Investigating root architectural differences in lines of Arabidopsis thaliana. L. with altered stomatal density using high resolution X-Ray synchrotron imaging

Purpose Freshwater is an increasingly scarce natural resource, essential for agricultural production. As plants consume 70% of the world’s freshwater, a reduction in their water use would greatly reduce global water scarcity. Plants with improved Water Use Efficiency (WUE) such as those with altered expression of the Epidermal Patterning Factor (EPF) family of genes regulating stomatal density, could help reduce plant water footprint. Little however, is known about how this modification in Arabidopsis thaliana. L. affects root architectural development in soil, thus we aim to improve our understanding of root growth when stomatal density is altered. Methods We used X-Ray synchrotron and neutron imaging to measure in three dimensions, the root system architecture (RSA) of Arabidopsis thaliana. L. plants of three different genotypes, namely that of the wild type Columbia (Col 0) and two different EPF mutants, EPF2OE and epf2-1 (which show reduced and increased stomatal density, respectively). We also used the total biomass and carbon isotope discrimination (Δ) methods to determine how WUE varies in these genotypes when grown in a sandy loam soil under controlled conditions. Results Our results confirm that the EPF2OE line had superior WUE as compared to the wild type using both the Δ and total biomass method. The epf2-1 mutant, on the other hand, had significantly reduced WUE using the Δ but not with the biomass method. In terms of root growth, the RSAs of the different genotypes had no significant difference between each other. There was also no significant difference in rhizosphere porosity around their roots as compared to bulk soil for all genotypes. Conclusion Our results indicate that the EPF mutation altering stomatal density in Arabidopsis thaliana. L. plants did not have an adverse effect on root characteristics thus their wide adoption to reduce the global freshwater footprint is unlikely to compromise their soil foraging ability

Comparison of quality-of-care measures in U.S. patients with end-stage renal disease secondary to lupus nephritis vs. other causes

BACKGROUND: Patients with end-stage renal disease (ESRD) due to lupus nephritis (LN-ESRD) may be followed by multiple providers (nephrologists and rheumatologists) and have greater opportunities to receive recommended ESRD-related care. We aimed to examine whether LN-ESRD patients have better quality of ESRD care compared to other ESRD patients. METHODS: Among incident patients (7/05–9/11) with ESRD due to LN (n = 6,594) vs. other causes (n = 617,758), identified using a national surveillance cohort (United States Renal Data System), we determined the association between attributed cause of ESRD and quality-of-care measures (pre-ESRD nephrology care, placement on the deceased donor kidney transplant waitlist, and placement of permanent vascular access). Multivariable logistic and Cox proportional hazards models were used to estimate adjusted odds ratios (ORs) and hazard ratios (HRs). RESULTS: LN-ESRD patients were more likely than other ESRD patients to receive pre-ESRD care (71% vs. 66%; OR = 1.68, 95% CI 1.57-1.78) and be placed on the transplant waitlist in the first year (206 vs. 86 per 1000 patient-years; HR = 1.42, 95% CI 1.34–1.52). However, only 24% had a permanent vascular access (fistula or graft) in place at dialysis start (vs. 36%; OR = 0.63, 95% CI 0.59–0.67). CONCLUSIONS: LN-ESRD patients are more likely to receive pre-ESRD care and have better access to transplant, but are less likely to have a permanent vascular access for dialysis, than other ESRD patients. Further studies are warranted to examine barriers to permanent vascular access placement, as well as morbidity and mortality associated with temporary access, in patients with LN-ESRD

Unlocking the Potential of Fish to Improve Food and Nutrition Security in Sub-Saharan Africa

Approximately one-third of the global population suffering from chronic hunger are in sub-Saharan Africa (SSA). In addition to high prevalence of chronic hunger, millions of people suffer from micronutrient deficiencies. Meanwhile, there is growing consensus across scientific disciplines concurring that fish plays a crucial role in improving food and nutrition security. Therefore, the present review aims to demonstrate the role of fish and the whole fisheries sector towards securing food and nutrition security in SSA by summarizing the existing literature. Fish is a treasure store of animal protein and essential micronutrients such as zinc, iodine, calcium, and vitamins, which are essential in human nutrition and have proven to help reduce the risks of both malnutrition and non-communicable diseases. Policymakers, development agencies, and society should recognize the role that the fisheries sector can play in combatting hunger and undernutrition, especially for the poor and marginalized people in SSA

Unlocking the Potential of Fish to Improve Food and Nutrition Security in Sub-Saharan Africa

Approximately one-third of the global population suffering from chronic hunger are in sub-Saharan Africa (SSA). In addition to high prevalence of chronic hunger, millions of people suffer from micronutrient deficiencies. Meanwhile, there is growing consensus across scientific disciplines concurring that fish plays a crucial role in improving food and nutrition security. Therefore, the present review aims to demonstrate the role of fish and the whole fisheries sector towards securing food and nutrition security in SSA by summarizing the existing literature. Fish is a treasure store of animal protein and essential micronutrients such as zinc, iodine, calcium, and vitamins, which are essential in human nutrition and have proven to help reduce the risks of both malnutrition and non-communicable diseases. Policymakers, development agencies, and society should recognize the role that the fisheries sector can play in combatting hunger and undernutrition, especially for the poor and marginalized people in SSA