Strong Forms of b-Continuous Multifunctions

In this paper we have introduced strong forms of b-continuous multifunctions namely b#-multicontinuity and *b-multicontinuity and studied their properties and characterizations. Also investigate the relationship with other type of functions with suitable examples

Rifampicin-induced renal toxicity during retreatment of patients with pulmonary tuberculosis

Rifampicin is a crucial component of treatment regimens for tuberculosis and has been in use since the early 1970’s. It is usually considered safe. Rarely life-threatening complications like acute renal failure or acute thrombocytopaenia may manifest during treatment with rifampicin. In our experience at the Tuberculosis Research Centre of treating more than 8000 pulmonary and extrapulmonary tuberculosis patients with rifampicin-containing regimens over the last 30 years, we are reporting 3 cases of probably rifampicininduced acute renal failure. Despite extreme therapeutic safety of this drug the clinician must be aware of this rare complication, which if detected early is completely reversible

THREE-DIMENSIONAL QUANTITATIVE STRUCTURE–ACTIVITY RELATIONSHIPS MODELING STUDIES OF PHYTOCHEMICALS FROM BRASSICACEAE AS POTENT INHIBITORS AGAINST TUMOR INFLAMMATION

Objective: The aim of this study was to develop a three-dimensional quantitative structure–activity relationships (3D-QSARs) model for studying theinteraction of different phytochemicals with nuclear factor kappa B (NF-ĸB) inducing kinase, a major regulator in tumor inflammation.Methods: Different phytochemicals (ligands) from Brassicaceae were selected and tested for Lipinski's rule of five and further analyzed using interaction studies (docking) to identify the binding site in the target protein. Ligands with best fit were made to pass through ADMET filter, and the nontoxic ligands were selected based on the pIC50 values.Results: The 3D-QSARs of the ligands were designed using comparative molecular field analysis, and glucoraphanin was found to be stable and fit after subjecting for molecular dynamics simulation with annealing studies.Conclusion: Thus, the model may be prospectively used in drug design to find possible inhibitors of NF-ĸB, which plays a key prominent role in cancer inflammation.Keywords: Three-dimensional quantitative structure–activity relationships, Brassica oleracea, Simulation, Annealing, Nuclear factor kappa B kinase

Three-body decay of 6^{6}Be

Three-body correlations for the ground-state decay of the lightest two-proton emitter $^{6}$Be are studied both theoretically and experimentally. Theoretical studies are performed in a three-body hyperspherical-harmonics cluster model. In the experimental studies, the ground state of $^{6}$Be was formed following the $\alpha$ decay of a $^{10}$C beam inelastically excited through interactions with Be and C targets. Excellent agreement between theory and experiment is obtained demonstrating the existence of complicated correlation patterns which can elucidate the structure of $^{6}$Be and, possibly, of the A=6 isobar.Comment: 17 pages, 21 figures, 5 table

Astrophysical S factor for the radiative capture 12N(p,gamma)13O determined from the 14N(12N,13O)13C proton transfer reaction

The cross section of the radiative proton capture reaction on the drip line nucleus 12N was investigated using the Asymptotic Normalization Coefficient (ANC) method. We have used the 14N(12N,13O)13C proton transfer reaction at 12 MeV/nucleon to extract the ANC for 13O -> 12N + p and calculate from it the direct component of the astrophysical S factor of the 12N(p,gamma)13O reaction. The optical potentials used and the DWBA analysis of the proton transfer reaction are discussed. For the entrance channel, the optical potential was inferred from an elastic scattering measurement carried out at the same time with the transfer measurement. From the transfer, we determined the square of the ANC, C^2(13Og.s.) = 2.53 +/- 0.30 fm-1, and hence a value of 0.33(4) keVb was obtained for the direct astrophysical S factor at zero energy. Constructive interference at low energies between the direct and resonant captures leads to an enhancement of Stotal(0) = 0.42(5) keVb. The 12N(p,gamma)13O reaction was investigated in relation to the evolution of hydrogen-rich massive Population III stars, for the role that it may play in the hot pp-chain nuclear burning processes, possibly occurring in such objects.Comment: 15 pages, 10 figures, 3 tables submitted to Phys. Rev.

Measurement of the π−\pi^- decay width of Λ5^5_\LambdaHe

We have precisely measured $\Lambda \to p\pi^-$ decay width of \5LHe and demonstrated significantly larger $\alpha$ -$\Lambda$ overlap than expected from the central repulsion $\alpha$-$\Lambda$ potential, which is derived from YNG \Lambda$-nucleon interaction.Comment: 4 pages, 3 figure

A case report on methotrexate induced pancytopenia

Systemic lupus erythematosus (SLE) is a non-specific systemic inflammatory disease that affects various organ systems in the body leading to a wide spectrum of clinical presentations. The management of SLE includes therapy with immunosuppressant agents who have a narrow safety range and a wide adverse effect profile. Methotrexate discussed in this case report is one of such drugs whose short term and long term usage has been associated with various adverse events that affect the individuals quality of life. So, it is always advisable to take prophylactic measures and to provide patient education to detect and prevent adverse events at the earliest

Proton asymmetry in non-mesonic weak decay of light hypernuclei

We have obtained the decay asymmetry parameters in non-mesonic weak decay of polarized Lambda-hypernuclei by measuring the proton asymmetry. The polarized Lambda-hypernuclei, 5_Lambda-He, 12_Lambda-C, and 11_Lambda-B, were produced in high statistics via the (pi^+,k^+) reaction at 1.05 GeV/c in the forward angles. Preliminary analysis shows that the decay asymmetry parameters are very small for these s-shell and p-shell hypernuclei.Comment: 4pages, 4figures, International Conference on Hypernuclear and Strange Particle Physics (HYP2003