gamma Doradus pulsation in two pre-main sequence stars discovered by CoRoT

Pulsations in pre-main sequence stars have been discovered several times within the last years. But nearly all of these pulsators are of delta Scuti-type. gamma Doradus-type pulsation in young stars has been predicted by theory, but lack observational evidence. We present the investigation of variability caused by rotation and (gammaDoradus-type) pulsation in two pre-main sequence members of the young open cluster NGC2264 using high-precision time series photometry from the CoRoT satellite and dedicated high-resolution spectroscopy. Time series photometry of NGC2264VAS20 and NGC 2264VAS87 was obtained by the CoRoT satellite during the dedicated short run SRa01 in March 2008. NGC2264VAS87 was re-observed by CoRoT during the short run SRa05 in December 2011 and January 2012. Frequency analysis was conducted using Period04 and SigSpec. The spectral analysis was performed using equivalent widths and spectral synthesis. The frequency analysis yielded 10 and 14 intrinsic frequencies for NGC2264VAS20 and NGC2264VAS 87, respectively, in the range from 0 to 1.5c/d which are attributed to be caused by a combination of rotation and pulsation. The effective temperatures were derived to be 6380$\pm$150K for NGC2264VAS20 and 6220$\pm$150K for NGC2264VAS87. Membership of the two stars to the cluster is confirmed independently using X-ray fluxes, radial velocity measurements and proper motions available in the literature. The derived Li abundances of log n(Li)=3.34 and 3.54 for NGC2264VAS20 and NGC2264VAS87, respectively, are in agreement with the Li abundance for other stars in NGC2264 of similar Teff reported in the literature. We conclude that the two objects are members of NGC2264 and therefore are in their pre-main sequence evolutionary stage. Assuming that part of their variability is caused by pulsation, these two stars might be the first pre-main sequence gamma Doradus candidates.Comment: 11 pages, 10 figures, A&A accepte

Colorado Ultraviolet Transit Experiment Data Simulator

The Colorado Ultraviolet Transit Experiment (CUTE) is a 6U NASA CubeSat carrying on-board a low-resolution (R~2000--3000), near-ultraviolet (2500--3300 {\AA}) spectrograph. It has a rectangular primary Cassegrain telescope to maximize the collecting area. CUTE, which is planned for launch in Spring 2020, is designed to monitor transiting extra-solar planets orbiting bright, nearby stars aiming at improving our understanding of planet atmospheric escape and star-planet interaction processes. We present here the CUTE data simulator, which we complemented with a basic data reduction pipeline. This pipeline will be then updated once the final CUTE data reduction pipeline is developed. We show here the application of the simulator to the HD209458 system and a first estimate of the precision on the measurement of the transit depth as a function of temperature and magnitude of the host star. We also present estimates of the effect of spacecraft jitter on the final spectral resolution. The simulator has been developed considering also scalability and adaptability to other missions carrying on-board a long-slit spectrograph. The data simulator will be used to inform the CUTE target selection, choose the spacecraft and instrument settings for each observation, and construct synthetic CUTE wavelength-dependent transit light curves on which to develop the CUTE data reduction pipeline.Comment: Accepted for publication in the Journal of Astronomical Telescopes, Instruments and System

Association mapping of Stagonospora nodorum blotch resistance in modern European winter wheat varieties

Association mapping in populations relevant for wheat breeding has a large potential for validating and fine-mapping QTLs identified in F2- or DH (double haploid)-derived populations. In this study, associations between markers in the region of QSng.sfr-3BS, a major QTL for resistance to Stagonospora nodorum glume blotch (SNG), and SNG resistance were investigated by linkage and association analyses. After increasing marker density in 240 F5:7 recombinant inbred lines (RILs), QSng.sfr-3BS explained 43% of the genetic variance and peaked 0.6cM proximal from the marker SUN2-3B. Association between SNG resistance and markers mapped in the region of QSng.sfr-3BS was investigated in a population of 44 modern European winter wheat varieties. Two genetically distinct subpopulations were identified within these lines. In agreement with linkage analyses, association mapping by a least squares general linear model (GLM) at marker loci in the region of QSng.sfr-3BS revealed the highest association with SNG resistance for SUN2-3B (p<0.05). Association mapping can provide an effective mean of relating genotypes to complex quantitative phenotypes in hexaploid wheat. Linkage disequilibrium (r 2) in chromosome 3B extended less than 0.5cM in 44 varieties, while it extended about 30cM in 240 RILs, based on 91 SSR and STS marker-pair comparisons. This indicated that the association mapping population had a marker resolution potential at least 390-fold higher compared to the RIL populatio

Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer--results from two randomised studies

INTRODUCTION: Endometrial cancer patients with high grade tumours, deep myometrial invasion or advanced stage disease have a poor prognosis. Randomised studies have demonstrated the prevention of loco-regional relapses with radiotherapy (RT) with no effect on overall survival (OS). The possible additive effect of chemotherapy (CT) remains unclear. Two randomised clinical trials (NSGO-EC-9501/EORTC-55991 and MaNGO ILIADE-III) were undertaken to clarify if sequential combination of chemotherapy and radiotherapy improves progression-free survival (PFS) in high-risk endometrial cancer. The two studies were pooled. METHODS: Patients (n=540; 534 evaluable) with operated endometrial cancer International Federation of Obstetrics and Gynaecology (FIGO) stage I-III with no residual tumour and prognostic factors implying high-risk were randomly allocated to adjuvant radiotherapy with or without sequential chemotherapy. RESULTS: In the NSGO/EORTC study, the combined modality treatment was associated with 36% reduction in the risk for relapse or death (hazard ratio (HR) 0.64, 95%confidence interval (CI) 0.41-0.99; P=0.04); two-sided tests were used. The result from the Gynaecologic Oncology group at the Mario Negri Institute (MaNGO)-study pointed in the same direction (HR 0.61), but was not significant. In the combined analysis, the estimate of risk for relapse or death was similar but with narrower confidence limits (HR 0.63, CI 0.44-0.89; P=0.009). Neither study showed significant differences in the overall survival. In the combined analysis, overall survival approached statistical significance (HR 0.69, CI 0.46-1.03; P=0.07) and cancer-specific survival (CSS) was significant (HR 0.55, CI 0.35-0.88; P=0.01). CONCLUSION: Addition of adjuvant chemotherapy to radiation improves progression-free survival in operated endometrial cancer patients with no residual tumour and a high-risk profile. A remaining question for future studies is if addition of radiotherapy to chemotherapy improves the results