Radio frequency association of heteronuclear Feshbach molecules

We present a detailed analysis of the production efficiency of weakly bound heteronuclear KRb-Feshbach molecules using radio frequency association in a harmonic trap. The efficiency was measured in a wide range of temperatures, binding energies and radio frequencies. A comprehensive analytical model is presented, explaining the observed asymmetric spectra and achieving good quantitative agreement with the measured production rates. This model provides a deep understanding of the molecule association process and paves the way for future experiments which rely on Feshbach molecules e.g. for the production of deeply bound molecules.Comment: 5 pages, 4 figure

Parametric amplification of vacuum fluctuations in a spinor condensate

Parametric amplification of vacuum fluctuations is crucial in modern quantum optics, enabling the creation of squeezing and entanglement. We demonstrate the parametric amplification of vacuum fluctuations for matter waves using a spinor F=2 Rb-87 condensate. Interatomic interactions lead to correlated pair creation in the m_F= +/- 1 states from an initial unstable m_F=0 condensate, which acts as a vacuum for m_F unequal 0. Although this pair creation from a pure m_F=0 condensate is ideally triggered by vacuum fluctuations, unavoidable spurious initial m_F= +/- 1 atoms induce a classical seed which may become the dominant triggering mechanism. We show that pair creation is insensitive to a classical seed for sufficiently large magnetic fields, demonstrating the dominant role of vacuum fluctuations. The presented system thus provides a direct path towards the generation of non-classical states of matter on the basis of spinor condensates.Comment: 5 pages, 4 figure

Multi-resonant spinor dynamics in a Bose-Einstein condensate

We analyze the spinor dynamics of a Rb-87 F=2 condensate initially prepared in the m_F=0 Zeeman sublevel. We show that this dynamics, characterized by the creation of correlated atomic pairs in m_F=+/-1, presents an intriguing multi-resonant magnetic field dependence induced by the trap inhomogeneity. This dependence is directly linked to the most unstable Bogoliubov spin excitations of the initial m_F = 0 condensate, showing that, in general, even a qualitative understanding of the pair creation efficiency in a spinor condensate requires a careful consideration of the confinement.Comment: 5 pages, 4 figure

Alpha-1-antitrypsin phenotypes in adult liver disease patients

Alpha-1-antitrypsin (AAT) is an important serine protease inhibitor in humans. Hereditary alpha-1-antitrypsin deficiency (AATD) affects lungs and liver. Liver disease caused by AATD in paediatric patients has been previously well documented. However, the association of liver disease with alpha-1-antitrypsin gene polymorphisms in adults is less clear. Therefore, we aimed to study AAT polymorphisms in adults with liver disease. We performed a case-control study. AAT polymorphisms were investigated by isoelectric focusing in 61 patients with liver cirrhosis and 9 patients with hepatocellular carcinoma. The control group consisted of 218 healthy blood donors. A significant deviation of observed and expected frequency of AAT phenotypes from Hardy-Weinberg equilibrium (chi-square = 34.77, df 11, P = 0.000) in the patient group was caused by a higher than expected frequency of Pi ZZ homozygotes (f = 0.0143 and f = 0.0005, respectively, P = 0.000). In addition, Pi M homozygotes were more frequent in patients than in controls (63% and 46%, respectively, P = 0.025). Our study results show that Pi ZZ homozygosity in adults could be associated with severe liver disease. Presence of Pi M homozygosity could be associated with liver disease via some mechanism different from Z allele-induced liver damage through accumulation of AAT polymers

Identification of a rare p.G320R alpha-1-antitrypsin variant in emphysema and lung cancer patients

The alpha-1-antitrypsin (A1AT) gene is highly polymorphic, with more than 100 genetic variants identified of which some can affect A1AT protein concentration and/or function and lead to pulmonary and/or liver disease. This study reports on the characterization of a p.G320R variant found in two patients, one with emphysema and the other with lung cancer. This variant results from a single base-pair substitution in exon 4 of the A1AT gene, and has been characterized as P by isoelectric focusing. Functional evaluation of the A1AT p.G320R variant was through comparing specific trypsin inhibitory activity in two patients with pulmonary disorders, carriers of the p.G320R variant, and 19 healthy individuals, carriers of normal A1AT M variants. Results showed that specific trypsin inhibitory activity was lower in both emphysema (2.45 mU/g) and lung cancer (2.07 mU/g) patients than in carriers of the normal variants (range 2.51-3.71 mU/g). This rare A1AT variant is associated with reduced functional activity of A1AT protein. Considering that it was found in patients with severe pulmonary disorders, this variant could be of clinical significance

Textured interfaces in monolithic perovskite silicon tandem solar cells advanced light management for improved efficiency and energy yield

