129 research outputs found
Many-body Landau-Zener dynamics in coupled 1D Bose liquids
The Landau-Zener model of a quantum mechanical two-level system driven with a
linearly time dependent detuning has served over decades as a textbook paradigm
of quantum dynamics. In their seminal work [L. D. Landau, Physik. Z. Sowjet. 2,
46 (1932); C. Zener, Proc. Royal Soc. London 137, 696 (1932)], Landau and Zener
derived a non-perturbative prediction for the transition probability between
two states, which often serves as a reference point for the analysis of more
complex systems. A particularly intriguing question is whether that framework
can be extended to describe many-body quantum dynamics. Here we report an
experimental and theoretical study of a system of ultracold atoms, offering a
direct many-body generalization of the Landau-Zener problem. In a system of
pairwise tunnel-coupled 1D Bose liquids we show how tuning the correlations of
the 1D gases, the tunnel coupling between the tubes and the inter-tube
interactions strongly modify the original Landau-Zener picture. The results are
explained using a mean-field description of the inter-tube condensate
wave-function, coupled to the low-energy phonons of the 1D Bose liquid.Comment: 13 pages, 10 figures
Optics with an Atom Laser Beam
We report on the atom optical manipulation of an atom laser beam. Reflection,
focusing and its storage in a resonator are demonstrated. Precise and versatile
mechanical control over an atom laser beam propagating in an inhomogeneous
magnetic field is achieved by optically inducing spin-flips between atomic
ground states with different magnetic moment. The magnetic force acting on the
atoms can thereby be effectively switched on and off. The surface of the atom
optical element is determined by the resonance condition for the spin-flip in
the inhomogeneous magnetic field. A mirror reflectivity of more than 98% is
measured
Observation of mesoscopic crystalline structures in a two-dimensional Rydberg gas
The ability to control and tune interactions in ultracold atomic gases has
paved the way towards the realization of new phases of matter. Whereas
experiments have so far achieved a high degree of control over short-ranged
interactions, the realization of long-range interactions would open up a whole
new realm of many-body physics and has become a central focus of research.
Rydberg atoms are very well-suited to achieve this goal, as the van der Waals
forces between them are many orders of magnitude larger than for ground state
atoms. Consequently, the mere laser excitation of ultracold gases can cause
strongly correlated many-body states to emerge directly when atoms are
transferred to Rydberg states. A key example are quantum crystals, composed of
coherent superpositions of different spatially ordered configurations of
collective excitations. Here we report on the direct measurement of strong
correlations in a laser excited two-dimensional atomic Mott insulator using
high-resolution, in-situ Rydberg atom imaging. The observations reveal the
emergence of spatially ordered excitation patterns in the high-density
components of the prepared many-body state. They have random orientation, but
well defined geometry, forming mesoscopic crystals of collective excitations
delocalised throughout the gas. Our experiment demonstrates the potential of
Rydberg gases to realise exotic phases of matter, thereby laying the basis for
quantum simulations of long-range interacting quantum magnets.Comment: 10 pages, 7 figure
Precision measurement of spin-dependent interaction strengths for spin-1 and spin-2 87Rb atoms
We report on precision measurements of spin-dependent interaction-strengths
in the 87Rb spin-1 and spin-2 hyperfine ground states. Our method is based on
the recent observation of coherence in the collisionally driven spin-dynamics
of ultracold atom pairs trapped in optical lattices. Analysis of the Rabi-type
oscillations between two spin states of an atom pair allows a direct
determination of the coupling parameters in the interaction hamiltonian. We
deduce differences in scattering lengths from our data that can directly be
compared to theoretical predictions in order to test interatomic potentials.
Our measurements agree with the predictions within 20%. The knowledge of these
coupling parameters allows one to determine the nature of the magnetic ground
state. Our data imply a ferromagnetic ground state for 87Rb in the f=1
manifold, in agreement with earlier experiments performed without the optical
lattice. For 87Rb in the f=2 manifold the data points towards an
antiferromagnetic ground state, however our error bars do not exclude a
possible cyclic phase.Comment: 11 pages, 5 figure
Many-Body Physics with Ultracold Gases
This article reviews recent experimental and theoretical progress on
many-body phenomena in dilute, ultracold gases. Its focus are effects beyond
standard weak-coupling descriptions, like the Mott-Hubbard-transition in
optical lattices, strongly interacting gases in one and two dimensions or
lowest Landau level physics in quasi two-dimensional gases in fast rotation.
