;
these models often are as good as (and occasionally better than) models
produced using optimal Hankel norm approximation as well. In all cases
considered, the method described here produces reduced models at far lower cost
than is possible with either balanced truncation or optimal Hankel norm
approximation
Non-resonant dot-cavity coupling and its applications in resonant quantum dot spectroscopy
We present experimental investigations on the non-resonant dot-cavity
coupling of a single quantum dot inside a micro-pillar where the dot has been
resonantly excited in the s-shell, thereby avoiding the generation of
additional charges in the QD and its surrounding. As a direct proof of the pure
single dot-cavity system, strong photon anti-bunching is consistently observed
in the autocorrelation functions of the QD and the mode emission, as well as in
the cross-correlation function between the dot and mode signals. Strong Stokes
and anti-Stokes-like emission is observed for energetic QD-mode detunings of up
to ~100 times the QD linewidth. Furthermore, we demonstrate that non-resonant
dot-cavity coupling can be utilized to directly monitor and study relevant QD
s-shell properties like fine-structure splittings, emission saturation and
power broadening, as well as photon statistics with negligible background
contributions. Our results open a new perspective on the understanding and
implementation of dot-cavity systems for single-photon sources, single and
multiple quantum dot lasers, semiconductor cavity quantum electrodynamics, and
their implementation, e.g. in quantum information technology.Comment: 17 pages, 4 figure
Tunable Indistinguishable Photons From Remote Quantum Dots
Single semiconductor quantum dots have been widely studied within devices
that can apply an electric field. In the most common system, the low energy
offset between the InGaAs quantum dot and the surrounding GaAs material limits
the magnitude of field that can be applied to tens of kVcm^-1, before carriers
tunnel out of the dot. The Stark shift experienced by the emission line is
typically 1 meV. We report that by embedding the quantum dots in a quantum well
heterostructure the vertical field that can be applied is increased by over an
order of magnitude whilst preserving the narrow linewidths, high internal
quantum efficiencies and familiar emission spectra. Individual dots can then be
continuously tuned to the same energy allowing for two-photon interference
between remote, independent, quantum dots
Electro-elastic tuning of single particles in individual self-assembled quantum dots
We investigate the effect of uniaxial stress on InGaAs quantum dots in a
charge tunable device. Using Coulomb blockade and photoluminescence, we observe
that significant tuning of single particle energies (~ -0.5 meV/MPa) leads to
variable tuning of exciton energies (+18 to -0.9 micro-eV/MPa) under tensile
stress. Modest tuning of the permanent dipole, Coulomb interaction and
fine-structure splitting energies is also measured. We exploit the variable
exciton response to tune multiple quantum dots on the same chip into resonance.Comment: 16 pages, 4 figures, 1 table. Final versio
Mice expressing a human KATP channel mutation have altered channel ATP sensitivity but no cardiac abnormalities
AIMS/HYPOTHESIS: Patients with severe gain-of-function mutations in the Kir6.2 subunit of the ATP-sensitive potassium (K(ATP)) channel, have neonatal diabetes, muscle hypotonia and mental and motor developmental delay-a condition known as iDEND syndrome. However, despite the fact that Kir6.2 forms the pore of the cardiac K(ATP) channel, patients show no obvious cardiac symptoms. The aim of this project was to use a mouse model of iDEND syndrome to determine whether iDEND mutations affect cardiac function and cardiac K(ATP) channel ATP sensitivity. METHODS: We performed patch-clamp and in vivo cine-MRI studies on mice in which the most common iDEND mutation (Kir6.2-V59M) was targeted to cardiac muscle using Cre-lox technology (m-V59M mice). RESULTS: Patch-clamp studies of isolated cardiac myocytes revealed a markedly reduced K(ATP) channel sensitivity to MgATP inhibition in m-V59M mice (IC(50) 62 μmol/l compared with 13 μmol/l for littermate controls). In vivo cine-MRI revealed there were no gross morphological differences and no differences in heart rate, end diastolic volume, end systolic volume, stroke volume, ejection fraction, cardiac output or wall thickening between m-V59M and control hearts, either under resting conditions or under dobutamine stress. CONCLUSIONS/INTERPRETATION: The common iDEND mutation Kir6.2-V59M decreases ATP block of cardiac K(ATP) channels but was without obvious effect on heart function, suggesting that metabolic changes fail to open the mutated channel to an extent that affects function (at least in the absence of ischaemia). This may have implications for the choice of sulfonylurea used to treat neonatal diabetes
Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis
