Strong-Field-Driven Electron Dynamics near an Ionization Threshold

Excitation of atoms with light that spectrally spans across the ionization threshold leads to free electrons initially located close to the parent ions. The dynamics of these ionized electrons driven by external light fields are studied by transient-absorption spectroscopy on helium in this thesis. Implementing an ab initio simulation, the time-dependent Schrödinger equation (TDSE) is solved for a model atom, giving direct access to the strong-field-driven evolution of the electron's wave function. In a separate theoretical approach, absorption spectra are calculated based on classical trajectories. Experimentally, an extension of a transient-absorption beamline allowed polarization-dependent measurements. The recorded absorption spectra of helium, depending on the intensity of a superimposed near-infrared femtosecond laser pulse with both linear and circular polarization, are presented and discussed. The observed absorption features can be assigned to two intensity regimes. For moderate intensities, light-induced states adequately explain the observed structures in the absorption spectra in agreement with the TDSE simulations. For higher laser intensities, the photon picture breaks down and the analysis of the dipole moment in the time domain suggests an interpretation in terms of classical electron trajectories. The combined theoretical and experimental investigation provides access to regimes in which the classical description of strong-field-driven electron dynamics emerges

Edge Intersection Graphs of L-Shaped Paths in Grids

In this paper we continue the study of the edge intersection graphs of one (or zero) bend paths on a rectangular grid. That is, the edge intersection graphs where each vertex is represented by one of the following shapes: $\llcorner$,$\ulcorner$, $\urcorner$, $\lrcorner$, and we consider zero bend paths (i.e., | and $-$) to be degenerate $\llcorner$s. These graphs, called $B_1$-EPG graphs, were first introduced by Golumbic et al (2009). We consider the natural subclasses of $B_1$-EPG formed by the subsets of the four single bend shapes (i.e., {$\llcorner$}, {$\llcorner$,$\ulcorner$}, {$\llcorner$,$\urcorner$}, and {$\llcorner$,$\ulcorner$,$\urcorner$}) and we denote the classes by [$\llcorner$], [$\llcorner$,$\ulcorner$], [$\llcorner$,$\urcorner$], and [$\llcorner$,$\ulcorner$,$\urcorner$] respectively. Note: all other subsets are isomorphic to these up to 90 degree rotation. We show that testing for membership in each of these classes is NP-complete and observe the expected strict inclusions and incomparability (i.e., [$\llcorner$] $\subsetneq$ [$\llcorner$,$\ulcorner$], [$\llcorner$,$\urcorner$] $\subsetneq$ [$\llcorner$,$\ulcorner$,$\urcorner$] $\subsetneq$ $B_1$-EPG; also, [$\llcorner$,$\ulcorner$] is incomparable with [$\llcorner$,$\urcorner$]). Additionally, we give characterizations and polytime recognition algorithms for special subclasses of Split $\cap$ [$\llcorner$].Comment: 14 pages, to appear in DAM special issue for LAGOS'1

EPG-representations with small grid-size

In an EPG-representation of a graph $G$ each vertex is represented by a path in the rectangular grid, and $(v,w)$ is an edge in $G$ if and only if the paths representing $v$ an $w$ share a grid-edge. Requiring paths representing edges to be x-monotone or, even stronger, both x- and y-monotone gives rise to three natural variants of EPG-representations, one where edges have no monotonicity requirements and two with the aforementioned monotonicity requirements. The focus of this paper is understanding how small a grid can be achieved for such EPG-representations with respect to various graph parameters. We show that there are $m$-edge graphs that require a grid of area $\Omega(m)$ in any variant of EPG-representations. Similarly there are pathwidth-$k$ graphs that require height $\Omega(k)$ and area $\Omega(kn)$ in any variant of EPG-representations. We prove a matching upper bound of $O(kn)$ area for all pathwidth-$k$ graphs in the strongest model, the one where edges are required to be both x- and y-monotone. Thus in this strongest model, the result implies, for example, $O(n)$, $O(n \log n)$ and $O(n^{3/2})$ area bounds for bounded pathwidth graphs, bounded treewidth graphs and all classes of graphs that exclude a fixed minor, respectively. For the model with no restrictions on the monotonicity of the edges, stronger results can be achieved for some graph classes, for example an $O(n)$ area bound for bounded treewidth graphs and $O(n \log^2 n)$ bound for graphs of bounded genus.Comment: Appears in the Proceedings of the 25th International Symposium on Graph Drawing and Network Visualization (GD 2017

