Re-presenting the Paralympics: (contested) philosophies, production practices and the hypervisibility of disability

Studies that have engaged para-sport broadcasting, particularly through a narrative lens, have almost exclusively relied on textual and/or content analysis of the Paralympic Games as the source of cultural critique. We know far less about the decisions taken inside Paralympic broadcasters that have led to such representations. In this study – based on interviews with senior production and promotion staff at the UK’s Paralympic broadcaster, Channel 4 – we provide the first detailed examination of mediated para-sport from this vantage point. We explore the use of promotional devices such as athletes’ backstories – the “Hollywood treatment” – to both hook audiences and serve as a vehicle for achieving its social enterprise mandate to change public attitudes toward disability. In so doing, we reveal myriad tensions that coalesce around representing the Paralympics; with respect to the efforts made to balance the competing goals of key stakeholders and a stated desire to make the Paralympics both a commercial and socially progressive success

Physicochemical attack against solid tumors based on the reversal of direction of entropy flow: an attempt to introduce thermodynamics in anticancer therapy

BACKGROUND: There are many differences between healthy tissue and growing tumor tissue, including metabolic, structural and thermodynamic differences. Both structural and thermodynamic differences can be used to follow the entropy differences in cancerous and normal tissue. Entropy production is a bilinear form of the rates of irreversible processes and the corresponding "generalized forces". Entropy production due to various dissipation mechanisms based on temperature differences, chemical potential gradient, chemical affinity, viscous stress and exerted force is a promising tool for calculations relating to potential targets for tumor isolation and demarcation. METHODS: The relative importance of five forms of entropy production was assessed through mathematical estimation. Using our mathematical model we demonstrated that the rate of entropy production by a cancerous cell is always higher than that of a healthy cell apart from the case of the application of external energy. Different rates of entropy production by two kinds of cells influence the direction of entropy flow between the cells. Entropy flow from a cancerous cell to a healthy cell transfers information regarding the cancerous cell and propagates its invasive action to the healthy tissues. To change the direction of entropy flow, in addition to designing certain biochemical pathways to reduce the rate of entropy production by cancerous cells, we suggest supplying external energy to the tumor area, changing the relative rate of entropy production by the two kinds of cells and leading to a higher entropy accumulation in the surrounding normal cells than in the tumorous cells. CONCLUSION: Through the use of mathematical models it was quantitatively demonstrated that when no external force field is applied, the rate of entropy production of cancerous cells is always higher than that of healthy cells. However, when the external energy of square wave electric pulses is applied to tissues, the rate of entropy production of normal cells may exceed that of cancerous cells. Consequently, the application of external energy to the body can reverse the direction of the entropy current. The harmful effect brought about by the entropy flow from cancerous to healthy tissue can be blocked by the reversed direction of entropy current from the irradiated normal tissue around the tumor

Will You Value Me and Do I Value You? The Effect of Phenotypic Racial Stereotypicality on Organizational Evaluations

This paper investigates whether within-group differences in phenotypic racial stereotypicality (i.e., extent to which individuals possess physical features typical of their racial group) of ingroup members serve as social identity contingency cues for Blacks evaluating organizations. It is hypothesized that Blacks draw information about whether their social identity would be valued based on the represented phenotypic racial stereotypicality of Black organization members. Participants viewed organizations that included high phenotypically stereotypic (HPS) Black (e.g., darker skin tones, broader facial features), low phenotypically stereotypic (LPS) Black, or only White employees. Results confirmed that Black, but not White, evaluators reported more diversity, salary, desire to work, and social identity-related trust toward the HPS, compared to LPS and White, organizations. The relationships between phenotypic racial stereotypicality condition on organizational attractiveness and diversity perceptions were mediated by identity-related trust. Results suggest considering diversity at both the group level and within group level to achieve broader benefits

How Social Networking Use and Beliefs About Inequality Affect Engagement With Racial Justice Movements

Social media is an increasingly prominent platform for sharing information about current social issues. In the recent case of the fatal shooting of unarmed Black teenager Michael Brown by a White police officer in 2014, social media was a major influence in the mobilization of social movements including Black Lives Matter (BLM). This study explores the relationship between the use of social networking (SN) websites for policing-related content, beliefs about inequality, and engagement in racial justice movements. Students at a large university (N = 539) completed an online survey that measured social attitudes focused on policing, inequality, and social movements. Multiple linear and logistic regression analyses tested the effects of individuals’ awareness of oppression and privilege, and SN site use on both (1) support and (2) participation in racial justice movements. Results found that SN website use for policing information was positively related to both support and participation in protests and BLM. Further, in predicting support for protests, this relationship was stronger for individuals who were higher in awareness of oppression and privilege, compared to those who were lower. This study highlights the importance of understanding how social beliefs interact with SN site use to impact social justice engagement

How Social Networking Use and Beliefs About Inequality Affect Engagement With Racial Justice Movements

