Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase

The peptides angiotensin IV and LVV-hemorphin 7 were found to enhance memory in a number of memory tasks and reverse the performance deficits in animals with experimentally induced memory loss. These peptides bound specifically to the enzyme insulin-regulated aminopeptidase (IRAP), which is proposed to be the site in the brain that mediates the memory effects of these peptides. However, the mechanism of action is still unknown but may involve inhibition of the aminopeptidase activity of IRAP, since both angiotensin IV and LVV-hemorphin 7 are competitive inhibitors of the enzyme. IRAP also has another functional domain that is thought to regulate the trafficking of the insulin-responsive glucose transporter GLUT4, thereby influencing glucose uptake into cells. Although the exact mechanism by which the peptides enhance memory is yet to be elucidated, IRAP still represents a promising target for the development of a new class of cognitive enhancing agents

Corrigendum: Overview of Cattle Diseases Listed Under Category C, D or E in the Animal Health Law for Which Control Programmes Are in Place Within Europe (Front. Vet. Sci., (2021), 8, (688078), 10.3389/fvets.2021.688078)

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First identification of Zn 58 β -delayed proton emission

7 pags., 6 figs., 2 tabs.The β decay of Zn57 and Zn58 was investigated in an experiment at the National Superconducting Cyclotron Laboratory of Michigan State University. For the first time β-delayed proton emission from Zn58 was observed with a branching ratio of 0.7(1)%. The proton-energy spectrum allowed for probing the Gamow-Teller strength distribution above the proton-separation energy in the daughter nucleus. Moreover, the absolute branching ration for delayed-proton emission from Zn57 was found to be compatible with 100%.Operation of the NSCL was supported by the National Science Foundation under Grant PHY-1102511. This work was supported by the National Science Center, Poland, under Contract No. UMO-2015/17/B/ST2/00581, by the US Department of Energy, Office of Science, Office of Nuclear Physics, under US DOE Grants No. DE-AC05-00OR22725 (ORNL) and No. DE-FG02-96ER40983 (UTK), by the fund source National Nuclear Security Administration Grant No. DEFC03- 03NA00143, and under the Stewardship Science Academic Alliance program through DOE Cooperative Agreement No. DE-FG52-08NA28552 (UTK). A.A.C. acknowledges support by the Polish Ministry of Science and Higher Education through Grant No. 0079/DIA/2014/43 (”Grant Diamentowy”). H.S. acknowledges support by the US National Science Foundation under awards PHY-1430152 (JINA Center for the Evolution of the Elements) and PHY-1102511. P.S. acknowledges support from MCIU/AEI/FEDER_UE (Spain) under Grant No. PGC2018-093636-B-I00