Multiscale Modeling of Influenza A Virus Infection Supports the Development of Direct-Acting Antivirals

Influenza A viruses are respiratory pathogens that cause seasonal epidemics with up to 500,000 deaths each year. Yet there are currently only two classes of antivirals licensed for treatment and drug-resistant strains are on the rise. A major challenge for the discovery of new anti-influenza agents is the identification of drug targets that efficiently interfere with viral replication. To support this step, we developed a multiscale model of influenza A virus infection which comprises both the intracellular level where the virus synthesizes its proteins, replicates its genome, and assembles new virions and the extracellular level where it spreads to new host cells. This integrated modeling approach recapitulates a wide range of experimental data across both scales including the time course of all three viral RNA species inside an infected cell and the infection dynamics in a cell population. It also allowed us to systematically study how interfering with specific steps of the viral life cycle affects virus production. We find that inhibitors of viral transcription, replication, protein synthesis, nuclear export, and assembly/release are most effective in decreasing virus titers whereas targeting virus entry primarily delays infection. In addition, our results suggest that for some antivirals therapy success strongly depends on the lifespan of infected cells and, thus, on the dynamics of virus-induced apoptosis or the host's immune response. Hence, the proposed model provides a systems-level understanding of influenza A virus infection and therapy as well as an ideal platform to include further levels of complexity toward a comprehensive description of infectious diseases

Cliophysics: Socio-political Reliability Theory, Polity Duration and African Political (In)stabilities

Quantification of historical sociological processes have recently gained attention among theoreticians in the effort of providing a solid theoretical understanding of the behaviors and regularities present in sociopolitical dynamics. Here we present a reliability theory of polity processes with emphases on individual political dynamics of African countries. We found that the structural properties of polity failure rates successfully capture the risk of political vulnerability and instabilities in which 87.50%, 75%, 71.43%, and 0% of the countries with monotonically increasing, unimodal, U-shaped and monotonically decreasing polity failure rates, respectively, have high level of state fragility indices. The quasi-U-shape relationship between average polity duration and regime types corroborates historical precedents and explains the stability of the autocracies and democracies.Comment: 4 pages, 3 figures, 1 tabl

Requirement of a Membrane Potential for the Posttranslational Transfer of Proteins into Mitochondsria

Posttranslational transfer of most precursor proteins into mitochondria is dependent on energization of the mitochondria. Experiments were carried out to determine whether the membrane potential or the intramitochondrial ATP is the immediate energy source. Transfer in vitro of precursors to the ADP/ATP carrier and to ATPase subunit 9 into isolated Neurospora mitochondria was investigated. Under conditions where the level of intramitochondrial ATP was high and the membrane potential was dissipated, import and processing of these precursor proteins did not take place. On the other hand, precursors were taken up and processed when the intramitochondrial ATP level was low, but the membrane potential was not dissipated. We conclude that a membrane potential is involved in the import of those mitochondrial precursor proteins which require energy for intracellular translocatio

Inhomogeneous point-process entropy: an instantaneous measure of complexity in discrete systems

Measures of entropy have been widely used to characterize complexity, particularly in physiological dynamical systems modeled in discrete time. Current approaches associate these measures to finite single values within an observation window, thus not being able to characterize the system evolution at each moment in time. Here, we propose a new definition of approximate and sample entropy based on the inhomogeneous point-process theory. The discrete time series is modeled through probability density functions, which characterize and predict the time until the next event occurs as a function of the past history. Laguerre expansions of the Wiener-Volterra autoregressive terms account for the long-term nonlinear information. As the proposed measures of entropy are instantaneously defined through probability functions, the novel indices are able to provide instantaneous tracking of the system complexity. The new measures are tested on synthetic data, as well as on real data gathered from heartbeat dynamics of healthy subjects and patients with cardiac heart failure and gait recordings from short walks of young and elderly subjects. Results show that instantaneous complexity is able to effectively track the system dynamics and is not affected by statistical noise properties