Estimation of Hydrodynamical Model Parameters from the Invariant Spectrum and the Bose-Einstein Correlations of pi-mesons Produced in (pi+/K+)p Interactions at 250 GeV/c

The invariant spectra of pi- mesons produced in (pi+/K+)p interactions at 250 GeV/c are analysed in the framework of the hydrodynamical model of three-dimensionally expanding cylindrically symmetric finite systems. A satisfactory description of experimental data is achieved. The data favour the pattern according to which the hadron matter undergoes predominantly longitudinal expansion and non-relativistic transverse expansion with mean transverse velocity = 0.20(7), and is characterized by a large temperature inhomogeneity in the transverse direction: the extracted freeze-out temperature at the center of the tube and at the transverse rms radius are 140(3) MeV and 82(7) MeV, respectively. The width of the (longitudinal) space-time rapidity distribution of the pion source is found to be Delta eta = 1.36(2). Combining this estimate with results of the Bose-Einstein correlation analysis in the same experiment, one extracts a mean freeze-out time of the source of = 1.4(1) fm/c and its transverse geometrical rms radius, R_G (rms)=1.2(2) fm.Comment: latex, 14 pages, 5 figure

On the Influence of Pulse Shapes on Ionization Probability

We investigate analytical expressions for the upper and lower bounds for the ionization probability through ultra-intense shortly pulsed laser radiation. We take several different pulse shapes into account, including in particular those with a smooth adiabatic turn-on and turn-off. For all situations for which our bounds are applicable we do not find any evidence for bound-state stabilization.Comment: 21 pages LateX, 10 figure

Estimation of hydrodynamical model parameters from the invariant spectrum and the Bose-Einstein correlations of π\pi-mesons produced in (π+/K+)p\pi^{+}/K^{+})p interactions at 250 GeV/c

The invariant spectra of pi- mesons produced in (pi+/K+)p interactions at 250 GeV/c are analysed in the framework of the hydrodynamical model of three-dimensionally expanding cylindrically symmetric finite systems. A satisfactory description of experimental data is achieved. The data favour the pattern according to which the hadron matter undergoes predominantly longitudinal expansion and non-relativistic transverse expansion with mean transverse velocity = 0.20(7), and is characterized by a large temperature inhomogeneity in the transverse direction: the extracted freeze-out temperature at the center of the tube and at the transverse rms radius are 140(3) MeV and 82(7) MeV, respectively. The width of the (longitudinal) space-time rapidity distribution of the pion source is found to be Delta eta = 1.36(2). Combining this estimate with results of the Bose-Einstein correlation analysis in the same experiment, one extracts a mean freeze-out time of the source of = 1.4(1) fm/c and its transverse geometrical rms radius, R_G (rms)=1.2(2) fm.The invariant spectra of pi- mesons produced in (pi+/K+)p interactions at 250 GeV/c are analysed in the framework of the hydrodynamical model of three-dimensionally expanding cylindrically symmetric finite systems. A satisfactory description of experimental data is achieved. The data favour the pattern according to which the hadron matter undergoes predominantly longitudinal expansion and non-relativistic transverse expansion with mean transverse velocity = 0.20(7), and is characterized by a large temperature inhomogeneity in the transverse direction: the extracted freeze-out temperature at the center of the tube and at the transverse rms radius are 140(3) MeV and 82(7) MeV, respectively. The width of the (longitudinal) space-time rapidity distribution of the pion source is found to be Delta eta = 1.36(2). Combining this estimate with results of the Bose-Einstein correlation analysis in the same experiment, one extracts a mean freeze-out time of the source of = 1.4(1) fm/c and its transverse geometrical rms radius, R_G (rms)=1.2(2) fm

Observation of narrow baryon resonance decaying into pKs0pK^0_s in pA-interactions at 70GeV/c70 GeV/c with SVD-2 setup