Background More than 10 years have elapsed since human papillomavirus (HPV) vaccination was implemented. We did a systematic review and meta-analysis of the population-level impact of vaccinating girls and women against human papillomavirus on HPV infections, anogenital wart diagnoses, and cervical intraepithelial neoplasia grade 2+ (CIN2+)to summarise the most recent evidence about the effectiveness of HPV vaccines in real-world settings and to quantify the impact of multiple age-cohort vaccination.Methods In this updated systematic review and meta-analysis, we used the same search strategy as in our previous paper. We searched MEDLINE and Embase for studies published between Feb 1, 2014, and Oct 11, 2018. Studies were eligible if they compared the frequency (prevalence or incidence) of at least one HPV-related endpoint (genital HPV infections, anogenital wart diagnoses, or histologically confirmed CIN2+) between pre-vaccination and post-vaccination periods among the general population and if they used the same population sources and recruitment methods before and after vaccination. Our primary assessment was the relative risk (RR) comparing the frequency (prevalence or incidence) of HPV-related endpoints between the pre-vaccination and post-vaccination periods. We stratified all analyses by sex, age, and years since introduction of HPV vaccination. We used random-effects models to estimate pooled relative risks.Findings We identified 1702 potentially eligible articles for this systematic review and meta-analysis, and included 65 articles in 14 high-income countries: 23 for HPV infection, 29 for anogenital warts, and 13 for CIN2+.After 5\u20138 years of vaccination, the prevalence of HPV 16 and 18 decreased significantly by 83% (RR 0\ub717, 95% CI 0\ub711\u20130\ub725) among girls aged 13\u201319 years, and decreased significantly by 66% (RR 0\ub734, 95% CI 0\ub723\u20130\ub749) among women aged 20\u201324 years. The prevalence of HPV 31, 33, and 45 decreased significantly by 54% (RR 0\ub746, 95% CI 0\ub733\u20130\ub766) among girls aged 13\u201319 years. Anogenital wart diagnoses decreased significantly by 67% (RR 0\ub733, 95% CI 0\ub724\u20130\ub746) among girls aged 15\u201319 years, decreased significantly by 54% (RR 0\ub746, 95% CI 0.36\u20130.60) among women aged 20\u201324 years, and decreased significantly by 31% (RR 0\ub769, 95% CI 0\ub753\u20130\ub789) among women aged 25\u201329 years. Among boys aged 15\u201319 years anogenital wart diagnoses decreased significantly by 48% (RR 0\ub752, 95% CI 0\ub737\u20130\ub775) and among men aged 20\u201324 years they decreased significantly by 32% (RR 0\ub768, 95% CI 0\ub747\u20130\ub798). After 5\u20139 years of vaccination, CIN2+ decreased significantly by 51% (RR 0\ub749, 95% CI 0\ub742\u20130\ub758) among screened girls aged 15\u201319 years and decreased significantly by 31% (RR 0\ub769, 95% CI 0\ub757\u20130\ub784) among women aged 20\u201324 years.Interpretation This updated systematic review and meta-analysis includes data from 60 million individuals and up to 8 years of post-vaccination follow-up. Our results show compelling evidence of the substantial impact of HPV vaccination programmes on HPV infections and CIN2+ among girls and women, and on anogenital warts diagnoses among girls, women, boys, and men. Additionally, programmes with multi-cohort vaccination and high vaccination coverage had a greater direct impact and herd effects
Engineering of quantum dot photon sources via electro-elastic fields
The possibility to generate and manipulate non-classical light using the
tools of mature semiconductor technology carries great promise for the
implementation of quantum communication science. This is indeed one of the main
driving forces behind ongoing research on the study of semiconductor quantum
dots. Often referred to as artificial atoms, quantum dots can generate single
and entangled photons on demand and, unlike their natural counterpart, can be
easily integrated into well-established optoelectronic devices. However, the
inherent random nature of the quantum dot growth processes results in a lack of
control of their emission properties. This represents a major roadblock towards
the exploitation of these quantum emitters in the foreseen applications. This
chapter describes a novel class of quantum dot devices that uses the combined
action of strain and electric fields to reshape the emission properties of
single quantum dots. The resulting electro-elastic fields allow for control of
emission and binding energies, charge states, and energy level splittings and
are suitable to correct for the quantum dot structural asymmetries that usually
prevent these semiconductor nanostructures from emitting polarization-entangled
photons. Key experiments in this field are presented and future directions are
discussed.Comment: to appear as a book chapter in a compilation "Engineering the
Atom-Photon Interaction" published by Springer in 2015, edited by A.
