314 research outputs found
Application of a new screening model to thermonuclear reactions of the rp process
A new screening model for astrophysical thermonuclear reactions was derived
recently which improved Salpeter's weak-screening one. In the present work we
prove that the new model can also give very reliable screening enhancement
factors (SEFs) when applied to the rp process. According to the results of the
new model, which agree well with Mitler's SEFs, the screened rp reaction rates
can be, at most, twice as fast as the unscreened ones.Comment: 8 RevTex pages + 7 ps figures. (Revised version). Accepted for
publication in Journal of Physics
Astrophysical factors:Zero energy vs. Most effective energy
Effective astrophysical factors for non-resonant astrophysical nuclear
reaction are invariably calculated with respect to a zero energy limit. In the
present work that limit is shown to be very disadvantageous compared to the
more natural effective energy limit. The latter is used in order to modify the
thermonuclear reaction rate formula so that it takes into account both plasma
and laboratory screening effects.Comment: 7 RevTex pages. Accepted for publication in Phys.Rev.
Atomic effects in astrophysical nuclear reactions
Two models are presented for the description of the electron screening
effects that appear in laboratory nuclear reactions at astrophysical energies.
The two-electron screening energy of the first model agrees very well with the
recent LUNA experimental result for the break-up reaction , which so far defies all available theoretical models.
Moreover, multi-electron effects that enhance laboratory reactions of the CNO
cycle and other advanced nuclear burning stages, are also studied by means of
the Thomas-Fermi model, deriving analytical formulae that establish a lower and
upper limit for the associated screening energy. The results of the second
model, which show a very satisfactory compatibility with the adiabatic
approximation ones, are expected to be particularly useful in future
experiments for a more accurate determination of the CNO astrophysical factors.Comment: 14 RevTex pages + 2 ps (revised) figures. Phys.Rev.C (in production
Screening enhancement factors for laboratory CNO and rp astrophysical reactions
Cross sections of laboratory CNO and rp astrophysical reactions are enhanced
due to the presence of the multi-electron cloud that surrounds the target
nuclei. As a result the relevant astrophysical factors are overestimated unless
corrected appropriately. This study gives both an estimate of the error
committed if screening effects are not taken into account and a rough profile
of the laboratory energy thresholds at which the screening effect appears. The
results indicate that, for most practical purposes, screening corrections to
past relevant experiments can be disregarded. Regarding future experiments,
however, screening corrections to the CNO reactions will certainly be of
importance as they are closely related to the solar neutrino fluxes and the rp
process. Moreover, according to the present results, screening effects will
have to be taken into account particularly by the current and future LUNA
experiments, where screened astrophysical factors will be enhanced to a
significant degree.Comment: 6 RevTex pages + 2 ps figures. (Revised version). Accepted for
publication in Journal of Physics
Association of combined PD- L1 expression and tumour- infiltrating lymphocyte features with survival and treatment outcomes in patients with metastatic melanoma
BackgroundRecent advances obtained with immune checkpoint inhibitors (ICIs) targeting the programmed cell death- 1 (PD- 1) protein have significantly improved the outcome of patients with metastatic melanoma. The PD- L1 expression in tumour cells as detected by immunohistochemistry is a predictive biomarker in some solid tumours, but appears insufficient as prognostic or predictive factor of response to ICIs in metastatic melanomas.ObjectivesWe investigated whether the presence and the features of pretreatment CD8+tumour- infiltrating T lymphocytes (TILs) could be a complementary prognostic or predictive biomarker in patients with metastatic melanoma.MethodsIn this retrospective study, we evaluated the association of PD- L1 expression - ¥5% of tumour cells combined with TIL features (CD8, CD28, Ki67) with the overall survival (OS) among 51 patients treated with ICIs and 54 patients treated with other treatment options (non- ICIs).ResultsPD- L1 positivity was observed in 33% and 39% of primary melanomas and matched metastases, respectively, with, however, poor concordance between the primary and the matched metastatic site (κ = 0.283). No significant association was noted between PD- L1 expression and CD8+TIL profile analysed as single markers and OS or response to immunotherapy. Instead, their combined analysis in primary melanoma samples showed that the PD- L1- /CD8+status was significantly associated with prolonged OS in the whole population (P = 0.04) and in the subgroup treated with non- ICIs (P = 0.009). Conversely, the PD- L1+/CD8+ status was a good prognostic factor in patients treated with ICIs (P = 0.022), whereas was significantly associated with poor prognosis in patients treated with non- ICIs (P = 0.014). While the expression of CD28 was not related to outcome, the Ki67 expression was significantly associated with poor OS in the subgroup CD8+TIL+/PD- L1- (P = 0.02).ConclusionsThe pretreatment combination of PD- L1 expression with the level of CD8+TILs could better assess OS and predict therapeutic response of patients with metastatic melanoma treated by either immunotherapy or other treatment regimens.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155478/1/jdv16016_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155478/2/jdv16016.pd
New solar axion search in CAST with He filling
The CERN Axion Solar Telescope (CAST) searches for conversion in
the 9 T magnetic field of a refurbished LHC test magnet that can be directed
toward the Sun. Two parallel magnet bores can be filled with helium of
adjustable pressure to match the X-ray refractive mass to the axion
search mass . After the vacuum phase (2003--2004), which is optimal for
eV, we used He in 2005--2007 to cover the mass range of
0.02--0.39 eV and He in 2009--2011 to scan from 0.39--1.17 eV. After
improving the detectors and shielding, we returned to He in 2012 to
investigate a narrow range around 0.2 eV ("candidate setting" of our
earlier search) and 0.39--0.42 eV, the upper axion mass range reachable with
He, to "cross the axion line" for the KSVZ model. We have improved the
limit on the axion-photon coupling to (95% C.L.), depending on the pressure settings. Since 2013, we
have returned to vacuum and aim for a significant increase in sensitivity.Comment: CAST Collaboration 6 pages 3 figure
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