(2-Hydroxy­ethyl)(prop­yl)aza­nium 2-[(2-carboxy­phen­yl)disulfan­yl]benzoate monohydrate

With the exception of the terminal hydr­oxy group [N—C—C—O = 53.8 (5)°], the cation of the title salt hydrate, C5H14NO+·C14H9O4S2 −.H2O, is a straight chain. A twisted conformation is found for the anion [C—S—S—C = −87.44 (16)°]. In the crystal, the anions self-assemble into a helical supra­molecular chain via charge-assisted O—H⋯Oc hydrogen bonds. These chains are connected into a three-dimensional network via N—H⋯Oc, N—H⋯Ow, Oh—H⋯Ocb, and Ow—H⋯Oc hydrogen-bonding inter­actions (c = carboxyl­ate, w = water, h = hydr­oxy and cb = carbon­yl)

Bis[eth­yl(2-hydroxy­ethyl)aza­nium] 2,2′-disulfanediyldibenzoate

The asymmetric unit of the title salt, 2C4H12NO+·C14H8O4S2 2−, contains an eth­yl(2-hydr­oxy)aminium cation and half a 2,2′-disulfanediyldibenzoate anion, with the latter disposed about a twofold axis. The cation is a straight chain with the exception of the terminal hydr­oxy group [the N—C—C—O torsion angle is 66.5 (2)°]. A twisted conformation is found for the anion [the C—S—S—C torsion angle is 91.51 (9)° and the dihedral angle between the rings is 81.01 (4)°]. A supra­molecular chain with base vector [101] and a tubular topology is formed in the crystal structure mediated by charge-assisted O—H⋯O− and N+—H⋯O− hydrogen bonding

2,2′-Imino­diethanaminium 2,2′-(disulfanyldi­yl)dibenzoate dihydrate

In the title hydrated salt, C4H15N3 2+·C14H8O4S2 −·2H2O, the dication (with both terminal –NH2 groups protonated) adopts a U-shaped conformation, the Namine—C—C—Naza­nium torsion angles being 57.9 (6) and 60.3 (6)°. The dianion is twisted: the central C—S—S—C torsion angle is 81.3 (2)° and the dihedral angle between the benzene rings is 85.4 (3)°. In the crystal, a chain in the a-axis direction mediated by water–carboxyl­ate O—H⋯O hydrogen bonds through a sequence of alternating 12-membered {⋯OCO⋯HOH}2 and eight-membered {⋯O⋯HOH}2 synthons occurs, which involves only one of the carboxyl­ate residues. The second carboxyl­ate residue participates in N—H⋯O hydrogen bonding, generating a three-dimensional network, along with aza­nium–water N—H⋯O hydrogen bonds

Bis[N-2-hydroxyethyl,N-methyldithiocarbamato-κ2 S,S)'-4-{[(pyridin-4-ylmethylidene)hydrazinylidene}methyl]pyridine-κN 1)zinc(II): crystal structure and Hirshfeld surface analysis

In the title compound, [Zn(C4H8NOS2)2(C12H10N4)], the ZnII atom exists within a NS4 donor set defined by two chelating dithiocarbamate ligands and a pyridyl-N atom derived from a terminally bound 4-pyridinealdazine ligand. The distorted coordination geometry tends towards square-pyramidal with the pyridyl-N atom occupying the apical position. In the crystal, hydroxyl-O—H...O(hydroxyl) and hydroxyl-O—H...N(pyridyl) hydrogen-bonding give rise to a supramolecular double-chain along [1-10]; methyl-C—H...π(chelate ring) interactions help to consolidate the chain. The chains are connected into a three-dimensional architecture via pyridyl-C—H...O(hydroxyl) interactions. In addition to the contacts mentioned above, the Hirshfeld surface analysis points to the significance of relatively weak π–π interactions between pyridyl rings [inter-centroid distance = 3.901 (3) Å]

3-[3-(trifluoromethyl)phenyliminomethyl]benzene-1,2-diol

The crystal packing of the essentially planar molecules of the title compound, C14H10F3NO2, is stabilized by O - (HO)-O-... hydrogen bonds and possible C - (HO)-O-... and C - (HF)-F-... interactions

N-formyl-N '-(2-oxidobenzylidene) hydrazine-kappa(3) O, N, O '] diphenyltin(IV)

The title compound, [Sn(C6H5)(2)(C8H6N2O2)], features a five-coordinate C2NO2 coordination geometry for Sn that is intermediate between trigonal-bipyramidal and square-pyramidal

Bis[N-(2-hy­droxy­eth­yl)-N-propyl­dithio­carbamato-κ2 S,S′]bis­(4-{[(pyridin-4-yl­methyl­idene)hydrazinyl­idene]meth­yl}pyridine-κN 1)cadmium

The complete mol­ecule of the title compound, [Cd(C6H12NOS2)2(C12H10N4)2], is generated by crystallographic inversion symmetry. The distorted octa­hedral trans-N2S4 donor set for the Cd2+ ion is defined by two symmetrically S,S′-chelating dithio­carbamate anions and two pyridine N atoms derived from two monodentate 4-pyridine­aldazine (or 4-{[(pyridin-4-yl­methyl­idene)hydrazinyl­idene}meth­yl]pyridine) mol­ecules [dihedral angle between the aromatic rings = 17.33 (8)°]. In the crystal, mol­ecules are connected into a supra­molecular chain via O—H⋯N hydrogen bonds involving the 4-pyridine­aldazine N atoms not involved in coordination to cadmium. Weak C—H⋯O and C—H⋯N links consolidate the packing

Ethyl [1-(4-bromo­phen­yl)-1-hydr­oxy-3-oxobut­yl](phen­yl)phosphinate monohydrate1

In the title hydrate, C18H20BrO4P·H2O, a staggered conformation is found when the organic mol­ecule is viewed down the central P—C bond, with the oxo and hydroxyl groups being diagonally opposite; each of the central P and C atoms has an S-configuration. The crystal structure features supra­molecular double chains along the b axis mediated by Ohydrox­yl–H⋯Ooxo, Owater–H⋯Ooxo, and Owater–H⋯Owater hydrogen bonds

Bis(propan-2-yl) [(2S,3S)-2-hydr­oxy-3-nitro­butan-2-yl]phospho­nate

In the title compound, C10H22NO6P, a staggered conformation is found when the mol­ecule is viewed down the central P—C bond, with the oxo and hydr­oxy groups gauche to each other. The crystal structure features supra­molecular chains of helical topology propagating along the b axis, mediated by O—H⋯O hydrogen bonds

Viral-E1 and Viral-E2 Proteins Support Replication of Homologous and Heterologous Papillomaviral Origins

We have shown that E1 and E2 proteins of human papillomavirus type 11 (HPV-11) were essential to support the replication of the homologous viral origin (ori) in a transient replication assay, similar to reports on bovine papillomavirus type 1 (BPV-1). Unexpectedly, matched or even mixed combinations of E1 and E2 proteins from HPV-11 or BPV-1 replicated either ori in human, monkey, and rodent cell lines of epithelial or fibroblastic lineage, albeit with varied efficiencies. Either set of viral proteins was also able to initiate replication of ori-containing plasmids from many other human and animal papillomaviruses. Thus the interactions among the cis elements and trans factors of papillomaviruses are more conserved than expected from the other members of the papovavirus family, simian virus 40 and polyomavirus, for which large tumor antigen does not replicate a heterologous ori in either permissive or nonpermissive cells. We infer that the stringent species and tissue specificities observed for papillomaviruses in vivo are not entirely due to direct restrictions on viral DNA replication. Rather, transcriptional control of viral gene expression must play a dominant role