Patient-Specific Neurovascular Simulator for Evaluating the Performance of Medical Robots and Instrumens

Proceedings of the 2006 IEEE International Conference on Robotics and Automation, Orlando, Florida, May 200

Severe myoclonic epilepsy in infancy: evolution of seizures

Changes in seizure type of severe myoclonic epilepsy (SME) in infancy were reviewed retrospectively in 14 patients (11 males and 3 females) who were followed-up to the age of 7 years or more. The observation period ranged from 5 to 16 years with a mean of 10 years. During the follow-up, three or four types of seizures were seen per patient, but the pattern of appearance and disappearance of each seizure type varied considerably among the patients. Tonic-clonic convulsion, either generalized or unilateral, was seen most consistently through the entire course, and it continued to the end of follow-up in 11 patients (79%). On the contrary, myoclonic seizure, complex partial seizure, and atypical absence often disappeared and reappeared repeatedly during the course. In SME, seizure symptoms varied widely among patients in comparison with other neurological symptoms, and the most consistent core seizure type was tonic-clonic convulsions

The X-ray CCD camera of the MAXI Experiment on the ISS/JEM

MAXI, Monitor of All-sky X-ray Image, is the X-ray observatory on the Japanese experimental module (JEM) Exposed Facility (EF) on the International Space Station (ISS). MAXI is a slit scanning camera which consists of two kinds of X-ray detectors: one is a one-dimensional position-sensitive proportional counter with a total area of $\sim 5000 cm^2$, the Gas Slit Camera (GSC), and the other is an X-ray CCD array with a total area $\sim 200 cm^2$, the Solid-state Slit Camera (SSC). The GSC subtends a field of view with an angular dimension of 1$^\circ\times 180^\circ$ while the SSC subtends a field of view with an angular dimension of 1$^\circ$ times a little less than 180$^\circ$. In the course of one station orbit, MAXI can scan almost the entire sky with a precision of 1$^\circ$ and with an X-ray energy range of 0.5-30 keV. We have developed the engineering model of CCD chips and the analogue electronics for the SSC. The energy resolution of EM CCD for Mn K$\alpha$ has a full-width at half maximum of $\simeq$ 182 eV. Readout noise is $\simeq$ 11 e^- rms.Comment: 10 pages, 4 figures Accepted for Nuclear Instruments and Method in Physics Researc

A contribution of stellar flares to the GRXE -- based on MAXI observations --

Using unbiased observations of MAXI/GSC the potential contribution of stellar flares and CVs to GRXE luminosity is estimated in the energy range of 2 - 10 keV. Currently, a reasonable luminosity has been obtained extrapolating the number of stellar flares and that of CVs toward the Galactic ridge from those of the observed flares and CVs near the solar system. The ionized emission lines of Si to Fe are also simulated making the composite thermal spectrum which is based on MAXI observations of stellar flares and CVs. The present estimated result strongly supports a picture that the cumulative stellar flares contribute primarily to the GRXE in terms of the composite thermal spectrum with emission lines and secondary contribution is due to the thermal spectrum with high temperature from CVs

Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes

Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing