Amelioration of Little Hierarchy Problem in SU(4)_c x SU(2)_L x SU(2)_R

The little hierarchy problem encountered in the constrained minimal supersymmetric model (CMSSM) can be ameliorated in supersymmetric models based on the gauge symmetry G_{422} \equiv SU(4)_c x SU(2)_L x SU(2)_R. The standard assumption in CMSSM (and in SU(5) and SO(10)) of universal gaugino masses can be relaxed in G_{422}, and this leads to a significant improvement in the degree of fine tuning required to implement radiative electroweak breaking in the presence of a characteristic supersymmetry breaking scale of around a TeV. Examples of Higgs and sparticle mass spectra realized with 10% fine tuning are presented.Comment: 14 pages, 5 figures, 2 table

Iron(III)-catalyzed chlorination of activated arenes

A general and regioselective method for the chlorination of activated arenes has been developed. The transformation uses iron(III) triflimide as a powerful Lewis acid for the activation of N-chlorosuccinimide and the subsequent chlorination of a wide range of anisole, aniline, acetanilide and phenol derivatives. The reaction was utilized for the late-stage mono- and di-chlorination of a range of target compounds such as the natural product nitrofungin, the antibacterial agent chloroxylenol and the herbicide chloroxynil. The facile nature of this transformation was demonstrated with the development of one-pot tandem iron-catalyzed dihalogenation processes allowing highly regioselective formation of different carbon-halogen bonds. The synthetic utility of the resulting dihalogenated aryl compounds as building blocks was established with the synthesis of natural products and pharmaceutically relevant targets

RF MEMS Based Tunable Bowtie Shaped Substrate Integrated Waveguide Filter

A tunable bandpass filter based on a technique that utilizes substrate integrated waveguide (SIW) and double coupling is presented. The SIW based bandpass filter is implemented using a bowtie shaped resonator structure. The bowtie shaped filter exhibits similar performance as found in rectangular and circular shaped SIW based bandpass filters. This concept reduces the circuit foot print of SIW; along with miniaturization high quality factor is maintained by the structure. The design methodology for single-pole triangular resonator structure is presented. Two different inter-resonator couplings of the resonators are incorporated in the design of the two-pole bowtie shaped SIW bandpass filter, and switching between the two couplings using a packaged RF MEMS switch delivers the tunable filter. A tunning of 1 GHz is achieved for two frequency states of 6.3 and 7.3 GHz. The total size of the circuit is 70mm x 36mm x 0.787 mm (LxWxH)

Automotive leaf spring design and manufacturing process improvement using failure mode and effects analysis (FMEA)

Nowadays human safety and comfort are the most considerable parameters in designing and manufacturing of a vehicle, that is why every organization ensures the quality and reliability of components used in the vehicle. Leaf spring is also a component of vehicle which plays an important role in human safety and comfort. It acts as a structural member and an integral part of suspension system. It is important to eliminate the failures in designing and manufacturing process of leaf springs because of its importance in functionality and safety of vehicle. In this research, failure mode and effects analysis has been used to analyze and reduce the risks of 42 possible failures that can occur in automotive leaf spring. It starts from determining, classifying, and analyzing all potential failures and then rating them with the help numeric scores. The four numeric scores namely severity, occurrence, detection, and Risk Priority Number (RPN) are used to find the high potential failures of semi-elliptical leaf springs. In the end, actions are recommended for RPN greater than 250, to increase quality and reliably of product. </jats:p

Federated learning for medical imaging radiology

Federated learning (FL) is gaining wide acceptance across the medical AI domains. FL promises to provide a fairly acceptable clinical-grade accuracy, privacy, and generalisability of machine learning models across multiple institutions. However, the research on FL for medical imaging AI is still in its early stages. This paper presents a review of recent research to outline the difference between state-of-the-art [SOTA] (published literature) and state-of-the-practice [SOTP] (applied research in realistic clinical environments). Furthermore, the review outlines the future research directions considering various factors such as data, learning models, system design, governance, and human-in-loop to translate the SOTA into SOTP and effectively collaborate across multiple institutions

A miniaturized series fed tri-slot coplanar Vivaldi antenna for RADAR application with reduced ground plane effect

In this article, a printed series fed tri-slot coplanar Vivaldi antenna is studied and investigated for RADAR application. The antenna consists of three exponentially tapered slots excited by a single microstrip line. The three slots are series fed simultaneously with a radial stub on the microstrip feed line for impedance matching. The proposed antenna covers a frequency of 7.8-11.8 GHz at -10 dB impedance bandwidth. The antenna gain varies from 7.5 dB at the lowest operating frequency and increases to around 9.5 dB at the center frequency of 10 GHz. A key versatility of the proposed design is the ability to modify the ground plane size without affecting the antenna impedance and gain. This makes the antenna suitable to incorporate RADAR transceiver components without modifying the existing antenna design. The proposed antenna is fabricated and measured results show good agreement with simulated results