Efficient light management in monolithic perovskite silicon tandem solar cells is one of the prerequisites for achieving high power conversion efficiencies PCEs . Textured silicon wafers can be utilized for light management, however, this is typically not compatible with perovskite solution processing. Here, we instead employ a textured light management LM foil on the front side of a tandem solar cell processed on a wafer with planar front side and textured back side. This way the PCE of monolithic, 2 terminal perovskite silicon heterojunction tandem solar cells is significantly improved from 23.4 to 25.5 . Furthermore, we validate an advanced numerical model for our fabricated device and use it to optically optimize a number of device designs with textures at different interface with respect to the PCE and energy yield. These simulations predict a slightly lower optimal bandgap of the perovskite top cell in a textured device as compared to a flat one and demonstrate strong interdependency between the bandgap and the texture position in the monolithic stack. We estimate the PCE potential for the best performing both side textured device to be 32.5 for a perovskite bandgap of 1.66 eV. Furthermore, the results show that under perpendicular illumination conditions, for optimized designs, the LM foil on top of the cell performs only slightly better than a flat anti reflective coating. However, under diffuse illumination, the benefits of the LM foil are much greater. Finally, we calculate the energy yield for the different device designs, based on true weather data for three different locations throughout the year, taking direct as well as diffuse illumination fully into account. The results further confirm the benefits of front side texture, even more for BIPV applications. Overall, devices built on a both side textured silicon wafer perform best. However, we show that devices with textured LM foils on the cell s front side are a highly efficient alternativ

27.9 Efficient Monolithic Perovskite Silicon Tandem Solar Cells on Industry Compatible Bottom Cells

Monolithic perovskite silicon tandem solar cells recently surpass the efficiency of silicon single junction solar cells. Most tandem cells utilize gt;250 amp; 8201; amp; 956;m thick, planarized float zone FZ silicon, which is not compatible with commercial production using lt;200 amp; 8201; amp; 956;m thick Czochralski CZ silicon. The perovskite silicon tandem cells based on industrially relevant 100 amp; 8201; amp; 956;m thick CZ silicon without mechanical planarization are demonstrated. The best power conversion efficiency PCE of 27.9 is only marginally below the 28.2 reference value obtained on the commonly used front side polished FZ Si, which are about three times thicker. With both wafer types showing the same median PCE of 27.8 , the thin CZ Si based devices are preferred for economic reasons. To investigate perspectives for improved current matching and, therefore, further efficiency improvement, optical simulations with planar and textured silicon have been conducted the perovskite s bandgap needs to be increased by amp; 8776;0.02 amp; 8201;eV when reducing the silicon thickness from 280 to 100 amp; 8201; amp; 956;m. The need for bandgap enlargement has a strong impact on future tandem developments ensuring photostable compositions with lossless interfaces at bandgaps around or above 1.7 amp; 8201;e

Proteome sequence features carry signatures of the environmental niche of prokaryotes

<p>Abstract</p> <p>Background</p> <p>Prokaryotic environmental adaptations occur at different levels within cells to ensure the preservation of genome integrity, proper protein folding and function as well as membrane fluidity. Although specific composition and structure of cellular components suitable for the variety of extreme conditions has already been postulated, a systematic study describing such adaptations has not yet been performed. We therefore explored whether the environmental niche of a prokaryote could be deduced from the sequence of its proteome. Finally, we aimed at finding the precise differences between proteome sequences of prokaryotes from different environments.</p> <p>Results</p> <p>We analyzed the proteomes of 192 prokaryotes from different habitats. We collected detailed information about the optimal growth conditions of each microorganism. Furthermore, we selected 42 physico-chemical properties of amino acids and computed their values for each proteome. Further, on the same set of features we applied two fundamentally different machine learning methods, Support Vector Machines and Random Forests, to successfully classify between bacteria and archaea, halophiles and non-halophiles, as well as mesophiles, thermophiles and mesothermophiles. Finally, we performed feature selection by using Random Forests.</p> <p>Conclusions</p> <p>To our knowledge, this is the first time that three different classification cases (domain of life, halophilicity and thermophilicity) of proteome adaptation are successfully performed with the same set of 42 features. The characteristic features of a specific adaptation constitute a signature that may help understanding the mechanisms of adaptation to extreme environments.</p

Benefits of protected areas for nonbreeding waterbirds adjusting their distributions under climate warming

Climate warming is driving changes in species distributions and community composition. Many species have a so-called climatic debt, that is, shifts in range lag behind shifts in temperature isoclines. Inside protected areas (PAs), community changes in response to climate warming can be facilitated by greater colonization rates by warm-dwelling species, but also mitigated by lowering extirpation rates of cold-dwelling species. An evaluation of the relative importance of colonization-extirpation processes is important to inform conservation strategies that aim for both climate debt reduction and species conservation. We assessed the colonization-extirpation dynamics involved in community changes in response to climate inside and outside PAs. To do so, we used 25 years of occurrence data of nonbreeding waterbirds in the western Palearctic (97 species, 7071 sites, 39 countries, 1993-2017). We used a community temperature index (CTI) framework based on species thermal affinities to investigate species turnover induced by temperature increase. We determined whether thermal community adjustment was associated with colonization by warm-dwelling species or extirpation of cold-dwelling species by modeling change in standard deviation of the CTI (CTISD). Using linear mixed-effects models, we investigated whether communities in PAs had lower climatic debt and different patterns of community change than communities outside PAs. For CTI and CTISD combined, communities inside PAs had more species, higher colonization, lower extirpation, and lower climatic debt (16%) than communities outside PAs. Thus, our results suggest that PAs facilitate 2 independent processes that shape community dynamics and maintain biodiversity. The community adjustment was, however, not sufficiently fast to keep pace with the large temperature increases in the central and northeastern western Palearctic. Our results underline the potential of combining CTI and CTISD metrics to improve understanding of the colonization-extirpation patterns driven by climate warming