Social media is an increasingly prominent platform for sharing information about current social issues. In the recent case of the fatal shooting of unarmed Black teenager Michael Brown by a White police officer in 2014, social media was a major influence in the mobilization of social movements including Black Lives Matter (BLM). This study explores the relationship between the use of social networking (SN) websites for policing-related content, beliefs about inequality, and engagement in racial justice movements. Students at a large university (N = 539) completed an online survey that measured social attitudes focused on policing, inequality, and social movements. Multiple linear and logistic regression analyses tested the effects of individuals’ awareness of oppression and privilege, and SN site use on both (1) support and (2) participation in racial justice movements. Results found that SN website use for policing information was positively related to both support and participation in protests and BLM. Further, in predicting support for protests, this relationship was stronger for individuals who were higher in awareness of oppression and privilege, compared to those who were lower. This study highlights the importance of understanding how social beliefs interact with SN site use to impact social justice engagement

Prospective multicentre randomised trial comparing the efficacy and safety of single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) versus Roux-en-Y gastric bypass (RYGB): SADISLEEVE study protocol

International audienceINTRODUCTION: Despite the non-negligible weight loss failure rate at midterm, Roux-en-Y gastric bypass (RYGB) remains the reference procedure in the treatment of morbid obesity with metabolic comorbidities. A recently emerged procedure, the single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S), could be more effective on weight loss with similar morbidity and lower weight loss failure rate than RYGB. We propose the first randomised, open, multicentre superiority trial comparing the SADI-S to RYGB (SADISLEEVE). METHODS AND ANALYSIS: The main objective is to demonstrate the superiority at 2 years after surgery of the SADI-S compared with RYGB in term of excess weight loss percentage. The secondary objectives are the evaluation of nutritional status, metabolic outcomes, overall complication rates and quality of life, within 2 years after surgery. Key inclusion criteria are obese patients with body mass index (BMI) ≥40 kg/m(2) or ≥35 kg/m(2) with at least one comorbid condition and candidate to a first bariatric procedure or after failure of sleeve gastrectomy. Patients randomised by minimisation in two arms, based on centre, surgery as a revisional procedure, presence of type 2 diabetes and BMI \textgreater50 kg/m(2) will be included over 2 years.A sample size of 166 patients in each group will have a power of 90% to detect a probability of 0.603 that excess weight loss in the RYGB arm is less than excess weight loss in the SADI-S arm with a 5% two-sided significance level. With a drop-out rate of 10%, it will be necessary to include 183 patients per group. ETHICS AND DISSEMINATION: The study was approved by Institutional Review Board of Centre Hospitalier Universitaire Morvan (CPP1089-HPS1). Study was also approved by the French national agency for drug safety (2018061500148). Results will be reported in peer-reviewed scientific journals. TRIAL REGISTRATION NUMBER: NCT03610256

Oregano Oil and Its Principal Component, Carvacrol, Inhibit HIV-1 Fusion into Target Cells

Oregano essential oil has long been known for its health-promoting benefits. Here, we report its activity against viral replication. Oregano oil was found to specifically inhibit lentiviruses, such as human and simian immunodeficiency viruses (HIV and SIV), irrespective of virus tropism, but not hepatitis C virus, adenovirus 5 (ADV5), Zika virus, and influenza (H1N1) virus. Oregano oil's most abundant components, carvacrol and its isomer, thymol, were shown to block virus-target cell fusion while not perturbing other stages of the virus life cycle. We detected changes in virus particle density, suggesting that cholesterol depletion from the HIV-1 envelope membrane reduces virus entry. Furthermore, infection was rescued by adding exogenous cholesterol. The evolution of viral resistance to carvacrol supported this mechanism of action with the identification of mutations in the viral gp41 fusion protein that counteracted cholesterol depletion. In addition, resistance to carvacrol emerged later than typically observed for other clinically used drugs, strengthening its antiviral potential. Structure-activity relationship studies revealed key motifs of carvacrol and thymol required for HIV neutralization and identified previously unknown active analogs. Carvacrol was also shown to additively cooperate with antiretroviral therapy. In sum, oregano oil and improved carvacrol and thymol analogs could be considered to supplement current HIV therapeutics. Oregano essential oil has multiple benefits in traditional medicine, cosmetics, and food industries. Carvacrol and its analog, thymol, are well-described components of oregano oil. Here, we show that these compounds inhibit HIV-target cell fusion independently of viral tropism. Our results suggest that carvacrol and thymol alter the cholesterol content of the viral membrane, blocking HIV-1 entry into the target cell. Resistance to carvacrol has selected for viruses with mutations in the viral envelope glycoprotein, gp41. This protein is known for its interaction with cholesterol present in membrane lipid rafts. Together, these results demonstrate the potential of therapies targeting the viral envelope membrane, and oregano oil is a safe supplement to antiretrovirals, potentially delaying disease progression and resistance development