Design and study of a small implantable antenna design for blood glucose monitoring

In this paper, a miniaturized implantable antenna with the dimensions of 8×8×1 mm3 has been studied for continuous monitoring of Blood Glucose Levels (BGL). The antenna performance is analyzed numerically for both the free space and implanted operation. The results show that the works excellently in both the scenarios. The antenna has the lowest resonant frequency of 3.58 GHz in free space with a gain 1.18 GHz while it operates at 2.58 GHz with a gain of 4.18 dBi. Good performance, small size and resilience to the human body effects make the antenna to have a good potential use in future implantable glucose monitoring devices

Developing a New Bursting Liability Index Based on Energy Evolution for Coal under Different Loading Rates

The risk of a coal burst rises with the excavation depth and other mining-related activities. These devastating coal burst activities are a major concern during deep coal mining. During such activities, the loading rate is a major cause of damage. Different indexes, including the elastic strain modulus index (Wet), bursting energy index (Ke), dynamic failure time index (DT), and compressive strength index (Rc), are used for coal bursting intensity; however, the loading rate and damage factors are not included in these indexes. In this study, a new coal bursting liability index called the elastic modulus damage index (EMDI) was developed using rock damage variables and the elastic strain modulus index, and is based on energy evolution characteristics under different loading rates. The results of this new index were compared with the existing indexes, and their range was proposed to evaluate coal bursting liability. The EDMI shows a positive polynomial second order degree relationship with Wet and Ke, having a determination factor of 0.99, while DT shows a negative polynomial second order degree relationship with a determination factor of 0.94. The EDMI and Rc show a positive power relationship having a determination factor of 0.99. The relationships with other indexes revealed that the EDMI can be effectively used in evaluating the coal bursting liabilities in different stress environments. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Funding: The authors would like to thank the YUTP under grant numbers 015LC0-150 and 015LC0-326 for providing financial assistance

Indirect Enzyme Linked Immunosorbent Assay for Diagnosis of Brucellosis in Buffaloes

Brucellosis is an important zoonotic disease causing significant economic losses worldwide. Early detection of this disease is essential for its control and eradication. Presently, an Indirect Enzyme Linked Immunosorbent Assay (I-ELISA) was developed using lipopolysaccharide (LPS) as antigen and compared with the commercial kit using one hundred negative and positive sera each from buffaloes. The agreement for the positive result between the developed and commercial I-ELISA was 78% and for the negative it was 100%. At 52.49%, 53.09%, 53.26%, 53.86% and 53.94% cut off the sensitivity was 100%, 100%, 97.53%, 88.93% and 86.42%, while the specificity was 84.03%, 84.87%, 85.71%, 87.39% and 87.39%, respectively, for developed I-ELISA. This developed test can be used for the screening of herds as the relative sensitivity is higher

Testing oxygenated microbubbles via intraperitoneal and intrathoracic routes on a large pig model of LPS-induced acute respiratory distress syndrome

With a mortality rate of 46% before the onset of COVID-19, acute respiratory distress syndrome (ARDS) affected 200,000 people in the US, causing 75,000 deaths. Mortality rates in COVID-19 ARDS patients are currently at 39%. Extrapulmonary support for ARDS aims to supplement mechanical ventilation by providing life-sustaining oxygen to the patient. A new rapid-onset, human-sized pig ARDS model in a porcine intensive care unit (ICU) was developed. The pigs were nebulized intratracheally with a high dose (4 mg/kg) of the endotoxin lipopolysaccharide (LPS) over a 2 h duration to induce rapid-onset moderate-to- severe ARDS. They were then catheterized to monitor vitals and to evaluate the therapeutic effect of oxygenated microbubble (OMB) therapy delivered by intrathoracic (IT) or intraperitoneal (IP) administration. Post-LPS administration, the PaO2 value dropped below 70 mmHg, the PaO2/FiO2 ratio dropped below 200 mmHg, and the heart rate increased, indicating rapidly developing (within 4 h) moderate-to- severe ARDS with tachycardia. The SpO2 and PaO2 of these LPS-injured pigs did not show significant improvement after OMB administration, as they did in our previous studies of the therapy on small animal models of ARDS injury. Furthermore, pigs receiving OMB or saline infusions had slightly lower survival than their ARDS counterparts. The OMB administration did not induce a statistically significant or clinically relevant therapeutic effect in this model; instead, both saline and OMB infusion appeared to lower survival rates slightly. This result is significant because it contradicts positive results from our previous small animal studies and places a limit on the efficacy of such treatments for larger animals under more severe respiratory distress. While OMB did not prove efficacious in this rapid-onset ARDS pig model, it may retain potential as a novel therapy for the usual presentation of ARDS in humans, which develops and progresses over days to weeks