Electrochemical reduction of carbamazepine in ethanol and water solutions using a glassy carbon electrode

The electrochemical reduction of carbamazepine in ethanol and water using a glassy carbon electrode has been studied. In all experimental conditions of scan rate and concentration of carbamazepine an irreversible cathodic wave was observed by cyclic voltammetry (CV). Electrochemical parameters and a plausible EqC mechanism have been reported from the electrochemical measurements and digital simulation. The values of thermodynamic E1/2 were correlated with solvent polarity parameters that it can be interesting for biological, pharmaceutical and forensic purposes. Limits of Detection (LOD) for DPV are 1.1 and 9.0 g/mL (4.65x10-6 and 3.81x10-5 M) in ethanol and water, respectively. The precision and recoveries obtained for tablets and plasma samples showed that the method could be successfully used for analysis

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Flavour constraints on scenarios with two or three heavy squark generations

We re-assess constraints from flavour-changing neutral currents in the kaon system on supersymmetric scenarios with a light gluino, two heavy generations of squarks and a lighter third generation. We compute for the first time limits in scenarios with three heavy squark families, taking into account QCD corrections at the next-to-leading order. We compare our limits with those in the case of two heavy families. We use the mass insertion approximation and consider contributions from gluino exchange to constrain the mixing between the first and second squark generation. While it is not possible to perform a general analysis, we assess the relevance of each kind of flavour- and CP-violating parameters. We also provide ready to use magic numbers for the computation of the Wilson coefficients at 2 GeV for these scenarios.Comment: 23 pages, 14 figures; v3: matches published version (contains improvements in the presentation and clarifications

Leptogenesis and μ−τ\mu-\tau symmetry

If an exact $\mu\leftrightarrow \tau$ symmetry is the explanation of the maximal atmospheric neutrino mixing angle, it has interesting implications for origin of matter via leptogenesis in models where small neutrino masses arise via the seesaw mechanism. For seesaw models with two right handed neutrinos $(N_\mu, N_\tau)$, lepton asymmetry vanishes in the exact $\mu\leftrightarrow \tau$ symmetric limit, even though there are nonvanishing Majorana phases in the neutrino mixing matrix. On the other hand, for three right handed neutrino models, lepton asymmetry nonzero and is given directly by the solar mass difference square. We also find an upper bound on the lightest neutrino mass.Comment: 5 pages; latex; no figures; some typos correcte

Leukocyte adhesion deficiency-I: A comprehensive review of all published cases

Leukocyte adhesion deficiency-I (LAD-I) is a rare, serious disorder with severity determined by defective CD18 expression. LAD-I is characterized by umbilical complications, granulocytosis, and diverse infections. Severe LAD-I is frequently fatal before the age of 2 years without allogeneic transplant. We identified 323 cases published between 1975 and 2017

Electrochemical behaviour of gamma hydroxybutyric acid at a platinum electrode in acidic medium

The electrooxidation of Gamma Hydroxybutyric Acid (GHB) on a polycrystalline platinum electrode is studied by cyclic voltammetry in acidic medium. Two oxidation peaks, A and B, are obtained in the positive scan within the potential range of the double layer region and of the platinum oxide region, respectively. In the negative going potential sweep an inverted oxidation peak with an onset partially overlapping with the tail of the cathodic peak for the reduction of the platinum oxide formed during the anodic scan is obtained (peak C). This inverted peak can be observed at a potential close to +0.2 V (vs Ag/AgCl at pH 2) and separated 0.4 and 0.8 V from the two other oxidation peaks obtained during the anodic scan and in such conditions that the surface is particularly activated to favour this electrochemical process. The response obtained in the electronic current for the different peaks when GHB concentration and scan rate were changed to allows inferring that these are the result of a potential dependent mechanism. The behaviour observed is according with the oxidation of the alcohol group to the corresponding aldehyde and carboxylic acid (succinic acid) as main products