Viscosity Dependence of the Folding Rates of Proteins

The viscosity dependence of the folding rates for four sequences (the native state of three sequences is a beta-sheet, while the fourth forms an alpha-helix) is calculated for off-lattice models of proteins. Assuming that the dynamics is given by the Langevin equation we show that the folding rates increase linearly at low viscosities \eta, decrease as 1/\eta at large \eta and have a maximum at intermediate values. The Kramers theory of barrier crossing provides a quantitative fit of the numerical results. By mapping the simulation results to real proteins we estimate that for optimized sequences the time scale for forming a four turn \alpha-helix topology is about 500 nanoseconds, whereas the time scale for forming a beta-sheet topology is about 10 microseconds.Comment: 14 pages, Latex, 3 figures. One figure is also available at http://www.glue.umd.edu/~klimov/seq_I_H.html, to be published in Physical Review Letter

Ethnobotanical Study of Medicinal Plants used by the Local People in Vellore District, Tamilnadu, India

An ethnobotanical survey was conducted in and around Vellore district to study the various medicinal plants used by the people for the treatment of their ailments such as fever, cold, cough, diabetes, jaundice, diarrhoea, rheumatism, snake bite, and headache. The study also covered the methods used in plant extraction, and the dose, duration and mode of application

Transient Thermal Stresses In A Sphere By Local Heating

The problem of transient thermal stresses in a solid, elastic, homogeneous, and isotropic sphere is solved for uniform and nonuniform, local surface heating. The temperature solutions are obtained by using separation of variables and integral transformation. The corresponding thermal stresses are derived by superposing a particular displacement potential function on Boussinesq solutions. Numerical solutions for two particular cases of localized heating of a typical brittle spherical solid have been obtained and presented. The results indicate a tensile stress concentration in the interior of the solid below the heated zone. © 1974 by ASME

Magnetic field stabilization system for atomic physics experiments

Atomic physics experiments commonly use millitesla-scale magnetic fields to provide a quantization axis. As atomic transition frequencies depend on the amplitude of this field, many experiments require a stable absolute field. Most setups use electromagnets, which require a power supply stability not usually met by commercially available units. We demonstrate stabilization of a field of 14.6 mT to 4.3 nT rms noise (0.29 ppm), compared to noise of $\gtrsim$ 100 nT without any stabilization. The rms noise is measured using a field-dependent hyperfine transition in a single $^{43}$Ca$^+$ ion held in a Paul trap at the centre of the magnetic field coils. For the $^{43}$Ca$^+$ "atomic clock" qubit transition at 14.6 mT, which depends on the field only in second order, this would yield a projected coherence time of many hours. Our system consists of a feedback loop and a feedforward circuit that control the current through the field coils and could easily be adapted to other field amplitudes, making it suitable for other applications such as neutral atom traps.Comment: 6 pages, 5 figure