The effect of carnitine on random-pattern flap survival in rats

YILMAZ, TANER/0000-0001-8999-3237WOS: 000170901100021PubMed: 11547153Carnitine is an endogenous cofactor involved in the transport of long-chain fatty acids into the mitochondria where they undergo P-oxidation. Through another reaction, carnitine produces free coenzyme A and reduces the ratio of acetyl-coenzyme A to coenzyme A, thereby enhancing oxidative use of glucose, augmenting adenosine triphosphate synthesis, and reducing lactate production and acidosis. Because of its regulatory action on the energy flow from the different oxidative sources, especially under ischemic conditions, carnitine has been used in cardiovascular diseases such as coronary heart disease, congestive heart failure, peripheral vascular disease, dyslipidemia, diabetes, and chronic renal diseases with satisfactory results. A flap is also a relatively ischemic tissue and may obtain benefit from carnitine. To investigate this, 30 rats were divided into three groups of 10 animals: a control group and two carnitine-treated groups. Random dorsal skin flaps were elevated on the rats. In the control group, no pharmacologic agents were used. Of the two treated groups, group I was treated with 50 mg/kg/day carnitine for I week and group 2 was treated with 100 mg/kg/day carnitine for I week. The areas of flap necrosis were measured in each group. The median areas of flap necrosis of the groups were 12.55, 9.23, and 4.9 cm(2), respectively. There was a statistically significant improvement of flap necrosis in carnitine-treated groups compared with the control group (group 2, p = 0.001; group 3, p = 0.000). Furthermore, there was less necrosis in the high-dose carnitine-treated group than the low-dose carnitine-treated group. As a conclusion, carnitine may have a dose-dependent effect to increase flap survival in random skin flaps

Keloid of the circumcision scar: a rare complication

durgun, mustafa/0000-0002-0811-9175WOS: 000363810700025PubMed: 24750852

Co-Creation Practices and Technologies for Open Urban Planning

With this workshop, we aim to provide a forum for participants populated by researchers, urban planners, co-creation facilitators, and representatives of municipalities to share their experiences with co-creation tools and methods in urban planning. We focus on reflecting on key issues based on CSCW (Computer Supported Cooperative Work) and PD (Participatory Design) concepts and approaches regarding engagement, participation, and consensus-making in technology-supported co-creation processes. By concentrating on spatial and urban planning practices, we will connect above mentioned actors to discuss different participation and co-creation processes among disciplines. After briefly introducing state-of-the-art co-creation techniques, Design Thinking approaches connected with supporting technologies will be examined and evaluated in group discussions by informing the presented practices with theories and concepts from CSCW and PD research