The parallax distorsion via a weak microlensing effect

Parallax measurements allow distances to celestial objects to be determined. Coupled with measurement of their position on the celestial sphere, it gives a full three-dimensional picture of the location of the objects relative to the observer. The distortion of the parallax value of a remote source affected by a weak microlensing is considered. This means that the weak microlensing leads to distortion of the distance scale. It is shown that the distortions to appear may change strongly the parallax values in case they amount to several microseconds of arc. In particular, at this accuracy many measured values of the parallaxes must be negative.Comment: 34 LaTeX pages, 12 PostScript figure (epsfig.sty

Microarcsecond instability of the celestial reference frame

The fluctuation of the angular positions of reference extragalactic radio and optical sources under the influence of the irregular gravitational field of visible Galactic stars is considered. It is shown that these angular fluctuations range from a few up to hundreds of microarcseconds. This leads to a small rotation of the celestial reference frame. The nondiagonal coefficients of the rotation matrix are of the order of a microarcsecond. The temporal variation of these coefficients due to the proper motion of the foreground stars is of the order of one microsecond per 20 years. Therefore, the celestial reference frame can be considered inertial and homogeneous only to microarcsecond accuracy. Astrometric catalogues with microarcsecond accuracy will be unstable, and must be reestablished every 20 years.Comment: 5 pages, 2 figures, accepted to MNRA

Synthesis and properties of nitrogen-containing 1,2,3-thiadiazoles

Одно из наиболее перспективных направлений в развитии химии гетероциклических соединений представляет собой синтез и изучение химических свойств и биологической активности моно- и бициклических систем на основе 1,2,3-тиадиазолов. Целью работы являлось разработка методов синтеза 1,2,3-тиадиазолов, содержащих функциональные группы, способные вызвать перегруппировку, трансформации и циклизацию в другие гетероциклы. Такими фрагментами являются азотсодержащие группы в 4 и 5 положении цикла. Изучение перегруппировок и трансформаций синтезированных 1,2,3-тиадиазолов. Синтез на основе метода перегруппировок и трансформаций широкого ряда производных 1,2,3-тиадиазола, 1,2,3-триазолола и ансамблей гетероциклов.One of the most interesting research direction in heterocyclic chemistry is the synthesis and study of the chemical properties and biological activity of mono- and bicyclic systems based on 1,2,3- thiadiazoles. The purpose of the project was development of methods for the synthesis of 1,2,3- thiadiazoles containing functional groups which may cause rearrangement and cyclization to transform other heterocycles . It may be fragments containing nitrogen groups in 4 and 5 position of thiadiazole’s cycle. The study of the rearrangements and transformations of the synthesized 1,2,3- thiadiazoles . Synthesis based on the transformation method and the rearrangement of a wide range of 1,2,3- thiadiazole derivatives, 1,2,3- triazolola, heterocycle ensembles.Программа развития УрФУ на 2013 год (п.1.2.2.3

БИБЛИОТЕРАПИЯ КАК ЭФФЕКТИВНЫЙ МЕТОД РАБОТЫ С ДЕПРЕССИВНЫМИ СОСТОЯНИЯМИ

The article reveals the problem of depressive states of young students and its relevance today in the work of the psychological and pedagogical service of the university. Bibliotherapy is presented as one of the effective art-therapeutic methods in work with depressive states. Two directions of bibliotherapy on the degree of client involvement in the psychothe­rapeutic process are presented. The diagnostic and therapeutic potential of bibliotherapy is described. An attempt has been made to describe the use of bibliotherapy in working with depressive states of modern students.В статье раскрыта проблема депрессивных состояний учащейся молодежи и ее актуальность на сегодняшний день в работе психолого-педагогической службы вуза. Библиотерапия представлена, как один из эффективных арт-терапевтических методов в работе с депрессивными состояниями. Представлено два направления библиотерапии по степени включенности клиента в психотерапевтический процесс. Описан диагностический и терапевтический потенциал библиотерапии. Предпринята попытка описания использования библиотерапии в работе с деприссивными состояниями современной учащейся молодежи

Medico-social rationale for adaptation of regional drug supply systems to personalized pharmaceutical care for persons of different ages

In this study, we identified indicators of the state of personalized pharmaceutical care for target population groups at the regional level, in a model region, with the aim to develop a differentiated approach to such care. The rationale for the choice of Moscow Region as a model region is based on its specific socioeconomic indicators and a comparison of these with respective average Russian values. A need was shown to modernize patient-oriented pharmaceutical care, especially for certain population groups, such as children, women of working age (mothers), and the elderl

