22 research outputs found
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The Abuse of Confidence as a Major Theme in the Novels of Henry James
All of the aforementioned factors--love, money, the abuse of confidence, the guilt growing out of it, the response of the victim--contribute to the moral view constantly evolving towards an ultimate statement in the three novels of James's maturity. This thesis will attempt to explicate in full that statement. For James's theme of abuse of confidence, together with all of its elements, was in itself only the vehicle of a finely attuned moral awareness
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Portable database driven control system for SPEAR
The new computer control system software for SPEAR is presented as a transfer from the PEP system. Features of the target ring (SPEAR) such as symmetries, magnet groupings, etc., are all contained in a design file which is read by both people and computer. People use it as documentation; a program reads it to generate the database structure, which becomes the center of communication for all the software. Geometric information, such as element positions and lengths, and CAMAC I/O routing information is entered into the database as it is developed. Since application processes refer only to the database and since they do so only in generic terms, almost all of this software (representing more then fifteen man years) is transferred with few changes. Operator console menus (touchpanels) are also transferred with only superficial changes for the same reasons. The system is modular: the CAMAC I/O software is all in one process; the menu control software is a process; the ring optics model and the orbit model are separate processes, each of which runs concurrently with about 15 others in the multiprogramming environment of the VAX/VMS operating system. 10 refs., 1 fig
A DNA repair protein and histone methyltransferase interact to promote genome stability in the Caenorhabditis elegans germ line.
Histone modifications regulate gene expression and chromosomal events, yet how histone-modifying enzymes are targeted is poorly understood. Here we report that a conserved DNA repair protein, SMRC-1, associates with MET-2, the C. elegans histone methyltransferase responsible for H3K9me1 and me2 deposition. We used molecular, genetic, and biochemical methods to investigate the biological role of SMRC-1 and to explore its relationship with MET-2. SMRC-1, like its mammalian ortholog SMARCAL1, provides protection from DNA replication stress. SMRC-1 limits accumulation of DNA damage and promotes germline and embryonic viability. MET-2 and SMRC-1 localize to mitotic and meiotic germline nuclei, and SMRC-1 promotes an increase in MET-2 abundance in mitotic germline nuclei upon replication stress. In the absence of SMRC-1, germline H3K9me2 generally decreases after multiple generations at high culture temperature. Genetic data are consistent with MET-2 and SMRC-1 functioning together to limit replication stress in the germ line and in parallel to promote other germline processes. We hypothesize that loss of SMRC-1 activity causes chronic replication stress, in part because of insufficient recruitment of MET-2 to nuclei