150 research outputs found
Outcomes and Predictors of Early Mortality After Continuous-Flow Left Ventricular Assist Device Implantation as a Bridge to Transplantation
RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling
RhoH is an hematopoietic-specific, GTPase-deficient Rho GTPase that plays a role in T development. We investigated the mechanisms of RhoH function in TCR signaling. We found that the association between Lck and CD3ζ was impaired in RhoH-deficient T cells, due to defective translocation of both Lck and ZAP-70 to the immunological synapse. RhoH with Lck and ZAP-70 localizes in the detergent-soluble membrane fraction where the complex is associated with CD3ζ phosphorylation. To determine if impaired translocation of ZAP-70 was a major determinant of defective T cell development, Rhoh-/- bone marrow cells were transduced with a chimeric myristoylation-tagged ZAP-70. Myr-ZAP-70 transduced cells partially reversed the in vivo defects of RhoH-associated thymic development and TCR signaling. Together, our results suggest that RhoH regulates TCR signaling via recruitment of ZAP-70 and Lck to CD3ζ in the immunological synapse. Thus, we define a new function for a RhoH GTPase as an adaptor molecule in TCR signaling pathway
Canım
Selami İzzet'in Akşam'da tefrika edilen Canım adlı romanıTelif hakları nedeniyle romanın tam metni verilememiştir
Development and evaluation of real-time loop-mediated isothermal amplification assay for rapid detection of cystic echinococcosis
Less invasive coronary artery revascularization with a minimized extracorporeal circulation system: preliminary results of a comparative study with off-pump-procedures
A novel treatment strategy of new onset atrial fibrillation after cardiac surgery: an observational prospective study
Major parasitic diseases of poverty in mainland China: perspectives for better control
Stanford type B aortic dissections. Current situation in 2016 and retrospection of 1990
The treatment of type B dissection has evolved in the last few decades due to continuous development, including new interventional techniques that have been implemented into clinical treatment. Today, patients with this disease entity present less often to cardiac surgeons due to various factors, particularly due to sufficient treatment options using new interventional techniques with less trauma by vascular surgeons. The aim of this article is to present our assessment from 1990 and compare it with current knowledge and experience in the treatment of type B dissection, and to critically analyze the current situation
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