Large Oligomeric Complex Structures Can Be Computationally Assembled by Efficiently Combining Docked Interfaces

Macromolecular oligomeric assemblies are involved in many biochemical processes of living organisms. The benefits of such assemblies in crowded cellular environments include increased reaction rates, efficient feedback regulation, cooperativity and protective functions. However, an atom‐level structural determination of large assemblies is challenging due to the size of the complex and the difference in binding affinities of the involved proteins. In this study, we propose a novel combinatorial greedy algorithm for assembling large oligomeric complexes from information on the approximate position of interaction interfaces of pairs of monomers in the complex. Prior information on complex symmetry is not required but rather the symmetry is inferred during assembly. We implement an efficient geometric score, the transformation match score, that bypasses the model ranking problems of state‐of‐the‐art scoring functions by scoring the similarity between the inferred dimers of the same monomer simultaneously with different binding partners in a (sub)complex with a set of pregenerated docking poses. We compiled a diverse benchmark set of 308 homo and heteromeric complexes containing 6 to 60 monomers. To explore the applicability of the method, we considered 48 sets of parameters and selected those three sets of parameters, for which the algorithm can correctly reconstruct the maximum number, namely 252 complexes (81.8%) in, at least one of the respective three runs. The crossvalidation coverage, that is, the mean fraction of correctly reconstructed benchmark complexes during crossvalidation, was 78.1%, which demonstrates the ability of the presented method to correctly reconstruct topology of a large variety of biological complexes. Proteins 2015; 83:1887–1899. © 2015 The Authors. Proteins: Structure, Function, and Bioinformatics Published by Wiley Periodicals, Inc

Development of A. Solani β-tubulin Models and Comparison of Docking Results for Benzo[d]azoles Derivatives as Potential Antifungal Agents

Received: 30.11.23. Revised: 16.01.24. Accepted: 19.01.24. Available online: 29.01.24.A convenient approach was found to generate isomers of organic compounds using the KNIME and DataWarrior programs.A convenient approach was found to generate isomers of organic compounds using the KNIME and DataWarrior programs.The use of two homologous β-tubulin models in virtual screening results in the similar hit selection.An approach to developing a docking protocol using free software such as KNIME, DataWarrior, AutoDock Vina, AutoDockTools, OpenBabel and the SWISS-MODEL service was described. In particular, the process of generating possible isomeric structures using KNIME chemoinformatics libraries is described. A library of benzo[d]azoles containing 145 compounds with homologous models of Alternaria solani β-tubulin obtained in two ways: using the commercial Prime program and the free SWISS-MODEL service, the comparison of results was shown. Despite the less preorganization of the binding cavity of the homologous model obtained using SWISS-MODEL, the correlation of the results between the two methods were observed. The correlation coefficients were as follows: Pearson was 0.65, Spearman was 0.62. According to the docking results, 99% of the studied 2-aminobenzo[d]azoles derivatives showed a docking score of no more than –7, which indicates that these compounds are promising for studying the fungicidal activity, in particular against A. solani. Without taking into account pharmacokinetic characteristics, benzo[d]imidazole derivatives containing a sulfanilamidine substituent at the 2-amino group and thioacetyl derivatives of 2-aminobenzo[d]imidazole are of particular interest in the search for new antitubulin fungicides.This research was supported by the Russian Science Foundation and Government of Sverdlovsk region, Joint Grant No 22-26-20124, https://rscf.ru/en/project/22-26-20124

Modeling the Antitubulin Activity of Benzimidazol-2-yl Carbamates: Mini-review

The biological activity of 5-benzimidazol-2-yl carbamate derivatives is associated with their ability to form a complex with /3-tubulin and, consequently, disrupt the process of assembly of microtubules of the cytoskeleton of cells. Over the past 10 years, the understanding of the binding of 5-benzimidazol-2-yl carbamate derivatives to the /3-tubulin subunit has increased significantly, mainly due to the published crystal structures of their ligand-receptor complexes. However, some details of this process could be predicted based on the results of molecular modeling before the publication of the corresponding crystal data. This mini-review summarizes the results of such works. © 2021 Author(s).This research was supported by the Russian Foundation for Basic Research (grant No. 18-316-20018)