Regional lexicography: zoological vocabulary in ideographic dictionary

In the article the working results on one section of the thematic dictionary of Samara dialects are summarized. The study is novel in the application of the ideographic description technique to the large lexical material, which was extracted from the unpublished files of dialectological expeditions in the villages of the Samara region. The author of the article reported that the language corps of vocabulary fixations was used as the main source of the thematic group of zoological vocabulary, which was compiled using the thematic questionnaire, given to respondents. The thematic zoological vocabulary was classified and divided into two main semantic blocks: Wild Animals and Home Animals.The author states that both semantic blocks represent complex system formations with developed differentiation of dialect nominations. Attention is drawn to the fact that the first block is dominated by the names of fish, birds, insects, and reptiles, while the most part of the second block consists of the animals and birds names grown in the household. In the Samara dialects there is a variety of word-formation dialect modifications of words, the presence of productive affixes. The author raises the question, if it is possible to represent systematically the names of individual members of the animal world, which were borrowed by Russians from the other languages of the Volga region people, in the dialect dictionary. The author claims that the material of the Samara dialects is optimally reflected in the dictionary compiled using the technique of ideographic description. The article concludes that the systemic connections identified as a result of the study in the thematic group of zoological names can be used in the complex characteristic of secondary dialects of the Volga region, along with the facts of other dialect languages levels

Dialect Lexicography: to the Problem of Thematic Presentation of Vocabulary of the Middle Volga Dialects

The results of work on a multi-aspect thematic dictionary of Samara dialects is summarized in the article. The novelty of the study is that the created dictionary is the first combined dialect dictionary in the region. It is reported that the language corpus of vocabulary fixations compiled by participants in dialectological expeditions using the methodology for presenting a thematic questionnaire to respondents is used as the main source of material for the thematic dictionary. The question is raised about the possibility of a systematic representation of the vocabulary of secondary dialects. The idea is proved that the thematic presentation of vocabulary material occupies an essential place in the complex characterization of the Volga dialects along with methods for presenting facts at other levels of the language (phonetic, morphological, etc.). The possibility of establishing classifying semantic and word-formation features is demonstrated in the example of separate thematic groups of the dictionary. Attention is drawn to the variety of word-formation formants in lexical-semantic groups, their role in the organization of a certain semantic space. It is concluded that the publication of a thematic dictionary offers great opportunities for the study of dialects of territories of late settlement in various aspects. The author of the article states that the thematic principle of the presentation of vocabulary material makes the structure of the dictionary open, the study of the lexical level of modern dialects is promising

Presentational Vocabulary of Samara Dialects

The specifics of the system-structural organization of presentational vocabulary in the Russian dialects of the Samara region is considered. Lexical materials of dialectological expeditions, supplementing the Volga Atlas, are used. The relevance of the study is determined by the importance of information about the originality of Russian folk dialects in the peripheral areas. The array of words indicating the names of the realities from the sphere of the household of a traditional Russian house is identified, the typology of dialect correspondences is defined. Generic-specific, variable and synonymic relations are examined. Special attention is paid to dialectal names from the point of view of the nominating and derivational components, organizing the thematic groups. The existence of dialectal variants of popular words and dialectal lexemes absent in the literary language and its varieties, the variety of principles and methods of nomination, the predominance of words with clear etymology is stated. It is shown that most of the dialectal lexemes denoting household items are all-Russian. It is established that locally limited vocabulary has typological similarities with the dialects of other areas of both polar dialectal groups of the Russian language. Group of local vocabulary that unites Samara dialects with the other dialects of the Volga region is identified. It is concluded that the study of the presentational vocabulary extends the idea of the typology of Samara secondary dialects

Discovering Business Area Effects to Process Mining Analysis Using Clustering and Influence Analysis

A common challenge for improving business processes in large organizations is that business people in charge of the operations are lacking a fact-based understanding of the execution details, process variants, and exceptions taking place in business operations. While existing process mining methodologies can discover these details based on event logs, it is challenging to communicate the process mining findings to business people. In this paper, we present a novel methodology for discovering business areas that have a significant effect on the process execution details. Our method uses clustering to group similar cases based on process flow characteristics and then influence analysis for detecting those business areas that correlate most with the discovered clusters. Our analysis serves as a bridge between BPM people and business, people facilitating the knowledge sharing between these groups. We also present an example analysis based on publicly available real-life purchase order process data.Comment: 12 pages. Paper accepted in 23rd International Conference on Business Information Systems (BIS 2020) to be published in a proceedings edition of the Lecture Notes in Business Information Processin

Efficacy and safety of rociletinib versus chemotherapy in patients with EGFR-mutated NSCLC: the results of TIGER-3, a phase 3 randomized study

