The First Year IceCube-DeepCore Results

The IceCube Neutrino Observatory includes a tightly spaced inner array in the deepest ice, called DeepCore, which gives access to low-energy neutrinos with a sizable surrounding cosmic ray muon veto. Designed to be sensitive to neutrinos at energies as low as 10 GeV, DeepCore will be used to study diverse physics topics with neutrino signatures, such as dark matter annihilations and atmospheric neutrino oscillations. The first year of DeepCore physics data-taking has been completed, and the first observation of atmospheric neutrino-induced cascades with IceCube and DeepCore are presented.Comment: 4 pages, 3 figures, TAUP 2011 (Journal of Physics: Conference Series (JCPS)

Frequency reconfigurable patch antenna for 4G LTE applications

A compact printed multi-band frequency reconfigurable patch antenna for 4G LTE applications is presented in this paper (50 x 60 x 1.6 mm3). The antenna consists of W-shaped and Inverted-U shaped patch lines connected in a Tree-shape on the front side of the antenna. The back-side of the antenna contains a 90°-tilted T-shaped strip connected with an Inverted-L shaped strip which is shorted with a patch on the front side for increasing the electrical length to cover lower frequency bands. Frequency reconfigurability is achieved by inserting three switches i.e., PIN diodes. The most critical part of this work is the designing of RLC-based DC line circuits for providing the DC biasing to the PIN diodes used as switches and inserting them at optimum locations. This antenna is reconfigurable among eight different 4G LTE frequency bands including 0.9 GHz, 1.4 GHz, 1.5 GHz, 1.6 GHz, 1.7 GHz, 1.8 GHz, 2.6 GHz, 3.5 GHz and WLAN band 2.5 GHz. The antenna exhibits different radiation patterns having a different direction of peak gain at different frequencies and for different switching combinations. The antenna is simulated with CST, and a prototype is fabricated to compare the measured and simulated results with good accuracy

The Search for Anisotropy in the Arrival Directions of Ultra-High Energy Cosmic Rays Observed by the High Resolution Fly's Eye Detector in Monocular Mode

The High Resolution Fly's Eye HiRes-I detector has now been in operation in monocular mode for over six years. During that time span, HiRes-I has accumulated a larger exposure to Ultra-High Energy Cosmic Rays (UHECRs) above 10^19 eV than any other experiment built to date. This presents an unprecedented opportunity to search for anisotropy in the arrival directions of UHECRs. We present results of a search for dipole distributions oriented towards major astrophysical landmarks and a search for small-scale clustering. We conclude that the HiRes-I data set is, in fact, consistent with an isotropic source model.Comment: 6 pages, 5 figures; to appear in the proceedings of CRIS 2004, Catania, Italy, 31 May - 4 June 2004 (Nuclear Phys. B

Review on Neutrino Telescopes

I will discuss the motivations for Neutrino Astronomy and its prospects given the current experimental scenario, which is the main focus of this paper. I will also go through the first results of the IceCube detector deep in the ice and of the ANTARES undersea telescope underlying complementary aspects, common and different challenges. It is an exciting time for this science since the first completed undersea detector is successfully taking data and the first cubic kilometer detector is going to be shortly more than half-way from its completion in Antarctica.Comment: Proceeding of CRIS2008 Conference, Salina, Sept. 2008, 9 pages, 8 figure

Expression levels of vascular endothelial growth factors A and C in patients with peptic ulcers and gastric cancer

Purpose: Vascular endothelial growth factor (VEGF) is one of the most important growth factors for metastatic tumors. To clarify the role of VEGF-A and C in patients with peptic ulcer disease (PUD) or gastric cancer (GC), we evaluated the expression levels of these two molecules. We also analyzed the effect of Helicobacter pylori infection on VEGF-A and C expression levels

Techniques for measuring atmospheric aerosols at the High Resolution Fly's Eye experiment

