^{63}Cu, ^{35}Cl, and ^{1}H NMR in the S=1/2 Kagom\'e Lattice ZnCu_{3}(OH)_{6}Cl_{2}

ZnCu$_{3}$(OH)$_{6}$Cl$_{2}$ ($S=1/2$) is a promising new candidate for an ideal Kagom\'e Heisenberg antiferromagnet, because there is no magnetic phase transition down to $\sim$50 mK. We investigated its local magnetic and lattice environments with NMR techniques. We demonstrate that the intrinsic local spin susceptibility {\it decreases} toward T=0, but that slow freezing of the lattice near $\sim$50 K, presumably associated with OH bonds, contributes to a large increase of local spin susceptibility and its distribution. Spin dynamics near T=0 obey a power-law behavior in high magnetic fields.Comment: Phys. Rev. Lett. (in press

Batti il tamburo e non avere paura.

Batti il tamburo e non aver paura è un verso di una poesia di Heinrich Heine, il maggiore poeta romantico tedesco (ebreo, contrario al pangermanesimo, morto esule a Parigi) che invita tutti al coraggio ed allo impegno, delineando un excursus tra parole chiave della filosofia della scienza e della matematica (in particolare, in Kant, Husserl e Hilbert), per ricavare i moniti alla Geomatica. Infatti questa è costituita da un insieme di discipline scientifiche e tecnologiche che possono offrire benefici al mondo ed alla società, ma causare danni gravi ed è compito dei ricercatori, tecnici, studenti ed operatori fare che scienza e tecnologia siano adoperate ai fini di pace, sviluppo e progresso, e non di guerra, abuso e dominio. Per quanto riguarda i tre studiosi, Kant è preso in considerazione, come geografo (storico e studioso della politica) e come filosofo della scienza e della morale (nelle prime due sue sintesi critiche, seppure della seconda solo brevemente). Husserl e Hilbert (nello ordine un filosofo di formazione matematica ed un matematico, attento a problemi di logica) sono presi in considerazione nelle loro ultime opere, rispettivamente sulla crisi delle scienze europee e sui fondamenti della matematica. Infatti questi due studiosi possono entrambi rappresentare insieme uno dei punti di arrivo delle possibili riletture kantiane e il segnavia per una ripartenza verso nuovi pensieri (rispettivamente la filosofia analitica della conoscenza ed il convenzionalismo critico della matematica)

TMDlib and TMDplotter: library and plotting tools for transverse-momentum-dependent parton distributions

Transverse-momentum-dependent distributions (TMDs) are central in high-energy physics from both theoretical and phenomenological points of view. In this manual we introduce the library, TMDlib, of fits and parameterisations for transverse-momentum-dependent parton distribution functions (TMD PDFs) and fragmentation functions (TMD FFs) together with an online plotting tool, TMDplotter. We provide a description of the program components and of the different physical frameworks the user can access via the available parameterisations.Comment: version 2, referring to TMDlib 1.0.2 - comments and references adde

Intracranial Pressure Monitoring in Infants and Young Children With Traumatic Brain Injury

OBJECTIVE: To examine the use of intracranial pressure monitors and treatment for elevated intracranial pressure in children 24 months old or younger with traumatic brain injury in North Carolina between April 2009 and March 2012 and compare this with a similar cohort recruited 2000-2001. DESIGN: Prospective, observational cohort study. SETTING: Twelve PICUs in North Carolina. PATIENTS: All children 24 months old or younger with traumatic brain injury, admitted to an included PICU. INTERVENTIONS: None. MEASUREMENT AND MAIN RESULTS: The use of intracranial pressure monitors and treatments for elevated intracranial pressure were evaluated in 238 children with traumatic brain injury. Intracranial pressure monitoring (risk ratio, 3.7; 95% CI, 1.5-9.3) and intracranial pressure therapies were more common in children with Glasgow Coma Scale less than or equal to 8 compared with Glasgow Coma Scale greater than 8. However, only 17% of children with Glasgow Coma Scale less than or equal to 8 received a monitoring device. Treatments for elevated intracranial pressure were more common in children with monitors; yet, some children without monitors received therapies traditionally used to lower intracranial pressure. Unadjusted predictors of monitoring were Glasgow Coma Scale less than or equal to 8, receipt of cardiopulmonary resuscitation, nonwhite race. Logistic regression showed no strong predictors of intracranial pressure monitor use. Compared with the 2000 cohort, children in the 2010 cohort with Glasgow Coma Scale less than or equal to 8 were less likely to receive monitoring (risk ratio, 0.5; 95% CI, 0.3-1.0), although the estimate was not precise, or intracranial pressure management therapies. CONCLUSION: Children in the 2010 cohort with a Glasgow Coma Scale less than or equal to 8 were less likely to receive an intracranial pressure monitor or hyperosmolar therapy than children in the 2000 cohort; however, about 10% of children without monitors received therapies to decrease intracranial pressure. This suggests treatment heterogeneity in children 24 months old or younger with traumatic brain injury and a need for better evidence to support treatment recommendations for this group of children

