Carbon Capture and Storage

Emissions of carbon dioxide, the most important long-lived anthropogenic greenhouse gas, can be reduced by Carbon Capture and Storage (CCS). CCS involves the integration of four elements: CO 2 capture, compression of the CO2 from a gas to a liquid or a denser gas, transportation of pressurized CO 2 from the point of capture to the storage location, and isolation from the atmosphere by storage in deep underground rock formations. Considering full life-cycle emissions, CCS technology can reduce 65–85% of CO2 emissions from fossil fuel combustion from stationary sources, although greater reductions may be possible if low emission technologies are applied to activities beyond the plant boundary, such as fuel transportation. CCS is applicable to many stationary CO2 sources, including the power generation, refining, building materials, and the industrial sector. The recent emphasis on the use of CCS primarily to reduce emissions from coal-fired electricity production is too narrow a vision for CCS. Interest in CCS is growing rapidly around the world. Over the past decade there has been a remarkable increase in interest and investment in CCS. Whereas a decade ago, there was only one operating CCS project and little industry or government investment in R&D, and no financial incentives to promote CCS. In 2010, numerous projects of various sizes are active, including at least five large-scale full CCS projects. In 2015, it is expected that 15 large-scale, full-chain CCS projects will be running. Governments and industry have committed over USD 26 billion for R&D, scale-up and deployment. The technology for CCS is available today, but significant improvements are needed to support widespread deployment. Technology advances are needed primarily to reduce the cost of capture and increase confidence in storage security. Demonstration projects are needed to address issues of process integration between CO2 capture and product generation, for instance in power, cement and steel production, obtain cost and performance data, and for industry where capture is more mature to gain needed operational experience. Large-scale storage projects in saline aquifers are needed to address issues of site characterization and site selection, capacity assessment, risk management and monitoring. Successful experiences from five ongoing projects demonstrate that, at least on this limited scale, CCS can be safe and effective for reducing emissions. Five commercial-scale CCS projects are operational today with over 35 million tonnes of CO2 captured and stored since 1996. Observations from commercial storage projects, commercial enhanced oil recovery projects, engineered and natural analogues as well as theoretical considerations, models, and laboratory experiments suggest that appropriately selected and managed geological storage reservoirs are very likely to retain nearly all the injected CO2 for very long times, more than long enough to provide benefits for the intended purpose of CCS. Significant scale-up compared to existing CCS activities will be needed to achieve large reductions in CO2 emissions. A 5- to 10-fold scale-up in the size of individual projects is needed to capture and store emissions from a typical coal-fired power plant (500 to 1000 MW). A thousand fold scale-up in size of today’s CCS enterprise would be needed to reduce emissions by billions of tonnes per year (Gt/yr). The technical potential of CCS on a global level is promising, but on a regional level is differentiated. The primary technical limitation for CCS is storage capacity. Much more work needs to be done to realistically assess storage capacity on a worldwide, regional basis and sub-regional basis. Worldwide storage capacity estimation is improving but more experience is needed. Estimates for oil and gas reservoirs are about 1000 GtCO2, saline aquifers are estimated to have a capacity ranging from about 4000 to 23,000 GtCO2. However, there is still considerable debate about how much storage capacity actually exists, particularly in saline aquifers. Research, geological assessments and, most importantly, commercial-scale demonstration projects will be needed to improve confidence in capacity estimates. Costs and energy requirements for capture are high. Estimated costs for CCS vary widely, depending on the application (e.g. gas clean-up vs. electricity generation), the type of fuel, capture technology, and assumptions about the baseline technology. For example, with today’s technology, CCS would increase cost of generating electricity by 50–100%. In this case, capital costs and parasitic energy requirements of 15–30% are the major cost drivers. Research is underway to lower costs and energy requirements. Early demonstration projects are likely to cost more. The combination of high cost and low or absent incentives for large-scale deployment are a major factor limiting the widespread use of CCS. Due to high costs, CCS will not take place without strong incentives to limit CO2 emissions. Certainty about the policy and regulatory regimes will be crucial for obtaining access to capital to build these multi-billion dollar projects. Environmental risks of CCS appear manageable, but regulations are needed. Regulation needs to ensure due diligence over the lifecycle of the project, but should, most importantly, also govern site selection, operating guidelines, monitoring and closure of a storage facility. Experience so far has shown that local resistance to CO2 storage projects may appear and can lead to cancellation of planned CCS projects. Inhabitants of the areas around geological storage sites often have concerns about the safety and effectiveness of CCS. More CCS projects are needed to establish a convincing safety record. Early engagement of communities in project design and site selection as well as credible communication can help ease resistance. Environmental organisations sometimes see CCS as a distraction from a sustainable energy future. Social, economic, policy and political factors may limit deployment of CCS if not adequately addressed. Critical issues include ownership of underground pore space (primarily an issue in the US); long-term liability and stewardship; GHG accounting approaches and ve rification; and regulatory oversight regimes. Governments and the private sector are making significant progress on all of these issues. Government support to lower barriers for early deployments is needed to encourage private sector adoption. Developing countries will need support for technology access, lowering the cost of CCS, developing workforce capacity and training regulators for permitting, monitoring and oversight. CCS combined with biomass can lead to negative emissions . Such technologies are likely to be needed to achieve atmospheric stabilization of CO2 and may provide an additional incentive for CCS adoption

Binding and metabolism of platelet-activating factor by human neutrophils.

