Effects of hemodialysis on circulating adrenomedullin concentrations in patients with end-stage renal disease

To characterize the determinants of circulating levels of adrenomedullin (AM), the plasma levels of this peptide were measured in 58 patients with end-stage renal disease on hemodialysis, Predialysis plasma levels of AM were more than twice as high in patients on hemodialysis as compared to controls. In hemodialysis patients with heart failure (NYHA classes II-IV) or hypertensive HD patients plasma levels of AM were significantly higher than in patients with end-stage renal disease only. Plasma levels of AM were clot altered immediately by hemodialysis but decreased significantly 14-20 h after hemodialysis, AM plasma levels before hemodialysis and 14-20 h after hemodialysis were correlated with the corresponding mean arterial pressure

On Gravitational Waves in Spacetimes with a Nonvanishing Cosmological Constant

We study the effect of a cosmological constant $\Lambda$ on the propagation and detection of gravitational waves. To this purpose we investigate the linearised Einstein's equations with terms up to linear order in $\Lambda$ in a de Sitter and an anti-de Sitter background spacetime. In this framework the cosmological term does not induce changes in the polarization states of the waves, whereas the amplitude gets modified with terms depending on $\Lambda$. Moreover, if a source emits a periodic waveform, its periodicity as measured by a distant observer gets modified. These effects are, however, extremely tiny and thus well below the detectability by some twenty orders of magnitude within present gravitational wave detectors such as LIGO or future planned ones such as LISA.Comment: 8 pages, 4 figures, accepted for publication in Physical Review

Experimental Designs for Binary Data in Switching Measurements on Superconducting Josephson Junctions

We study the optimal design of switching measurements of small Josephson junction circuits which operate in the macroscopic quantum tunnelling regime. Starting from the D-optimality criterion we derive the optimal design for the estimation of the unknown parameters of the underlying Gumbel type distribution. As a practical method for the measurements, we propose a sequential design that combines heuristic search for initial estimates and maximum likelihood estimation. The presented design has immediate applications in the area of superconducting electronics implying faster data acquisition. The presented experimental results confirm the usefulness of the method. KEY WORDS: optimal design, D-optimality, logistic regression, complementary log-log link, quantum physics, escape measurement

Is There Really a de Sitter/CFT Duality

In this paper a de Sitter Space version of Black Hole Complementarity is formulated which states that an observer in de Sitter Space describes the surrounding space as a sealed finite temperature cavity bounded by a horizon which allows no loss of information. We then discuss the implications of this for the existence of boundary correlators in the hypothesized dS/cft correspondence. We find that dS complementarity precludes the existence of the appropriate limits. We find that the limits exist only in approximations in which the entropy of the de Sitter Space is infinite. The reason that the correlators exist in quantum field theory in the de Sitter Space background is traced to the fact that horizon entropy is infinite in QFT.Comment: 12 Figures, STIAS Workshop on Quantum Gravit

Innovative system identification methods for monitoring applications

Monitoring the modal parameters of civil and mechanical system received plenty of interest the last decades. Several approaches have been proposed and successfully applied in civil engineering for structural health monitoring of bridges (mainly based on the monitoring of the resonant frequencies and mode shapes). In applications such as the monitoring of offshore wind turbines and flight flutter testing the monitoring of the damping ratios are essential. For offshore wind turbine monitoring the presence of time-varying harmonic components, close to the modes of interest, can complicate the identification process. The difficulty related to flight flutter testing is that, in general, only short data records are available. The aim of this contribution is to introduce system identification methods and monitoring strategies that result in more reliable decisions and that can cope with complex monitoring applications. Basic concepts of system identification will be recapitulated with attention for monitoring aspects. The proposed monitoring methodology is based on the recently introduced Transmissibility-based Operational Modal Analysis (TOMA) approach

A Note on the Integral Formulation of Einstein's Equations Induced on a Braneworld

