Roughness exponents and grain shapes

In surfaces with grainy features, the local roughness $w$ shows a crossover at a characteristic length $r_c$, with roughness exponent changing from $\alpha_1\approx 1$ to a smaller $\alpha_2$. The grain shape, the choice of $w$ or height-height correlation function (HHCF) $C$, and the procedure to calculate root mean-square averages are shown to have remarkable effects on $\alpha_1$. With grains of pyramidal shape, $\alpha_1$ can be as low as 0.71, which is much lower than the previous prediction 0.85 for rounded grains. The same crossover is observed in the HHCF, but with initial exponent $\chi_1\approx 0.5$ for flat grains, while for some conical grains it may increase to $\chi_1\approx 0.7$. The universality class of the growth process determines the exponents $\alpha_2=\chi_2$ after the crossover, but has no effect on the initial exponents $\alpha_1$ and $\chi_1$, supporting the geometric interpretation of their values. For all grain shapes and different definitions of surface roughness or HHCF, we still observe that the crossover length $r_c$ is an accurate estimate of the grain size. The exponents obtained in several recent experimental works on different materials are explained by those models, with some surface images qualitatively similar to our model films.Comment: 7 pages, 6 figures and 2 table

Finite-size effects in roughness distribution scaling

We study numerically finite-size corrections in scaling relations for roughness distributions of various interface growth models. The most common relation, which considers the average roughness $$as scaling factor, is not obeyed in the steady states of a group of ballistic-like models in 2+1 dimensions, even when very large system sizes are considered. On the other hand, good collapse of the same data is obtained with a scaling relation that involves the root mean square fluctuation of the roughness, which can be explained by finite-size effects on second moments of the scaling functions. We also obtain data collapse with an alternative scaling relation that accounts for the effect of the intrinsic width, which is a constant correction term previously proposed for the scaling of$$. This illustrates how finite-size corrections can be obtained from roughness distributions scaling. However, we discard the usual interpretation that the intrinsic width is a consequence of high surface steps by analyzing data of restricted solid-on-solid models with various maximal height differences between neighboring columns. We also observe that large finite-size corrections in the roughness distributions are usually accompanied by huge corrections in height distributions and average local slopes, as well as in estimates of scaling exponents. The molecular-beam epitaxy model of Das Sarma and Tamborenea in 1+1 dimensions is a case example in which none of the proposed scaling relations works properly, while the other measured quantities do not converge to the expected asymptotic values. Thus, although roughness distributions are clearly better than other quantities to determine the universality class of a growing system, it is not the final solution for this task.Comment: 25 pages, including 9 figures and 1 tabl

Broad Iron Emission from Gravitationally Lensed Quasars Observed by Chandra

Recent work has demonstrated the potential of gravitationally lensed quasars to extend measurements of black hole spin out to high-redshift with the current generation of X-ray observatories. Here we present an analysis of a large sample of 27 lensed quasars in the redshift range 1.0<z<4.5 observed with Chandra, utilizing over 1.6 Ms of total observing time, focusing on the rest-frame iron K emission from these sources. Although the X-ray signal-to-noise (S/N) currently available does not permit the detection of iron emission from the inner accretion disk in individual cases in our sample, we find significant structure in the stacked residuals. In addition to the narrow core, seen almost ubiquitously in local AGN, we find evidence for an additional underlying broad component from the inner accretion disk, with a clear red wing to the emission profile. Based on simulations, we find the detection of this broader component to be significant at greater than the 3-sigma level. This implies that iron emission from the inner disk is relatively common in the population of lensed quasars, and in turn further demonstrates that, with additional observations, this population represents an opportunity to significantly extend the sample of AGN spin measurements out to high-redshift.Comment: 5 pages, 2 figures, accepted for publication in Ap

Optimal protection of stabilised dry live bacteria from bile toxicity in oral dosage forms by bile acid adsorbent resins

We previously found that dried live bacteria of a vaccine strain can be temporarily sensitive to bile acids and suggested that Bile Adsorbing Resins (BAR) can be used in oral vaccine tablets to protect dried bacteria from intestinal bile. Here, we report a quantitative analysis of the ability of BAR to exclude the dye bromophenol blue from penetrating into matrix tablets and also sections of hard capsule shells. Based on this quantitative analysis, we made a fully optimised formulation, comprising 25% w/w of cholestyramine in Vcaps™ HPMC capsules. This gave effectively 100% protection of viability from 4% bile, with 4200-fold more live bacteria recovered from this formulation compared to unprotected dry bacteria. From the image analysis, we found that the filler material or compaction force used had no measurable effect on dye exclusion but did affect the rate of tablet hydration. Increasing the mass fraction of BAR gave more exclusion of dye up to 25% w/w, after which a plateau was reached and no further dye exclusion was seen. More effective dye exclusion was seen with smaller particle sizes (i.e. cholestyramine) and when the BAR was thoroughly dried and disaggregated. Similar results were found when imaging dye penetration into capsule sections or tablets. The predictions of the dye penetration study were tested using capsules filled with dried attenuated Salmonella vaccine plus different BAR types, and the expected protection from bile was found, validating the imaging study. Surprisingly, depending on the capsule shell material, some protection was given by the capsule alone without adding BAR, with Vcaps™ HPMC capsules providing up to 174-fold protection against 1% bile; faster releasing Vcaps Plus™ HPMC capsules and Coni Snap™ gelatin capsules gave less protection

Phase transitions and crossovers in reaction-diffusion models with catalyst deactivation

The activity of catalytic materials is reduced during operation by several mechanisms, one of them being poisoning of catalytic sites by chemisorbed impurities or products. Here we study the effects of poisoning in two reaction-diffusion models in one-dimensional lattices with randomly distributed catalytic sites. Unimolecular and bimolecular single-species reactions are considered, without reactant input during the operation. The models show transitions between a phase with continuous decay of reactant concentration and a phase with asymptotic non-zero reactant concentration and complete poisoning of the catalyst. The transition boundary depends on the initial reactant and catalyst concentrations and on the poisoning probability. The critical system behaves as in the two-species annihilation reaction, with reactant concentration decaying as t^{-1/4} and the catalytic sites playing the role of the second species. In the unimolecular reaction, a significant crossover to the asymptotic scaling is observed even when one of those parameters is 10% far from criticality. Consequently, an effective power-law decay of concentration may persist up to long times and lead to an apparent change in the reaction kinetics. In the bimolecular single-species reaction, the critical scaling is followed by a two-dimensional rapid decay, thus two crossovers are found.Comment: 8 pages, 7 figure