Molecular Targets for Gastric Cancer Treatment and Future Perspectives from a Clinical and Translational Point of View

Gastric cancer is a leading cause of cancer death worldwide. Systemic treatment comprising chemotherapy and targeted therapy is the standard of care in advanced/metastatic gastric cancer. Comprehensive molecular characterization of gastric adenocarcinomas by the TCGA Consortium and ACRG has resulted in the definition of distinct molecular subtypes. These efforts have in parallel built a basis for the development of novel molecularly stratified treatment approaches. Based on this molecular characterization, an increasing number of specific genomic alterations can potentially serve as treatment targets. Consequently, the development of promising compounds is ongoing. In this review, key molecular alterations in gastric and gastroesophageal junction cancers will be addressed. Finally, the current status of the translation of targeted therapy towards clinical applications will be reviewed

The Twitter parliamentarian database: Analyzing Twitter politics across 26 countries

This article introduces the Twitter Parliamentarian Database (TPD), a multi-source and manually validated database of parliamentarians on Twitter. The TPD includes parliamentarians from all European Free Trade Association countries where over 45% of parliamentarians are on Twitter as well as a selection of English-speaking countries. The database is designed to move beyond the one-off nature of most Twitter-based research and in the direction of systematic and rigorous comparative and transnational analysis. The TPD incorporates, in addition to data collected through Twitter\u27s streaming API and governmental websites, data from the Manifesto Project Database; the Electoral System Design Database; the ParlGov database; and the Chapel Hill Expert Survey. By compiling these different data sources it becomes possible to compare different countries, political parties, political party families, and different kinds of democracies. To illustrate the opportunities for comparative and transnational analysis that the TPD opens up, we ask: What are the differences between countries in parliamentarian Twitter interactions? How do political parties differ in their use of hashtags and what is their common ground? What is the structure of interaction between parliamentarians in the transnational debate? Alongside some interesting similarities, we find striking cross-party and particularly cross-national differences in how parliamentarians engage in politics on the social media platform

pyerrors: a python framework for error analysis of Monte Carlo data

We present the pyerrors python package for statistical error analysis of Monte Carlo data. Linear error propagation using automatic differentiation in an object oriented framework is combined with the $\Gamma$-method for a reliable estimation of autocorrelation times. Data from different sources can easily be combined, keeping the information on the origin of error components intact throughout the analysis. pyerrors can be smoothly integrated into the existing scientific python ecosystem which allows for efficient and compact analyses.Comment: 22 pages, 2 figures, version accepted for publication in Computer Physics Communication

Optimal Phase Description of Chaotic Oscillators

We introduce an optimal phase description of chaotic oscillations by generalizing the concept of isochrones. On chaotic attractors possessing a general phase description, we define the optimal isophases as Poincar\'e surfaces showing return times as constant as possible. The dynamics of the resultant optimal phase is maximally decoupled of the amplitude dynamics, and provides a proper description of phase resetting of chaotic oscillations. The method is illustrated with the R\"ossler and Lorenz systems.Comment: 10 Pages, 14 Figure

An event-related potential study of cross-modal morphological and phonological priming

The current work investigated whether differences in phonological overlap between the past- and present-tense forms of regular and irregular verbs can account for the graded neurophysiological effects of verb regularity observed in past-tense priming designs. Event-related potentials were recorded from 16 healthy participants who performed a lexical-decision task in which past-tense primes immediately preceded present-tense targets. To minimize intra-modal phonological priming effects, cross-modal presentation between auditory primes and visual targets was employed, and results were compared to a companion intra-modal auditory study (Justus, T., Larsen, J., de Mornay Davies, P., Swick, D. (2008). Interpreting dissociations between regular and irregular past-tense morphology: evidence from event-related potentials. Cognitive, Affective, Behavioral Neuroscience, 8, 178–194.). For both regular and irregular verbs, faster response times and reduced N400 components were observed for present-tense forms when primed by the corresponding past-tense forms. Although behavioral facilitation was observed with a pseudopast phonological control condition, neither this condition nor an orthographic-phonological control produced significant N400 priming effects. Instead, these two types of priming were associated with a post-lexical anterior negativity (PLAN). Results are discussed with regard to dual- and single-system theories of inflectional morphology, as well as intra- and cross-modal prelexical priming