PRIMARY HYPERPARATHYROIDISM AT THE BACKGROUND OF PARATHYROID GLAND HYPERPLASIA. PECULIARITIES AND DIFFICULTIES OF DIAGNOSTICS

The article uses a clinical case of primary hyperparathyroidism in young patient with hyperplastic parathyroid gland localization in tissues of thyroid gland as an example to study the matters of cytological, histological, clinical and laboratory diagnostics of such pathology. It provides a literature reference on the difficulties of establishing a cytological and histological diagnoses, sets out the peculiarities of morphological pattern, discusses the tactical matters of primary hyperparathyroidism management, indications for surgical treatment and case follow-up of patients

The use of Kuraderm drug in the treatment of basal cell carcinoma of the head and neck

Basal cell carcinoma is one of the most common malignancies. Despite a wide range of treatment options and relatively good prognosis of the disease, there may be restrictions on the use of standard methods of treatment because of elderly patients, their physical condition and characteristics of the tumor localization. We provide clinical examples of successful treatment of basal cell carcinoma of the head and neck with Kuraderm BEC5. This is a drug with anti-tumor activity for topical use made on the basis of glycoalkaloids of plants of nightshade family

Focused radiofrequency treatment of postpartum vaginal relaxation syndrome

Aim: to assess the efficacy and safety of non-ablative radiofrequency treatment in the postpartum period in patients with vaginal relaxation syndrome and other initial manifestations of pelvic floor dysfunction (PFD).Materials and Methods. 44 patients with complaints of the initial manifestations of PFD were enrolled into prospective randomized comparative study: 30 women in the main group and 14 in the control group. Diagnostic methods included medical history collection, objective examination, assessing condition of the perineum by visual inspection; standard clinical and laboratory studies; using the questionnaire for calculating the Female Sexual Function Index (FSFI-19). Staging of pelvic organ prolapse was performed according to the POP-Q classification (Pelvic Organ Prolapse Quantification system). Measurement of the pelvic floor muscle contraction strength was performed by using a perineometer. A course of 3 procedures of radiofrequency non-ablative exposure of the vulvovaginal tissues in patients from the main group was performed 2 months after delivery, with 7-day interval. Assessment of the collagenogenesis and neoangiogenesis was carried out base on measuring expression level of the mRNA specific to proteins of the vaginal connective tissue by using real-time polymerase chain reaction.Results. Our study allowed to find that anatomical and functional state of the vulvovaginal area and perineum were significantly improved as well as relief of PFD symptoms. The level of expression of decorin mRNA in patients from the main group before and after treatment were 0.1 ± 0.035 and 0.047 ± 0.002, respectively (p = 0.02, Wilcoxon t-test). The median values of mRNA expression of matrix metalloproteinase type 2 before and after treatment were 0.0177 and 0.013, respectively (p = 0.03). The expression of type III collagen mRNA before and after treatment was 0.0675 and 0.0109, respectively (p = 0.03).Conclusion. The data obtained by us demonstrate positive effects after using monopolar radiofrequency therapy on the tissues in the vulva, vagina and perineum of patients in the postpartum period. However, clinical improvement in patients with PFD represents a cumulative result of morphological and functional changes in the tissues of the perineum as well as vulvovaginal region. We believe it is irrational to associate such positive effects solely with altered magnitude of the metabolism of collagen and other extracellular matrix proteins, due to dynamic balance and genetic determinism of decay and production of connective tissue proteins. The safety and role of radiofrequency therapeutic procedures in prevention and treatment of PFD require further investigation by assessing new markers and research methods, by extending observation period as well as increasing amount and quality of clinical observations

СASE STUDY OF OVARIAN VEIN THROMBOSIS DURING PREGNANCY AT 24 WEEKS OF GESTATION

In article the question is a case of ovarian vein thrombosis, developed in pregnant woman at 24 weeks of pregnancy, describing therapy and further treatment tactics, delivery and sorts of outcome

CLINICAL CASE OF EXTRAUTERINE PREGNANCY, LOCATED IN RUDIMENTAL UTERINE HORN AT 21-22 WEEK OF GESTATION

In article the question is a case of extrauterine pregnancy in term of 21-22 weeks in the rudimentary horn of a uterus in term of 21-22 weeks interrupted because of break of a horn with an intrabelly bleeding. The operation and tactical approaches to conducting the given case are described

Crystal structure and Hirshfeld surface analysis of 2-amino-4-(4-methoxyphenyl)-6-oxo-1-phenyl-1,4,5,6-tetrahydropyridine-3-carbonitrile

The central tetrahydropyridine ring of the title compound, C19H17N3O2, adopts a screw-boat conformation. In the crystal, strong C-H center dot center dot center dot O and N-H center dot center dot center dot N hydrogen bonds form dimers with R-2(2)(14) and R-2(2)(12) ring motifs, respectively, between consecutive molecules along the c-axis direction. Intermolecular N-H center dot center dot center dot O and C-H center dot center dot center dot O hydrogen bonds connect these dimers, forming a three-dimensional network. C-H center dot center dot center dot pi interactions and pi-pi stacking interactions contribute to the stabilization of the molecular packing. A Hirshfeld surface analysis indicates that the contributions from the most prevalent interactions are H center dot center dot center dot H (47.1%), C center dot center dot center dot H/H center dot center dot center dot C (20.9%), O center dot center dot center dot H/H center dot center dot center dot O (15.3%) and N center dot center dot center dot H/H center dot center dot center dot N (11.4%)

Prophylaxis of рurulent-septic diseases of postpartum period for high-risk puerperas

Background. Postpartum purulent-septic diseases are one of the topical issues of modern obstetrics due to high prevalence and absence of downward trend toward reduction in the disease incidence.Objective: improve the management of high risk puerperas to prevent the development of purulent-septic complications in the postpartum period.Materials and methods. The cohort prospective comparative study included 78 puerperas, who experienced spontaneous labour complicated by injuries to birth canals. The patients were divided into two groups according to the risk of developing purulentseptic complications and the management of patients. Group 1, control group, (n = 20) included the puerperas, who did not show any signs of inflammatory diseases of the genital tract during pregnancy. Group 2 included patients, who were diagnosed with various forms of vaginal dysbiosis based on the results of bacterioscopic and bacteriological examination of the genital tract. The group was further divided into two subgroups depending on the type of treatment. Subgroup 1 of Group 2 (n = 28) only received standard hygiene care, and subgroup 2 (n = 30) received standard hygiene procedures combined with vaginal irrigation using benzidamine hydrochloride solution (Tantum Rosa) for 3 days in the obstetric hospital.Results. The study resulted in improving postpartum care of high-risk puerperas to prevent purulent-septic complications. Discussion The test results showed that the use of benzidamine hydrochloride (Tantum Rosa) in the postpartum period prevents the purulent-septic complications of puerperium, such as inflammation and disruption of perineal muscle sutures and endometritis, as well as relieves pain and discomfort, and improves the puerperas’ quality of life.Conclusion: Based on the study results, we recommend the use of this drug in the early postpartum period to prevent purulentseptic complications in the high-risk groups