Predojevic and M. W. Mitchel
Incidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury-Laboratory Confirmed Bloodstream Infections in the First 100 Days after Allogeneic Hematopoietic Stem Cell Transplant
Importance: Patients undergoing hematopoietic stem cell transplant (HSCT) are at risk for bloodstream infection (BSI) secondary to translocation of bacteria through the injured mucosa, termed mucosal barrier injury-laboratory confirmed bloodstream infection (MBI-LCBI), in addition to BSI secondary to indwelling catheters and infection at other sites (BSI-other). Objective: To determine the incidence, timing, risk factors, and outcomes of patients who develop MBI-LCBI in the first 100 days after HSCT. Design, Setting, and Participants: A case-cohort retrospective analysis was performed using data from the Center for International Blood and Marrow Transplant Research database on 16875 consecutive pediatric and adult patients receiving a first allogeneic HSCT from January 1, 2009, to December 31, 2016. Patients were classified into 4 categories: MBI-LCBI (1481 [8.8%]), MBI-LCBI and BSI-other (698 [4.1%]), BSI-other only (2928 [17.4%]), and controls with no BSI (11768 [69.7%]). Statistical analysis was performed from April 5 to July 17, 2018. Main Outcomes and Measures: Demographic characteristics and outcomes, including overall survival, chronic graft-vs-host disease, and transplant-related mortality (only for patients with malignant disease), were compared among groups. Results: Of the 16875 patients in the study (9737 [57.7%] male; median [range] age, 47 [0.04-82] years) 13686 (81.1%) underwent HSCT for a malignant neoplasm, and 3189 (18.9%) underwent HSCT for a nonmalignant condition. The cumulative incidence of MBI-LCBI was 13% (99% CI, 12%-13%) by day 100, and the cumulative incidence of BSI-other was 21% (99% CI, 21%-22%) by day 100. Median (range) time from transplant to first MBI-LCBI was 8 (<1 to 98) days vs 29 (<1 to 100) days for BSI-other. Multivariable analysis revealed an increased risk of MBI-LCBI with poor Karnofsky/Lansky performance status (hazard ratio [HR], 1.21 [99% CI, 1.04-1.41]), cord blood grafts (HR, 2.89 [99% CI, 1.97-4.24]), myeloablative conditioning (HR, 1.46 [99% CI, 1.19-1.78]), and posttransplant cyclophosphamide graft-vs-host disease prophylaxis (HR, 1.85 [99% CI, 1.38-2.48]). One-year mortality was significantly higher for patients with MBI-LCBI (HR, 1.81 [99% CI, 1.56-2.12]), BSI-other (HR, 1.81 [99% CI, 1.60-2.06]), and MBI-LCBI plus BSI-other (HR, 2.65 [99% CI, 2.17-3.24]) compared with controls. Infection was more commonly reported as a cause of death for patients with MBI-LCBI (139 of 740 [18.8%]), BSI (251 of 1537 [16.3%]), and MBI-LCBI plus BSI (94 of 435 [21.6%]) than for controls (566 of 4740 [11.9%]). Conclusions and Relevance: In this cohort study, MBI-LCBI, in addition to any BSIs, were associated with significant morbidity and mortality after HSCT. Further investigation into risk reduction should be a clinical and scientific priority in this patient population
Voltage-Dependent Gating in a “Voltage Sensor-Less” Ion Channel
An unusual mechanism of ion channel regulation generates voltage-dependent gating in the absence of a canonical voltage-sensing domain
Planets Around Low-Mass Stars (PALMS). V. Age-Dating Low-Mass Companions to Members and Interlopers of Young Moving Groups
Copyright © 2015. The American Astronomical Society. All rights reserved.We present optical and near-infrared adaptive optics (AO) imaging and spectroscopy of 13 ultracool (>M6) companions to late-type stars (K7-M4.5), most of which have recently been identified as candidate members of nearby young moving groups (YMGs; 8-120 Myr) in the literature. The inferred masses of the companions (~10-100 Mjup) are highly sensitive to the ages of the primary stars so we critically examine the kinematic and spectroscopic properties of each system to distinguish bona fide YMG members from old field interlopers. 2MASS J02155892-0929121 C is a new M7 substellar companion (40-60 Mjup) with clear spectroscopic signs of low gravity and hence youth. The primary, possibly a member of the ~40 Myr Tuc-Hor moving group, is visually resolved into three components, making it a young low-mass quadruple system in a compact (1 Gyr) tidally-locked spectroscopic binaries without convincing kinematic associations with any known moving group. The high rate of false positives in the form of old active stars with YMG-like kinematics underscores the importance of radial velocity and parallax measurements to validate candidate young stars identified via proper motion and activity selection alone. Finally, we spectroscopically confirm the cool temperature and substellar nature of HD 23514 B, a recently discovered M8 benchmark brown dwarf orbiting the dustiest-known member of the Pleiades.NASANSFMt. Cuba Astronomical FoundationSamuel OschinAlfred P. Sloan Foundatio
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