Does heel height cause imbalance during sit-to-stand task: surface EMG perspective

© 2017 Naik, Al-Ani, Gobbo and Nguyen. The purpose of this study was to determine whether electromyography (EMG) muscle activities around the knee differ during sit-to-stand (STS) and returning task for females wearing shoes with different heel heights. Sixteen healthy young women (age = 25.2 ± 3.9 years, body mass index = 20.8 ± 2.7 kg/m2 ) participated in this study. Electromyography signals were recorded from the two muscles, vastus medialis (VM) and vastus lateralis (VL) that involve in the extension of knee. The participants wore shoes with five different heights, including 4, 6, 8, 10, and 12 cm. Surface electromyography (sEMG) data were acquired during STS and stand-to-sit-returning (STSR) tasks. The data was filtered using a fourth order Butterworth (band pass) filter of 20–450 Hz frequency range. For each heel height, we extracted median frequency (MDF) and root mean square (RMS) features to measure sEMG activities between VM and VL muscles. The experimental results (based on MDF and RMS-values) indicated that there is imbalance between vasti muscles for more elevated heels. The results are also quantified with statistical measures. The study findings suggest that there would be an increased likelihood of knee imbalance and fatigue with regular usage of high heel shoes (HHS) in women

Fast Transition between High-soft and Low-soft States in GRS 1915+105: Evidence for a Critically Viscous Accretion Flow

We present the results of a detailed analysis of RXTE observations of class $\omega$ which show an unusual state transition between high-soft and low-soft states in the microquasar GRS 1915+105. Out of about 600 pointed RXTE observations, the source was found to exhibit such state transition only on 16 occasions. An examination of the RXTE/ASM data in conjunction with the pointed observations reveals that these events appeared as a series of quasi-regular dips in two stretches of long duration (about 20 days during each occasions) when hard X-ray and radio flux were very low. The X-ray light curve and color-color diagram of the source during these observations are found to be different from any reported so far. The duration of these dips is found to be of the order of a few tens of seconds with a repetition time of a few hundred seconds. The transition between these dips and non-dips which differ in intensity by a factor of ~ 3.5, is observed to be very fast (~ a few seconds). It is observed that the low-frequency narrow QPOs are absent in the power density spectrum (PDS) of the dip and non-dip regions of class $\omega$ and the PDS is a power law in 0.1 - 10 Hz frequency range. There is a remarkable similarity in the spectral and timing properties of the source during the dip and non-dip regions in these set of observations. These properties of the source are distinctly different from those seen in the observations of other classes. This indicates that the basic accretion disk structure during both dip and non-dip regions of class $\omega$ is similar, but differ only in intensity. To explain these observations, we invoke a model in which the viscosity is very close to critical viscosity and the shock wave is weak or absent.Comment: Replaced with correct figures, Jour. of Astrophysics and Astronomy (accepted

FORMULATION AND EVALUATION OF BUOYANT TABLETS OF KETOCONAZOLE

Objective: The primary objective of the present work was to formulate the gastro-retentive delivery system of ketoconazole (ktz) for its extensive absorption in the stomach. Methods: The solubility and dissolution of antifungal ktz were reported to be higher in the stomach than in the intestinal pH conditions because of its dibasic pKa values 6.51 and 2.94. Thus the development of target buoyant tablets using Hydroxy Propyl Cellulose (HPC) and Xanthan gum (Xg) as polymers along with the effect of citric acid and sodium bicarbonate as an effervescent causing agent of floatation properties and drug release profile was investigated. The formulation optimization was carried out by using a central composite design using Design Expert software by taking HPC, Xanthan gum and sodium bicarbonate as independent variables and floating lag time, in vitro drug release profile as dependent variables respectively. Results: The optimized formulation of ktz buoyant tablets could be developed. The amount of HPC and Xg was found to significantly influence all in vitro response parameters. The results of pre-compression and post-compression parameters of all the formulations were found to be within the standard limits. The optimized formulation exhibited floating lag time of 160 secs with sustained drug release over a period of 12 h in simulated stomach pH condition. Conclusion: Buoyant tablets of ktz with sustained drug release over a period of 12 h in simulated stomach conditions for enhanced drug absorption could be successfully developed

Ferromagnetism at 300 K in spin-coated anatasea and rutile Ti0.95Fe0.05O2 films

Thin films of Ti1-xFexO2 (x=0 and 0.05) have been prepared on sapphire substrates by spin-on technique starting from metal organic precursors. When heat treated in air at 550 and 700 degrees C respectively, these films present pure anatase and rutile structures as shown both by X-ray diffraction and Raman spectroscopy. Optical absorption indicate a high degree of transparency in the visible region. Such films show a very small magnetic moment at 300 K. However, when the anatase and the rutile films are annealed in a vacuum of 1x10-5 Torr at 500 degrees C and 600 degrees C respectively, the magnetic moment, at 300 K, is strongly enhanced reaching 0.46 $\mu$B/Fe for the anatase sample and 0.48 $\mu$B/Fe for the rutile one. The ferromagnetic Curie temperature of these samples is above 350 K.Comment: 13 october 200

