Application of natural antioxidants in the composition of gel "Imbirol" for rhinitis of different genesis

One of the stages of the pathophysiological study of the state of the prooxidant-antioxidant system under the conditions of modeling different types of rhinitis in rats was carried out. The experiment took 36 rats, with bacterial and chemical rhinitis, with treatment and without it. Indicators of peroxidation of lipids and antioxidant system were determined in serum: thiobarbituric acid (TBA) and diene conjugates (DK), reduced glutathione (RG) and catalase (Cat). The obtained research results confirmed the formation of oxidative stress in experimental groups, both in chemical and bacterial rhinitis, according to DK and TBA data at 168.3%, 216.1% (chemical) and 159.4%, 216.1% (at bacterial) compared to intact animals. Imbirol shows pronounced therapeutic antioxidant properties in comparison with the reference preparation Pinosol. The effectiveness of the new gel "Imbirol" has a more positive dynamics of AOS restoration in blood serum when developing experimental rhinitis and does not differ significantly from the parameters of the reference preparation "Pinosol". In the pathogenesis of chemical and bacterial rhinitis, the violation of the antioxidant-antioxidant system is installed at the system level. Application of powerful universal treatment with gel "Imbirol" in both types of experimental rhinitis contributes to the normalization of the indicators of the system "peroxidation-antioxidant protection". The applying of the gel "Imbirol" in chemical and bacterial rhinitis reliably led to the restoration of the excited AOS parameters at the systemic level by reducing the concentration of TBA and DC and increasing the activity of the enzymes of catalase and RG. The obtained results allow to continue the study of the influence of antioxidants in experimental rhinitis, and mechanisms of restoration of the nasal mucosa under the pharmacological influence of the gel "Imbirol"

ЕКСПЕРИМЕНТАЛЬНЕ ОБГРУНТУВАННЯ СКЛАДУ ТА ВИВЧЕННЯ ТОКСИКОЛОГІЧНИХ ПОКАЗНИКІВ НОВОГО СТОМАТОЛОГІЧНОГО ГЕЛЮ НА ОСНОВІ ЛІЗОЦИМУ ГІДРОХЛОРИДУ = EXPERIMENTAL SUBSTANTIATION COMPOSITION AND INVESTIGATION TOXICOLOGOCAL ENDEPOINT NEW DENTAL GEL BASED ON LYSOZYME HYDROCHLORIDE = ЭКСПЕРИМЕНТАЛЬНОЕ ОБОСНОВАНИЕ СОСТАВА И ИЗУЧЕНИЕ ТОКСИКОЛОГИЧЕСКИХ ПОКАЗАТЕЛЕЙ НОВОГО СТОМАТОЛОГИЧЕСКОГО ГЕЛЯ НА ОСНОВЕ ЛИЗОЦИМА ГИДРОХЛОРИДА

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.10.2016. Revised 02.10.2016. Accepted: 30.10.2016. УДК 616. 31­002:616. 311. 2­002:616. 314. 17­008. 1:616­08 ЕКСПЕРИМЕНТАЛЬНЕ ОБГРУНТУВАННЯ СКЛАДУ ТА ВИВЧЕННЯ ТОКСИКОЛОГІЧНИХ ПОКАЗНИКІВ НОВОГО СТОМАТОЛОГІЧНОГО ГЕЛЮ НА ОСНОВІ ЛІЗОЦИМУ ГІДРОХЛОРИДУ Н. С. Кавушевська, А. І. Березнякова, Т. І. Тюпка Національний фармацевтичний університет, м. Харків Резюме Шляхом експериментальних досліджень анти ексудативної активності 9 зразків гелю на основі лізоциму гідрохлориду на моделях карагенінового набряку було визначено оптимальний склад нового стоматологічного гелю для лікування запальних захворювань м’яких тканин пародонту – гель №2 (0,3% лізоциму гідрохлорид, 2,0% гідроксіетилцелюлоза), дана композиція отримала умовну назву «Лізостом». Згідно з класифікацією к. К. Сидорова гель «Лізостом» відноситься до VI класу токсичності. Ключові слова: лізоциму гідрохлорид, стоматологічний гель, антиексудативна активність. EXPERIMENTAL SUBSTANTIATION COMPOSITION AND INVESTIGATION TOXICOLOGOCAL ENDEPOINT NEW DENTAL GEL BASED ON LYSOZYME HYDROCHLORIDE N. S. Kavushevska, A. I. Bereznyarova, T. I. Tyupka National University of Pharmacy, Kharkiv Summary Through experimental research of antiexudation activity of 9 samples of a gel based on the lysozyme hydrochloride on the carragenin edema models was determined the optimal composition of the new dental gel for the treatment of inflammatory diseases of the soft periodontal tissues – gel № 2 (0. 3% lysozyme hydrochloride, 2. 0% hydroxyethylcellulose) and named “Lizostom”. According to the k. k. Sidorov’s classification the selected gel “Lizostom” sample belongs to the 4th class of toxicity. Key words: lysozyme hydrochloride, dental gel, antiexudation activity