The Yangian of sl(n|m) and the universal R-matrix

In this paper we study Yangians of sl(n|m) superalgebras. We derive the universal R-matrix and evaluate it on the fundamental representation obtaining the standard Yang R-matrix with unitary dressing factors. For m=0, we directly recover up to a CDD factor the well-known S-matrices for relativistic integrable models with su(N) symmetry. Hence, the universal R-matrix found provides an abstract plug-in formula, which leads to results obeying fundamental physical constraints: crossing symmetry, unitrarity and the Yang-Baxter equation. This implies that the Yangian double unifies all desired symmetries into one algebraic structure. In particular, our analysis is valid in the case of sl(n|n), where one has to extend the algebra by an additional generator leading to the algebra gl(n|n). We find two-parameter families of scalar factors in this case and provide a detailed study for gl(1|1).Comment: 24 pages, 2 figure

Controlling trapping potentials and stray electric fields in a microfabricated ion trap through design and compensation

Recent advances in quantum information processing with trapped ions have demonstrated the need for new ion trap architectures capable of holding and manipulating chains of many (>10) ions. Here we present the design and detailed characterization of a new linear trap, microfabricated with scalable complementary metal-oxide-semiconductor (CMOS) techniques, that is well-suited to this challenge. Forty-four individually controlled DC electrodes provide the many degrees of freedom required to construct anharmonic potential wells, shuttle ions, merge and split ion chains, precisely tune secular mode frequencies, and adjust the orientation of trap axes. Microfabricated capacitors on DC electrodes suppress radio-frequency pickup and excess micromotion, while a top-level ground layer simplifies modeling of electric fields and protects trap structures underneath. A localized aperture in the substrate provides access to the trapping region from an oven below, permitting deterministic loading of particular isotopic/elemental sequences via species-selective photoionization. The shapes of the aperture and radio-frequency electrodes are optimized to minimize perturbation of the trapping pseudopotential. Laboratory experiments verify simulated potentials and characterize trapping lifetimes, stray electric fields, and ion heating rates, while measurement and cancellation of spatially-varying stray electric fields permits the formation of nearly-equally spaced ion chains.Comment: 17 pages (including references), 7 figure

From Scattering Amplitudes to the Dilatation Generator in N=4 SYM

The complete spin chain representation of the planar N=4 SYM dilatation generator has long been known at one loop, where it involves leading nearest-neighbor 2 -> 2 interactions. In this work we use superconformal symmetry to derive the unique solution for the leading L -> 2 interactions of the planar dilatation generator for arbitrarily large L. We then propose that these interactions are given by the scattering operator that has N=4 SYM tree-level scattering amplitudes as matrix elements. We provide compelling evidence for this proposal, including explicit checks for L=2,3 and a proof of consistency with superconformal symmetry.Comment: 39 pages, v2: reference added and minor changes, published versio

Nonperturbative scales in AdS/CFT

The cusp anomalous dimension is a ubiquitous quantity in four-dimensional gauge theories, ranging from QCD to maximally supersymmetric N=4 Yang-Mills theory, and it is one of the best investigated observables in the AdS/CFT correspondence. In planar N=4 SYM theory, its perturbative expansion at weak coupling has a finite radius of convergence while at strong coupling it admits an expansion in inverse powers of the 't Hooft coupling which is given by a non-Borel summable asymptotic series. We study the cusp anomalous dimension in the transition regime from strong to weak coupling and argue that the transition is driven by nonperturbative, exponentially suppressed corrections. To compute these corrections, we revisit the calculation of the cusp anomalous dimension in planar N=4 SYM theory and extend the previous analysis by taking into account nonperturbative effects. We demonstrate that the scale parameterizing nonperturbative corrections coincides with the mass gap of the two-dimensional bosonic O(6) sigma model embedded into the AdS_5xS^5 string theory. This result is in agreement with the prediction coming from the string theory consideration.Comment: 49 pages, 1 figure; v2: minor corrections, references adde

Hematopoietic stem cell transplantation for adult patients with isolated NPM1 mutated acute myeloid leukemia in first remission

Acute myeloid leukemia (AML) in first remission (CR1) with isolated NPM1 mutation (iNPM1m) is considered a good prognosis genotype, although up to one-third relapse. To evaluate the best transplant strategy, we retrospectively compared autologous stem cell transplantation (auto-SCT), related (MSD), and fully matched unrelated (MUD) allogeneic stem cell transplantation (allo-SCT). We identified 256 adult patients including 125 auto-SCT, 72 MSD, and 59 MUD. The 2-year leukemia-free survival (LFS) was 62% in auto-SCT, 69% in MUD, and 81% in MSD (P = .02 for MSD vs others). The 2-year overall survival (OS) was not different among auto-SCT, MUD, and MSD, reaching 83% (P = .88). The 2-year non-relapse mortality (NRM) was 2.5% in auto-SCT and 7.5% in allo-SCT (P = .04). The 2-year cumulative incidence of relapse (RI) was higher after auto-SCT (30%) than after MUD (22%) and MSD (12%, P = .01). In multivariate analysis, MSD versus auto-SCT but not MUD versus auto-SCT was associated with lower RI (P < .01 and P = .13, respectively) and better LFS (P = .01 and P = .31, respectively). Age correlated with higher NRM (P < .01). Allo-SCT using MSD appears as a reasonable transplant option for young patients with iNPM1m AML in CR1. Auto-SCT was followed by worse RI and LFS, but similar OS to both allo-SCT modalities

Liver Transplantation because of Acute Liver Failure due to Heme Arginate Overdose in a Patient with Acute Intermittent Porphyria

In acute attacks of acute intermittent porphyria, the mainstay of treatment is glucose and heme arginate administration. We present the case of a 58-year-old patient with acute liver failure requiring urgent liver transplantation after erroneous 6-fold overdose of heme arginate during an acute attack. As recommended in the product information, albumin and charcoal were administered and hemodiafiltration was started, which could not prevent acute liver failure, requiring super-urgent liver transplantation after 6 days. The explanted liver showed no preexisting liver cirrhosis, but signs of subacute liver injury and starting regeneration. The patient recovered within a short time. A literature review revealed four poorly documented cases of potential hepatic and/or renal toxicity of hematin or heme arginate. This is the first published case report of acute liver failure requiring super-urgent liver transplantation after accidental heme arginate overdose. The literature and recommendations in case of heme arginate overdose are summarized. Knowledge of a potentially fatal course is important for the management of future cases. If acute liver failure in case of heme arginate overdose is progressive, super-urgent liver transplantation has to be evaluated

Quantum folded string and integrability: from finite size effects to Konishi dimension

Using the algebraic curve approach we one-loop quantize the folded string solution for the type IIB superstring in AdS(5)xS(5). We obtain an explicit result valid for arbitrary values of its Lorentz spin S and R-charge J in terms of integrals of elliptic functions. Then we consider the limit S ~ J ~ 1 and derive the leading three coefficients of strong coupling expansion of short operators. Notably, our result evaluated for the anomalous dimension of the Konishi state gives 2\lambda^{1/4}-4+2/\lambda^{1/4}. This reproduces correctly the values predicted numerically in arXiv:0906.4240. Furthermore we compare our result using some new numerical data from the Y-system for another similar state. We also revisited some of the large S computations using our methods. In particular, we derive finite--size corrections to the anomalous dimension of operators with small J in this limit.Comment: 20 pages, 1 figure; v2: references added, typos corrected; v3: major improvement of the references; v4: Discussion of short operators is restricted to the case n=1. This restriction does not affect the main results of the pape