SVD-2 experiment data have been analyzed to search for an exotic baryon state, the $\Theta^+$-baryon, in a $pK^0_s$ decay mode at $70 GeV/c$ on IHEP accelerator. The reaction $pA \to pK^0_s+X$ with a limited multiplicity was used in the analysis. The $pK^0_s$ invariant mass spectrum shows a resonant structure with $M=1526\pm3(stat.)\pm 3(syst.) MeV/c^2$ and $\Gamma < 24 MeV/c^2$. The statistical significance of this peak was estimated to be of $5.6 \sigma$. The mass and width of the resonance is compatible with the recently reported $\Theta^+$- baryon with positive strangeness which was predicted as an exotic pentaquark ($uudd\bar{s}$) baryon state. The total cross section for $\Theta^+$ production in pN-interactions for $X_F\ge 0$ was estimated to be $(30\div120) \mu b$ and no essential deviation from A-dependence for inelastic events $(\sim A^{0.7})$ was found.Comment: 8 pages, 7 figures, To be submitted to Yadernaya Fizika. v3-v5 - Some references added, minor typos correcte

Partial ORF1ab Gene Target Failure with Omicron BA.2.12.1

Mutations in the genome of SARS-CoV-2 can affect the performance of molecular diagnostic assays. In some cases, such as S-gene target failure, the impact can serve as a unique indicator of a particular SARS-CoV-2 variant and provide a method for rapid detection. Here, we describe partial ORF1ab gene target failure (pOGTF) on the cobas SARS-CoV-2 assays, defined by a $2-thermocycle delay in detection of the ORF1ab gene compared to that of the E-gene. We demonstrate that pOGTF is 98.6% sensitive and 99.9% specific for SARS-CoV-2 lineage BA.2.12.1, an emerging variant in the United States with spike L452Q and S704L mutations that may affect transmission, infectivity, and/ or immune evasion. Increasing rates of pOGTF closely mirrored rates of BA.2.12.1 sequences uploaded to public databases, and, importantly, increasing local rates of pOGTF also mirrored increasing overall test positivity. Use of pOGTF as a proxy for BA.2.12.1 provides faster tracking of the variant than whole-genome sequencing and can benefit laboratories without sequencing capabilities

Functional Rotation of the Transporter AcrB: Insights into Drug Extrusion from Simulations

The tripartite complex AcrAB-TolC is the major efflux system in Escherichia coli. It extrudes a wide spectrum of noxious compounds out of the bacterium, including many antibiotics. Its active part, the homotrimeric transporter AcrB, is responsible for the selective binding of substrates and energy transduction. Based on available crystal structures and biochemical data, the transport of substrates by AcrB has been proposed to take place via a functional rotation, in which each monomer assumes a particular conformation. However, there is no molecular-level description of the conformational changes associated with the rotation and their connection to drug extrusion. To obtain insights thereon, we have performed extensive targeted molecular dynamics simulations mimicking the functional rotation of AcrB containing doxorubicin, one of the two substrates that were co-crystallized so far. The simulations, including almost half a million atoms, have been used to test several hypotheses concerning the structure-dynamics-function relationship of this transporter. Our results indicate that, upon induction of conformational changes, the substrate detaches from the binding pocket and approaches the gate to the central funnel. Furthermore, we provide strong evidence for the proposed peristaltic transport involving a zipper-like closure of the binding pocket, responsible for the displacement of the drug. A concerted opening of the channel between the binding pocket and the gate further favors the displacement of the drug. This microscopically well-funded information allows one to identify the role of specific amino acids during the transitions and to shed light on the functioning of AcrB

Стан слизової оболонки шлунка та її мікроциркуляторного русла в інтактній та перифокальній зоні при виразковій хворобі, що асоційована з HP