Human polymorphonuclear neutrophils rapidly incorporated radiolabeled platelet-activating factor, 1-O-[hexadecyl-9, 10-3H2]-2-acetyl-sn-glycero-3-phosphocholine ([3H]PAF), and then metabolized it into its sn-2-fatty acyl derivative. Fractionation of radiolabel-pretreated cells over Percoll gradients revealed that virtually all of the intact [3H]PAF was located in nongranule membranes that were enriched with alkaline phosphatase and cell surface glycoproteins. While still membrane associated, the ligand was rapidly converted to its acyl derivative and then more slowly transferred to specific granules and, to a lesser extent, azurophilic granules. In contrast, neutrophils did not metabolize [3H]PAF at 4 degrees C but rather gradually accumulated it in their alkaline phosphatase-enriched membrane subfractions. These same subfractions contained receptors for the ligand, as determined by their capacity to bind [3H]PAF specifically. Binding was readily saturated, partially reversible, and fit a two receptor model; dissociation constant (Kd) values for high and low affinity sites were 0.2 and 500 nM, respectively. Receptors with similar affinities were detected in whole cells. Furthermore, the potencies of several structural analogues in inhibiting binding of [3H]PAF to membranes correlated closely with their respective potencies in stimulating degranulation responses. Finally, quantitative studies suggested all or most of the cell's receptors were membrane associated. We conclude that PAF rapidly enters cellular membranes to bind with specific receptors that trigger function. The intramembranous ligand is also deacetylated, acylated, and then transferred to granules. This metabolism may be sufficiently rapid to limit ligand-receptor binding and distort quantitative analyses of receptors

Control Charts for Monitoring Burr Type-X Percentiles

[[abstract]]When the sampling distribution of a parameter estimator is unknown, using normality asymptotically, the Shewhart-type chart may provide improper control limits. To monitor Burr type-X percentiles, two parametric bootstrap charts (PBCs) are proposed and compared with the Shewhart-type chart via a Monte Carlo simulation. Simulation results exhibit that the proposed PBCs perform well with a short average run length to signal out-of-control when the process is out-of-control, and have more adequate control limits than the Shewhart-type chart in view of in-control false alarm rate. An example regarding single fiber strength is presented for illustrating the proposed PBCs.[[incitationindex]]SCI[[booktype]]紙

Neuron Names: A Gene- and Property-Based Name Format, With Special Reference to Cortical Neurons

Precision in neuron names is increasingly needed. We are entering a new era in which classical anatomical criteria are only the beginning toward defining the identity of a neuron as carried in its name. New criteria include patterns of gene expression, membrane properties of channels and receptors, pharmacology of neurotransmitters and neuropeptides, physiological properties of impulse firing, and state-dependent variations in expression of characteristic genes and proteins. These gene and functional properties are increasingly defining neuron types and subtypes. Clarity will therefore be enhanced by conveying as much as possible the genes and properties in the neuron name. Using a tested format of parent-child relations for the region and subregion for naming a neuron, we show how the format can be extended so that these additional properties can become an explicit part of a neuron’s identity and name, or archived in a linked properties database. Based on the mouse, examples are provided for neurons in several brain regions as proof of principle, with extension to the complexities of neuron names in the cerebral cortex. The format has dual advantages, of ensuring order in archiving the hundreds of neuron types across all brain regions, as well as facilitating investigation of a given neuron type or given gene or property in the context of all its properties. In particular, we show how the format is extensible to the variety of neuron types and subtypes being revealed by RNA-seq and optogenetics. As current research reveals increasingly complex properties, the proposed approach can facilitate a consensus that goes beyond traditional neuron types

Conserved amino acids in each subunit of the heteroligomeric tRNA m1A58 Mtase from Saccharomyces cerevisiae contribute to tRNA binding

In Saccharomyces cerevisiae, a two-subunit methyltransferase (Mtase) encoded by the essential genes TRM6 and TRM61 is responsible for the formation of 1-methyladenosine, a modified nucleoside found at position 58 in tRNA that is critical for the stability of tRNAiMet. The crystal structure of the homotetrameric m1A58 tRNA Mtase from Mycobacterium tuberculosis, TrmI, has been solved and was used as a template to build a model of the yeast m1A58 tRNA Mtase heterotetramer. We altered amino acids in TRM6 and TRM61 that were predicted to be important for the stability of the heteroligomer based on this model. Yeast strains expressing trm6 and trm61 mutants exhibited growth phenotypes indicative of reduced m1A formation. In addition, recombinant mutant enzymes had reduced in vitro Mtase activity. We demonstrate that the mutations introduced do not prevent heteroligomer formation and do not disrupt binding of the cofactor S-adenosyl-l-methionine. Instead, amino acid substitutions in either Trm6p or Trm61p destroy the ability of the yeast m1A58 tRNA Mtase to bind tRNAiMet, indicating that each subunit contributes to tRNA binding and suggesting a structural alteration of the substrate-binding pocket occurs when these mutations are present