Introduction: The TIGER-3 (NCT02322281) study was initiated to compare the efficacy and safety of rociletinib, a third-generation EGFR tyrosine kinase inhibitor (TKI) that targets EGFR T790M and common EGFR-activating mutations, versus chemotherapy in patients with NSCLC who progressed on first- or second-generation EGFR TKIs. Methods: Patients with advanced or metastatic EGFR-mutated NSCLC with disease progression on standard therapy (previous EGFR TKI and platinum-based chemotherapy) were randomized to oral rociletinib (500 or 625 mg twice daily) or single-agent chemotherapy (pemetrexed, gemcitabine, docetaxel, or paclitaxel). Results: Enrollment was halted when rociletinib development was discontinued in 2016. Of 149 enrolled patients, 75 were randomized to rociletinib (n = 53: 500 mg twice daily; n = 22: 625 mg twice daily) and 74 to chemotherapy. The median investigator-assessed progression-free survival (PFS) was 4.1 months (95% confidence interval [CI]: 2.6-5.4) in the rociletinib 500-mg group and 5.5 months (95% CI: 1.8-8.1) in the 625-mg group versus 2.5 months (95% CI: 1.4-2.9) in the chemotherapy group. An improved PFS was observed in patients with T790M-positive NSCLC treated with rociletinib (n = 25; 500 mg and 625 mg twice daily) versus chemotherapy (n = 20; 6.8 versus 2.7 mo; hazard ratio = 0.55, 95% CI: 0.28-1.07, p = 0.074). Grade 3 or higher hyperglycemia (24.0%), corrected QT prolongation (6.7%), diarrhea (2.7%), and vomiting (1.3%) were more frequent with rociletinib than chemotherapy (0%, 0%, 1.4%, and 0%, respectively). Conclusions: Rociletinib had a more favorable median PFS versus chemotherapy but had higher rates of hyperglycemia and corrected QT prolongation in patients with advanced EGFR-mutated NSCLC who progressed on previous EGFR TKI. Incomplete enrollment prevented evaluation of the primary efficacy end point

Stress-induced aggression in heterozygous TPH2 mutant mice is associated with alterations in serotonin turnover and expression of 5-HT6 and AMPA subunit 2A receptors

Background: The contribution of gene-environment interactions that lead to excessive aggression is poorly understood. Environmental stressors and mutations of the gene encoding tryptophan hydroxylase-2 (TPH2) are known to influence aggression. For example, TPH2 null mutant mice (Tph2−/−) are naturally highly aggressive, while heterozygous mice (Tph2+/−) lack a behavioral phenotype and are considered endophenotypically normal. Here we sought to discover whether an environmental stressor would affect the phenotype of the genetically ‘susceptible’ heterozygous mice (Tph2+/−). Methods: Tph2+/− male mice or Tph2+/+ controls were subjected to a five-day long rat exposure stress paradigm. Brain serotonin metabolism and the expression of selected genes encoding serotonin receptors, AMPA receptors, and stress markers were studied. Results: Stressed Tph2+/− mice displayed increased levels of aggression and social dominance, whereas Tph2+/+ animals became less aggressive and less dominant. Brain tissue concentrations of serotonin, its precursor hydroxytryptophan and its metabolite 5-hydroxyindoleacetic acid were significantly altered in all groups in the prefrontal cortex, striatum, amygdala, hippocampus and dorsal raphe after stress. Compared to non-stressed animals, the concentration of 5-hydroxytryptophan was elevated in the amygdala though decreased in the other brain structures. The overexpression of the AMPA receptor subunit, GluA2, and downregulation of 5-HT6 receptor, as well as overexpression of c-fos and glycogen-synthase-kinase-3β (GSK3-β), were found in most structures of the stressed Tph2+/− mice. Limitations: Rescue experiments would help to verify causal relationships of reported changes. Conclusions: The interaction of a partial TPH2 gene deficit with stress results in pathological aggression and molecular changes, and suggests that the presence of genetic susceptibility can augment aggression in seemingly resistant phenotypes. © 2020 The Authors602805Seventh Framework Programme, FP7Deutsche Forschungsgemeinschaft, DFG: CRC TRR 58 A1/A5Horizon 2020 Framework Programme, H2020: 728018Russian Foundation for Basic Research, RFBR: 15-04-03602Deutsche Forschungsgemeinschaft, DFGRussian Foundation for Basic Research, RFBRThe authors’ work reported here was supported Deutsche Forschungsgemeinschaft (DFG: CRC TRR 58 A1/A5), the European Union's Seventh Framework Programme (FP7/2007–2013) under Grant No. 602805 (Aggressotype) and the Horizon 2020 Research and Innovation Programme under Grant No. 728018 (Eat2beNICE) (to KPL and TS), the “5-100” Russian Academic Excellence Project (to KPL and TS) and the Russian Foundation of Basic Research (RFBR Grant No. 15-04-03602 to TS). We appreciate the valuable technical help of Dr. Joao Costa-Nunes and Dolores Bonopartos with this project

Neonates’ responses to repeated exposure to a still face

The main aims of the study were to examine whether human neonates' responses to communication disturbance modelled by the still-face paradigm were stable and whether their responses were affected by their previous experience with the still-face paradigm.The still face procedure, as a laboratory model of interpersonal stress, was administered repeatedly, twice, to 84 neonates (0 to 4 day olds), with a delay of an average of 1.25 day.Frame-by-frame analysis of the frequency and duration of gaze, distressed face, crying, sleeping and sucking behaviours showed that the procedure was stressful to them both times, that is, the still face effect was stable after repeated administration and newborns consistently responded to such nonverbal violation of communication. They averted their gaze, showed distress and cried more during the still-face phase in both the first and the second administration. They also showed a carry-over effect in that they continued to avert their gaze and displayed increased distress and crying in the first reunion period, but their gaze behaviour changed with experience, in the second administration. While in the first administration the babies continued averting their gaze even after the stressful still-face phase was over, this carry-over effect disappeared in the second administration, and the babies significantly increased their gaze following the still-face phase.After excluding explanations of fatigue, habituation and random effects, a self-other regulatory model is discussed as a possible explanation for this pattern