We describe several techniques developed by the High Resolution Fly's Eye experiment for measuring aerosol vertical optical depth, aerosol horizontal attenuation length, and aerosol phase function. The techniques are based on measurements of side-scattered light generated by a steerable ultraviolet laser and collected by an optical detector designed to measure fluorescence light from cosmic-ray air showers. We also present a technique to cross-check the aerosol optical depth measurement using air showers observed in stereo. These methods can be used by future air fluorescence experiments.Comment: Accepted for publication in Astroparticle Physics Journal 16 pages, 9 figure

An overview on the small heat shock proteins

In the last 25 years, a huge amount of literature has been accumulated describing the cell’s response to different kinds of environmental stress conditions, such as high temperatures, altered pH, exposure of the cell to toxins, starvation, oxygen, and water deprivation, among others. Heat shock proteins (HSPs) are one of the main expressed products of the cell in response to stresses. HSPs can be classified into six structurally conserved classes according to their molecular weight namely, HSP100, HSP90, HSP70, HSP60, small heat shock proteins (sHSPs) and ubiquitin (8.5 kDa). In eukaryotes, different heat shock genes are expressed uncoordinatedly, whereas in prokaryote, heat shock genes form a regulon and appear simultaneously. sHSPs are associated with nuclei, cytoskeleton and membranes. They bind partially to denatured proteins, preventing irreversible protein aggregation during stress. In animals, only one sHSP gene has been located in yeast cells, ten in mammalian, two in birds and four genes have been found in Drosophila. However, in plants more than 20 sHSPs have been reported and they can be divided into 6 classes, of which, 3 classes (CI, CII and CIII) are in the cytosole or in the nucleus and the other three (CIV, CV and CVI) in the plastids, endoplasmic reticulum and mitochondria. Mitochondrial and chloroplast sHSPs protect electron transport chain. During development in animals, sHSP genes are normally regulated at late neurula and early tailbud stage and in plants during pollen development, seed maturation, seed imbibition and germination. Transcriptional regulation of sHSPs depends on particular activation of heat shock factors (HSF) which recognize the highly conserved heat-shock elements (HSEs). After the heat stress has been released, the sHSPs are quite stable, suggesting that sHSPs may be important for recovery as well

New approaches to measurement and management for high integrity health systems

Healthcare economies across the globe are in crisis. High income countries—whether their healthcare economies are market driven like the US or tax funded like the UK—are struggling with relentless demand for more services that are increasingly costly to deliver. Low and middle income countries are struggling to provide better and more equitable access to potentially lifesaving interventions while wisely allocating scarce resources across all sectors that affect human and social development. In rich and poor countries alike, policy makers, citizens, and health professionals are drawn to technology but are not learning how to use it most effectively or from mistakes made when its limits go unrecognised or unheeded.1 Variation in regional rates of therapeutic and diagnostic interventions and hospital based care exists globally with no measurable benefit in populations receiving more services.2345 At the same time effective primary healthcare and social services that can have a greater effect on health and wellbeing are being underused.467 The failure to deliver the right care at the right time in the right place contributes to the waste of as much as 40% of healthcare expenditures.48 Recognition of this waste, which is often associated with harm to patients, has spurred health policy reforms across the globe. One common objective is people centred care, which focuses on the needs and wants of individuals and engages them in management of their own care, including behaviours that promote and sustain health and wellbeing. A policy forum held earlier this year, which included health ministers and other representatives from members of the Organisation for Economic Cooperation and Development and seven other countries, advocated a shift from “a system centred on providers to one centred on people’s individual needs and preferences.” The same shift has been advocated in China and for other countries investing heavily in developing healthcare economies.91011 Reform has been successful in some settings, but nowhere has the scale of reform been sufficient to allay concerns about personalised care or about system sustainability. A high integrity health system is one dedicated to providing services that people need and want—no less but no more—and that puts the interests of patients and the public above those of all other stakeholders.12 In this analysis, we discuss how next generation reforms towards a high integrity health system will need to move from the “what” to the “how” of change, to reflect a greater understanding of the sources of resistance, and to take new approaches to measurement and management to guide system performance and innovation