In the article there was presented an analysis of the own scientific data of the stomach mucous membrane state and the links of the vascular microcirculatory bed in norm and in intact and perifocal zones at the ulcerous disease (the localization of the ulcer in the pyloric region), it being accompanied with the colonization of the pyloric helicobacter; В статті представлений аналіз власних наукових даних про стан слизової оболонки шлунка та ланок кровоносного мікроциркуляторного русла в звичайному стані та в інтактній і перифокальній зонах при виразковій хворобі (локалізація виразки в пілорічному відділі), що супроводжується колонізацією шлунка пілоричним хелікобактером

Distribution maps of vegetation alliances in Europe

Aim The first comprehensive checklist of European phytosociological alliances, orders and classes (EuroVegChecklist) was published by Mucina et al. (2016, Applied Vegetation Science, 19 (Suppl. 1), 3–264). However, this checklist did not contain detailed information on the distribution of individual vegetation types. Here we provide the first maps of all alliances in Europe. Location Europe, Greenland, Canary Islands, Madeira, Azores, Cyprus and the Caucasus countries. Methods We collected data on the occurrence of phytosociological alliances in European countries and regions from literature and vegetation-plot databases. We interpreted and complemented these data using the expert knowledge of an international team of vegetation scientists and matched all the previously reported alliance names and concepts with those of the EuroVegChecklist. We then mapped the occurrence of the EuroVegChecklist alliances in 82 territorial units corresponding to countries, large islands, archipelagos and peninsulas. We subdivided the mainland parts of large or biogeographically heterogeneous countries based on the European biogeographical regions. Specialized alliances of coastal habitats were mapped only for the coastal section of each territorial unit. Results Distribution maps were prepared for 1,105 alliances of vascular-plant dominated vegetation reported in the EuroVegChecklist. For each territorial unit, three levels of occurrence probability were plotted on the maps: (a) verified occurrence; (b) uncertain occurrence; and (c) absence. The maps of individual alliances were complemented by summary maps of the number of alliances and the alliance–area relationship. Distribution data are also provided in a spreadsheet. Conclusions The new map series represents the first attempt to characterize the distribution of all vegetation types at the alliance level across Europe. There are still many knowledge gaps, partly due to a lack of data for some regions and partly due to uncertainties in the definition of some alliances. The maps presented here provide a basis for future research aimed at filling these gaps

Distribution maps of vegetation alliances in Europe

Aim The first comprehensive checklist of European phytosociological alliances, orders and classes (EuroVegChecklist) was published by Mucina et al. (2016, Applied Vegetation Science, 19 (Suppl. 1), 3–264). However, this checklist did not contain detailed information on the distribution of individual vegetation types. Here we provide the first maps of all alliances in Europe. Location Europe, Greenland, Canary Islands, Madeira, Azores, Cyprus and the Caucasus countries. Methods We collected data on the occurrence of phytosociological alliances in European countries and regions from literature and vegetation-plot databases. We interpreted and complemented these data using the expert knowledge of an international team of vegetation scientists and matched all the previously reported alliance names and concepts with those of the EuroVegChecklist. We then mapped the occurrence of the EuroVegChecklist alliances in 82 territorial units corresponding to countries, large islands, archipelagos and peninsulas. We subdivided the mainland parts of large or biogeographically heterogeneous countries based on the European biogeographical regions. Specialized alliances of coastal habitats were mapped only for the coastal section of each territorial unit. Results Distribution maps were prepared for 1,105 alliances of vascular-plant dominated vegetation reported in the EuroVegChecklist. For each territorial unit, three levels of occurrence probability were plotted on the maps: (a) verified occurrence; (b) uncertain occurrence; and (c) absence. The maps of individual alliances were complemented by summary maps of the number of alliances and the alliance–area relationship. Distribution data are also provided in a spreadsheet. Conclusions The new map series represents the first attempt to characterize the distribution of all vegetation types at the alliance level across Europe. There are still many knowledge gaps, partly due to a lack of data for some regions and partly due to uncertainties in the definition of some alliances. The maps presented here provide a basis for future research aimed at filling these gaps