132 research outputs found
Novel critical field in magneto-resistance oscillation of 2DEG in asymmetric GaAs/AlGaAs double wells measured as a function of the in-plane magnetic field
We have investigated the magnetoresistance of strongly asymmetric double-well
structures formed by a thin AlGaAs barrier grown far from the interface in the
GaAs buffer of standard heterostructures. In magnetic fields oriented parallel
to the electron layers, the magnetoresistance exhibits an oscillation
associated with the depopulation of the higher occupied subband and with the
field-induced transition into a decoupled bilayer. In addition, the increasing
field transfers electrons from the triangular to rectangular well and, at high
enough field value, the triangular well is emptied. Consequently, the
electronic system becomes a single layer which leads to a sharp step in the
density of electron states and to an additional minimum in the
magnetoresistance curve.Comment: 3 pages, 3 figure
Phylogenetic relationships in the family Alloherpesviridae
Phylogenetic relationships among herpesviruses (HVs) of mammals, birds, and reptiles have been studied extensively, whereas those among other HVs are relatively unexplored. We have reconstructed the phylogenetic relationships among 13 fish and amphibian HVs using maximum likelihood and Bayesian analyses of amino acid sequences predicted from parts of the DNA polymerase and terminase genes. The relationships among 6 of these viruses were confirmed using the partial DNA polymerase data plus the complete sequences of the terminase, helicase, and triplex protein genes; the position of these viruses among all other sequenced HVs was also investigated using the complete terminase gene. The results established the monophyly of the fish and amphibian HVs (Alloherpesviridae) separate from the HVs of mammals, birds, and reptiles (Herpesviridae) and the single recognized HV of bivalve mollusks (Malacoherpesviridae) in the order Herpesvirales. Two major clades in the family Alloherpesviridae were recognized: one consisting of viruses from cyprinid and anguillid hosts and the other of viruses from ictalurid, salmonid, acipenserid, and ranid hosts. A comparison of virus and host phylogenies suggested that closely related HVs in this family may have coevolved with their hosts, whereas significant codiversification was not apparent for the more distantly related viruses
Magnetoresistance and electronic structure of asymmetric GaAs/AlGaAs double quantum wells in the in-plane/tilted magnetic field
Bilayer two-dimensional electron systems formed by a thin barrier in the GaAs
buffer of a standard heterostructure were investigated by magnetotransport
measurements. In magnetic fields oriented parallel to the electron layers, the
magnetoresistance exhibits an oscillation associated with the depopulation of
the higher occupied subband and the field-induced transition into a decoupled
bilayer. Shubnikov-de Haas oscillations in slightly tilted magnetic fields
allow to reconstruct the evolution of the electron concentration in the
individual subbands as a function of the in-plane magnetic field. The
characteristics of the system derived experimentally are in quantitative
agreement with numerical self-consistent-field calculations of the electronic
structure.Comment: 6 pages, 5 figure
Temperature-Dependence of the Resistivity of a Dilute 2D Electron System in High Parallel Magnetic Field
We report measurements of the resistance of silicon MOSFETs as a function of
temperature in high parallel magnetic fields where the 2D system of electrons
has been shown to be fully spin-polarized. A magnetic field suppresses the
metallic behavior observed in the absence of a magnetic field. In a field of
10.8 T, insulating behavior is found for densities up to n_s approximately 1.35
x 10^{11} cm^{-2} or 1.5 n_c; above this density the resistance is a very weak
function of temperature, varying less than 10% between 0.25 K and 1.90 K. At
low densities the resistance goes to infinity more rapidly as the temperature
is reduced than in zero field and the magnetoresistance diverges as T goes to
0.Comment: 4 pages, including 4 figures. References adde
Parallel Magnetic Field Induced Transition in Transport in the Dilute Two-Dimensional Hole System in GaAs
A magnetic field applied parallel to the two-dimensional hole system in the
GaAs/AlGaAs heterostructure, which is metallic in the absence of an external
magnetic field, can drive the system into insulating at a finite field through
a well defined transition. The value of resistivity at the transition is found
to depend strongly on density