On the origin of the various types of radio emission in GRS 1915+105

We investigate the association between the radio ``plateau'' states and the large superluminal flares in GRS 1915+105 and propose a qualitative scenario to explain this association. We identify several candidate superluminal flare events from available monitoring data on this source and analyze the contemporaneous RXTE pointed observations. We detect a strong correlation between the average X-ray flux during the ``plateau'' state and the total energy emitted in radio during the subsequent radio flare. We find that the sequence of events is similar for all large radio flares with a fast rise and exponential decay morphology. Based on these results, we propose a qualitative scenario in which the separating ejecta during the superluminal flares are observed due to the interaction of the matter blob ejected during the X-ray soft dips, with the steady jet already established during the ``plateau'' state. This picture can explain all types of radio emission observed from this source in terms of its X-ray emission characteristics.Comment: Corrected typo in the author names, contents unchanged, accepted in Ap

Variants of fattening and flavor symmetry restoration

We study the effects of different "fat link" actions for Kogut-Susskind quarks on flavor symmetry breaking. Our method is mostly empirical - we compute the pion spectrum with different valence quark actions on common sets of sample lattices. Different actions are compared, as best we can, at equivalent physical points. We find significant reductions in flavor symmetry breaking relative to the conventional or to the "link plus staple" actions, with a reasonable cost in computer time. We also develop and test a scheme for approximate unitarization of the fat links. While our tests have concentrated on the valence quark action, our results will be useful in designing simulations with dynamical quarks.Comment: 16 pages, LaTeX, PostScript figures include

First determination of the CPCP content of D→π+π−π+π−D \to \pi^+\pi^-\pi^+\pi^- and updated determination of the CPCP contents of D→π+π−π0D \to \pi^+\pi^-\pi^0 and D→K+K−π0D \to K^+K^-\pi^0

Quantum-correlated $\psi(3770) \to D\bar{D}$ decays collected by the CLEO-c experiment are used to perform a first measurement of $F_+^{4\pi}$, the fractional $CP$-even content of the self-conjugate decay $D \to \pi^+\pi^-\pi^+\pi^-$, obtaining a value of $0.737 \pm 0.028$. An important input to the measurement comes from the use of $D \to K^0_{\rm S}\pi^+\pi^-$ and $D \to K^0_{\rm L}\pi^+\pi^-$ decays to tag the signal mode. This same technique is applied to the channels $D \to\pi^+\pi^-\pi^0$ and $D \to K^+K^-\pi^0$, yielding $F_+^{\pi\pi\pi^0} = 1.014 \pm 0.045 \pm 0.022$ and $F_+^{KK\pi^0} = 0.734 \pm 0.106 \pm 0.054$, where the first uncertainty is statistical and the second systematic. These measurements are consistent with those of an earlier analysis, based on $CP$-eigenstate tags, and can be combined to give values of $F_+^{\pi\pi\pi^0} = 0.973 \pm 0.017$ and $F_+^{KK\pi^0} = 0.732 \pm 0.055$. The results will enable the three modes to be included in a model-independent manner in measurements of the unitarity triangle angle $\gamma$ using $B^\mp \to DK^\mp$ decays, and in time-dependent studies of $CP$ violation and mixing in the $D\bar{D}$ system.Comment: Minor revisions following journal acceptanc

Probing the Kinetic Stabilities of Friedreich’s Ataxia Clinical Variants Using a Solid Phase GroEL Chaperonin Capture Platform

Numerous human diseases are caused by protein folding defects where the protein may become more susceptible to degradation or aggregation. Aberrant protein folding can affect the kinetic stability of the proteins even if these proteins appear to be soluble in vivo. Experimental discrimination between functional properly folded and misfolded nonfunctional conformers is not always straightforward at near physiological conditions. The differences in the kinetic behavior of two initially folded frataxin clinical variants were examined using a high affinity chaperonin kinetic trap approach at 25 °C. The kinetically stable wild type frataxin (FXN) shows no visible partitioning onto the chaperonin. In contrast, the clinical variants FXN-p.Asp122Tyr and FXN-p.Ile154Phe kinetically populate partial folded forms that tightly bind the GroEL chaperonin platform. The initially soluble FXN-p.Ile154Phe variant partitions onto GroEL more rapidly and is more kinetically liable. These differences in kinetic stability were confirmed using differential scanning fluorimetry. The kinetic and aggregation stability differences of these variants may lead to the distinct functional impairments described in Friedreich’s ataxia, the neurodegenerative disease associated to frataxin functional deficiency. This chaperonin platform approach may be useful for identifying small molecule stabilizers since stabilizing ligands to frataxin variants should lead to a concomitant decrease in chaperonin binding

Feshbach resonances in the 6Li-40K Fermi-Fermi mixture: Elastic versus inelastic interactions

We present a detailed theoretical and experimental study of Feshbach resonances in the 6Li-40K mixture. Particular attention is given to the inelastic scattering properties, which have not been considered before. As an important example, we thoroughly investigate both elastic and inelastic scattering properties of a resonance that occurs near 155 G. Our theoretical predictions based on a coupled channels calculation are found in excellent agreement with the experimental results. We also present theoretical results on the molecular state that underlies the 155G resonance, in particular concerning its lifetime against spontaneous dissociation. We then present a survey of resonances in the system, fully characterizing the corresponding elastic and inelastic scattering properties. This provides the essential information to identify optimum resonances for applications relying on interaction control in this Fermi-Fermi mixture.Comment: Submitted to EPJD, EuroQUAM special issues "Cold Quantum Matter - Achievements and Prospects", v2 with updated calibration of magnetic field (+4mG correction) and updated figures 4 and