Strong correlations in fermionic gases are discussed in optical lattices or
near Feshbach resonances in the BCS-BEC crossover.Comment: revised version, accepted for publication in Rev. Mod. Phy
Different paths to the modern state in Europe: the interaction between domestic political economy and interstate competition
Theoretical work on state formation and capacity has focused mostly on early modern Europe and on the experience of western European states during this period. While a number of European states monopolized domestic tax collection and achieved gains in state capacity during the early modern era, for others revenues stagnated or even declined, and these variations motivated alternative hypotheses for determinants of fiscal and state capacity. In this study we test the basic hypotheses in the existing literature making use of the large date set we have compiled for all of the leading states across the continent. We find strong empirical support for two prevailing threads in the literature, arguing respectively that interstate wars and changes in economic structure towards an urbanized economy had positive fiscal impact. Regarding the main point of contention in the theoretical literature, whether it was representative or authoritarian political regimes that facilitated the gains in fiscal capacity, we do not find conclusive evidence that one performed better than the other. Instead, the empirical evidence we have gathered lends supports to the hypothesis that when under pressure of war, the fiscal performance of representative regimes was better in the more urbanized-commercial economies and the fiscal performance of authoritarian regimes was better in rural-agrarian economie
Clustering of classical swine fever virus isolates by codon pair bias
<p>Abstract</p> <p>Background</p> <p>The genetic code consists of non-random usage of synonymous codons for the same amino acids, termed codon bias or codon usage. Codon juxtaposition is also non-random, referred to as codon context bias or codon pair bias. The codon and codon pair bias vary among different organisms, as well as with viruses. Reasons for these differences are not completely understood. For classical swine fever virus (CSFV), it was suggested that the synonymous codon usage does not significantly influence virulence, but the relationship between variations in codon pair usage and CSFV virulence is unknown. Virulence can be related to the fitness of a virus: Differences in codon pair usage influence genome translation efficiency, which may in turn relate to the fitness of a virus. Accordingly, the potential of the codon pair bias for clustering CSFV isolates into classes of different virulence was investigated.</p> <p>Results</p> <p>The complete genomic sequences encoding the viral polyprotein of 52 different CSFV isolates were analyzed. This included 49 sequences from the GenBank database (NCBI) and three newly sequenced genomes. The codon usage did not differ among isolates of different virulence or genotype. In contrast, a clustering of isolates based on their codon pair bias was observed, clearly discriminating highly virulent isolates and vaccine strains on one side from moderately virulent strains on the other side. However, phylogenetic trees based on the codon pair bias and on the primary nucleotide sequence resulted in a very similar genotype distribution.</p> <p>Conclusion</p> <p>Clustering of CSFV genomes based on their codon pair bias correlate with the genotype rather than with the virulence of the isolates.</p
Esophageal and Gastric Malignancies After Bariatric Surgery: a Retrospective Global Study
Background: Bariatric surgery can influence the presentation, diagnosis, and management of gastrointestinal cancers. Esophagogastric (EG) malignancies in patients who have had a prior bariatric procedure have not been fully characterized.
Objective: To characterize EG malignancies after bariatric procedures.
Setting: University Hospital, United Kingdom.
Methods: We performed a retrospective, multicenter observational study of patients with EG malignancies after bariatric surgery to characterize this condition.
Results: This study includes 170 patients from 75 centers in 25 countries who underwent bariatric procedures between 1985 and 2020. At the time of the bariatric procedure, the mean age was 50.2 ± 10 years, and the mean weight 128.8 ± 28.9 kg. Women composed 57.3% (n = 98) of the population. Most (n = 64) patients underwent a Roux-en-Y gastric bypass (RYGB) followed by adjustable gastric band (AGB; n = 46) and sleeve gastrectomy (SG; n = 43). Time to cancer diagnosis after bariatric surgery was 9.5 ± 7.4 years, and mean weight at diagnosis was 87.4 ± 21.9 kg. The time lag was 5.9 ± 4.1 years after SG compared to 9.4 ± 7.1 years after RYGB and 10.5 ± 5.7 years after AGB. One third of patients presented with metastatic disease. The majority of tumors were adenocarcinoma (82.9%). Approximately 1 in 5 patients underwent palliative treatment from the outset. Time from diagnosis to mortality was under 1 year for most patients who died over the intervening period.
Conclusion: The Oesophago-Gastric Malignancies After Obesity/Bariatric Surgery study presents the largest series to date of patients developing EG malignancies after bariatric surgery and attempts to characterize this condition.info:eu-repo/semantics/publishedVersio
NY-ESO-1-Specific Circulating CD4+ T Cells in Ovarian Cancer Patients Are Prevalently TH1 Type Cells Undetectable in the CD25+FOXP3+Treg Compartment
Spontaneous CD4+ T-cell responses to the tumor-specific antigen NY-ESO-1 (ESO) are frequently found in patients with epithelial ovarian cancer (EOC). If these responses are of effector or/and Treg type, however, has remained unclear. Here, we have used functional approaches together with recently developed MHC class II/ESO tetramers to assess the frequency, phenotype and function of ESO-specific cells in circulating lymphocytes from EOC patients. We found that circulating ESO-specific CD4+ T cells in EOC patients with spontaneous immune responses to the antigen are prevalently TH1 type cells secreting IFN-γ but no IL-17 or IL-10 and are not suppressive. We detected tetramer+ cells ex vivo, at an average frequency of 1∶25000 memory cells, that is, significantly lower than in patients immunized with an ESO vaccine. ESO tetramer+ cells were mostly effector memory cells at advanced stages of differentiation and were not detected in circulating CD25+FOXP3+Treg. Thus, spontaneous CD4+ T-cell responses to ESO in cancer patients are prevalently of TH1 type and not Treg. Their relatively low frequency and advanced differentiation stage, however, may limit their efficacy, that may be boosted by immunogenic ESO vaccines
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