Improvement of Write Efficiency in Voltage-Controlled Spintronic Memory by development of a Ta-B Spin Hall Electrode
Magnetoresistance of one-dimensional subbands in tunnel-coupled double quantum wires
We study the low-temperature in-plane magnetoresistance of tunnel-coupled quasi-one-dimensional quantum wires. The wires are defined by two pairs of mutually aligned split gates on opposite sides of a < 1 micron thick AlGaAs/GaAs double quantum well heterostructure, allowing independent control of their widths. In the ballistic regime, when both wires are defined and the field is perpendicular to the current, a large resistance peak at ~6 Tesla is observed with a strong gate voltage dependence. The data is consistent with a counting model whereby the number of subbands crossing the Fermi level changes with field due to the formation of an anticrossing in each pair of 1D subbands
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
Aire regulates medullary epithelial cell production of XCL1, a chemoattractant for XCR1-expressing thymic DCs whose presence in the medulla contributes to the generation of T reg cells
Epidermal growth factor mediates detachment from and invasion through collagen I and Matrigel in Capan-1 pancreatic cancer cells
BACKGROUND: Pancreatic adenocarcinoma is a highly invasive neoplasm. Epidermal growth factor (EGF) and its receptor are over expressed in pancreatic cancer, and expression correlates with invasion and metastasis. We hypothesized that EGF receptor and integrin signalling pathways interact in mediating cellular adhesion and invasion in pancreatic cancer, and that invasiveness correlates temporally with detachment from extracellular matrix. METHODS: We tested this hypothesis by investigating the role of EGF in mediating adhesion to and invasion through collagen I and Matrigel in the metastatic pancreatic adenocarcinoma cell line Capan-1. Adhesion and invasion were measured using in vitro assays of fluorescently-labeled cells. Adhesion and invasion assays were also performed in the primary pancreatic adenocarcinoma cell line MIA PaCa-2. RESULTS: EGF inhibited adhesion to collagen I and Matrigel in Capan-1 cells. The loss of adhesion was reversed by AG825, an inhibitor of erbB2 receptor signalling and by wortmannin, a PI3K inhibitor, but not by the protein synthesis inhibitor cycloheximide. EGF stimulated invasion through collagen I and Matrigel at concentrations and time courses similar to those mediating detachment from these extracellular matrix components. Adhesion to collagen I was different in MIA PaCa-2 cells, with no significant change elicited following EGF treatment, whereas treatment with the EGF family member heregulin-alpha elicited a marked increase in adhesion. Invasion through Matrigel in response to EGF, however, was similar to that observed in Capan-1 cells. CONCLUSION: An inverse relationship exists between adhesion and invasion capabilities in Capan-1 cells but not in MIA PaCa-2 cells. EGF receptor signalling involving the erbB2 and PI3K pathways plays a role in mediating these events in Capan-1 cells
Enhanced Neointima Formation Following Arterial Injury in Immune Deficient Rag-1−/− Mice Is Attenuated by Adoptive Transfer of CD8+ T cells
T cells modulate neointima formation after arterial injury but the specific T cell population that is activated in response to arterial injury remains unknown. The objective of the study was to identify the T cell populations that are activated and modulate neointimal thickening after arterial injury in mice. Arterial injury in wild type C57Bl6 mice resulted in T cell activation characterized by increased CD4+CD44hi and CD8+CD44hi T cells in the lymph nodes and spleens. Splenic CD8+CD25+ T cells and CD8+CD28+ T cells, but not CD4+CD25+ and CD4+CD28+ T cells, were also significantly increased. Adoptive cell transfer of CD4+ or CD8+ T cells from donor CD8−/− or CD4−/− mice, respectively, to immune-deficient Rag-1−/− mice was performed to determine the T cell subtype that inhibits neointima formation after arterial injury. Rag-1−/− mice that received CD8+ T cells had significantly reduced neointima formation compared with Rag-1−/− mice without cell transfer. CD4+ T cell transfer did not reduce neointima formation. CD8+ T cells from CD4−/− mice had cytotoxic activity against syngeneic smooth muscle cells in vitro. The study shows that although both CD8+ T cells and CD4+ T cells are activated in response to arterial injury, adoptive cell transfer identifies CD8+ T cells as the specific and selective cell type involved in inhibiting neointima formation
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