Spin chirality on a two-dimensional frustrated lattice

The collective behavior of interacting magnetic moments can be strongly influenced by the topology of the underlying lattice. In geometrically frustrated spin systems, interesting chiral correlations may develop that are related to the spin arrangement on triangular plaquettes. We report a study of the spin chirality on a two-dimensional geometrically frustrated lattice. Our new chemical synthesis methods allow us to produce large single crystal samples of KFe3(OH)6(SO4)2, an ideal Kagome lattice antiferromagnet. Combined thermodynamic and neutron scattering measurements reveal that the phase transition to the ordered ground-state is unusual. At low temperatures, application of a magnetic field induces a transition between states with different non-trivial spin-textures.Comment: 7 pages, 4 figure

Improved fertilization and implantation rates after non-touch zona pellucida microdrilling of mouse oocytes with a 1.48 μm diode laser beam

The safety of microdrilling the zona pellucida of moose oocytes with a 1.48 μm diode laser has been investigated by determining the ability of mouse oocytes to fertilize in vitro and develop in vivo. Mice born after transfer of control and zona pelludda-microdrilled embryos into foster mothers were submitted to anatomical and immunohisto-chemical investigations, and their aptitude to breed was assessed in two subsequent generations. Decolonization of the oocytes with hyaluronidase induced a reduction of the fertilization and implantation rates, which was attributed to a zona hardening phenomenon. After laser zona pellucida microdrilling, these rates were restored to those obtained with embryos derived from untreated oocyte-cumulus complexes. Pups derived from zona pellucida microdrilled embryos were comparable with those obtained from control embryos, confirming the lack of deleterious effects of the laser treatment In conclusion, the 1.48 μm diode laser allows safe microdrilling of the zona pellucida of mouse oocytes after decoronization with hyaluronidase. Based on the health of the F2 generation and the lack of neuroanatom-ical and neurochemical differences, we concluded that this technology may be investigated in the human, particularly when the zona pellucida represents the main impediment for fertilization or embryo hatchin

Dzyaloshinskii-Moriya interaction and spin re-orientation transition in the frustrated kagome lattice antiferromagnet

Magnetization, specific heat, and neutron scattering measurements were performed to study a magnetic transition in jarosite, a spin-5/2 kagome lattice antiferromagnet. When a magnetic field is applied perpendicular to the kagome plane, magnetizations in the ordered state show a sudden increase at a critical field H_c, indicative of the transition from antiferromagnetic to ferromagnetic states. This sudden increase arises as the spins on alternate kagome planes rotate 180 degrees to ferromagnetically align the canted moments along the field direction. The canted moment on a single kagome plane is a result of the Dzyaloshinskii-Moriya interaction. For H < H_c, the weak ferromagnetic interlayer coupling forces the spins to align in such an arrangement that the canted components on any two adjacent layers are equal and opposite, yielding a zero net magnetic moment. For H > H_c, the Zeeman energy overcomes the interlayer coupling causing the spins on the alternate layers to rotate, aligning the canted moments along the field direction. Neutron scattering measurements provide the first direct evidence of this 180-degree spin rotation at the transition.Comment: 13 pages, 15 figure

In situ microfluidic cryofixation for cryo Focused Ion Beam milling and cryo electron tomography.

We present a microfluidic platform for studying structure-function relationships at the cellular level by connecting video rate live cell imaging with in situ microfluidic cryofixation and cryo-electron tomography of near natively preserved, unstained specimens. Correlative light and electron microscopy (CLEM) has been limited by the time required to transfer live cells from the light microscope to dedicated cryofixation instruments, such as a plunge freezer or high-pressure freezer. We recently demonstrated a microfluidic based approach that enables sample cryofixation directly in the light microscope with millisecond time resolution, a speed improvement of up to three orders of magnitude. Here we show that this cryofixation method can be combined with cryo-electron tomography (cryo-ET) by using Focused Ion Beam milling at cryogenic temperatures (cryo-FIB) to prepare frozen hydrated electron transparent sections. To make cryo-FIB sectioning of rapidly frozen microfluidic channels achievable, we developed a sacrificial layer technique to fabricate microfluidic devices with a PDMS bottom wall <5 µm thick. We demonstrate the complete workflow by rapidly cryo-freezing Caenorhabditis elegans roundworms L1 larvae during live imaging in the light microscope, followed by cryo-FIB milling and lift out to produce thin, electron transparent sections for cryo-ET imaging. Cryo-ET analysis of initial results show that the structural preservation of the cryofixed C. elegans was suitable for high resolution cryo-ET work. The combination of cryofixation during live imaging enabled by microfluidic cryofixation with the molecular resolution capabilities of cryo-ET offers an exciting avenue to further advance space-time correlative light and electron microscopy (st-CLEM) for investigation of biological processes at high resolution in four dimensions