We revisit the integral formulation (or Green's function approach) of Einstein's equations in the context of braneworlds. The integral formulation has been proposed independently by several authors in the past, based on the assumption that it is possible to give a reinterpretation of the local metric field in curved spacetimes as an integral expression involving sources and boundary conditions. This allows one to separate source-generated and source-free contributions to the metric field. As a consequence, an exact meaning to Mach's Principle can be achieved in the sense that only source-generated (matter fields) contributions to the metric are allowed for; universes which do not obey this condition would be non-Machian. In this paper, we revisit this idea concentrating on a Randall-Sundrum-type model with a non-trivial cosmology on the brane. We argue that the role of the surface term (the source-free contribution) in the braneworld scenario may be quite subtler than in the 4D formulation. This may pose, for instance, an interesting issue to the cosmological constant problem.Comment: 10 pages, no figures, accepted for publication in the General Relativity and Gravitation Journa

Merging transcriptomics and metabolomics - advances in breast cancer profiling

Background Combining gene expression microarrays and high resolution magic angle spinning magnetic resonance spectroscopy (HR MAS MRS) of the same tissue samples enables comparison of the transcriptional and metabolic profiles of breast cancer. The aim of this study was to explore the potential of combining these two different types of information. Methods Breast cancer tissue from 46 patients was analyzed by HR MAS MRS followed by gene expression microarrays. Two strategies were used to combine the gene expression and metabolic data; first using multivariate analyses to identify different groups based on gene expression and metabolic data; second correlating levels of specific metabolites to transcripts to suggest new hypotheses of connections between metabolite levels and the underlying biological processes. A parallel study was designed to address experimental issues of combining microarrays and HR MAS MRS. Results In the first strategy, using the microarray data and previously reported molecular classification methods, the majority of samples were classified as luminal A. Three subgroups of luminal A tumors were identified based on hierarchical clustering of the HR MAS MR spectra. The samples in one of the subgroups, designated A2, showed significantly lower glucose and higher alanine levels than the other luminal A samples, suggesting a higher glycolytic activity in these tumors. This group was also enriched for genes annotated with Gene Ontology (GO) terms related to cell cycle and DNA repair. In the second strategy, the correlations between concentrations of myo-inositol, glycine, taurine, glycerophosphocholine, phosphocholine, choline and creatine and all transcripts in the filtered microarray data were investigated. GO-terms related to the extracellular matrix were enriched among the genes that correlated the most to myo-inositol and taurine, while cell cycle related GO-terms were enriched for the genes that correlated the most to choline. Additionally, a subset of transcripts was identified to have slightly altered expression after HR MAS MRS and was therefore removed from all other analyses. Conclusions Combining transcriptional and metabolic data from the same breast carcinoma sample is feasible and may contribute to a more refined subclassification of breast cancers as well as reveal relations between metabolic and transcriptional levels. See Commentary: http://www.biomedcentral.com/1741-7015/8/7

Bulk Scale Factor at Very Early Universe

In this paper we propose a higher dimensional Cosmology based on FRW model and brane-world scenario. We consider the warp factor in the brane-world scenario as a scale factor in 5-dimensional generalized FRW metric, which is called as bulk scale factor, and obtain the evolution of it with space-like and time-like extra dimensions. It is then showed that, additional space-like dimensions can produce exponentially bulk scale factor under repulsive strong gravitational force in the empty universe at a very early stage.Comment: 7 pages, October 201

Revisiting Weyl's calculation of the gravitational pull in Bach's two-body solution

When the mass of one of the two bodies tends to zero, Weyl's definition of the gravitational force in an axially symmetric, static two-body solution can be given an invariant formulation in terms of a force four-vector. The norm of this force is calculated for Bach's two-body solution, that is known to be in one-to-one correspondence with Schwarzschild's original solution when one of the two masses l, l' is made to vanish. In the limit when, say, l' goes to zero, the norm of the force divided by l' and calculated at the position of the vanishing mass is found to coincide with the norm of the acceleration of a test body kept at rest in Schwarzschild's field. Both norms happen thus to grow without limit when the test body (respectively the vanishing mass l') is kept at rest in a position closer and closer to Schwarzschild's two-surface.Comment: 11 pages, 2 figures. Text to appear in Classical and Quantum Gravit