Evolution of transport under cumulative damage in metro systems

One dominant aspect of cities is transport and massive passenger mobilization which remains a challenge with the increasing demand on the public as cities grow. In addition, public transport infrastructure suffers from traffic congestion and deterioration, reducing its efficiency. In this paper, we study the capacity of transport in 33 worldwide metro systems under the accumulation of damage. We explore the gradual reduction of functionality in these systems associated with damage that occurs stochastically. The global transport of each network is modeled as the diffusive movement of Markovian random walkers on networks considering the capacity of transport of each link, where these links are susceptible to damage. Monte Carlo simulations of this process in metro networks show the evolution of the functionality of the system under damage considering all the complexity in the transportation structure. This information allows us to compare and classify the effect of damage in metro systems. Our findings provide a general framework for the characterization of the capacity to maintain the transport under failure in different systems described by networks.Comment: 9 pages; 4 figure

Relations de dispersion pour des chaînes linéaire comportant des interactions harmoniques auto-similaires

Many systems in nature have arborescent and bifurcated structures such as trees, fern, snails, lungs, the blood vessel system, etc. and look self-similar over a wide range of scales. Which are the mechanical and dynamic properties that evolution has optimized by choosing self-similarity? How can we describe the mechanics of self-similar structures in the static and dynamic framework? Physical systems with self-similarity as a symmetry property require the introduction of non-local particle-particle interactions and a (quasi-) continuous distribution of mass. We construct self-similar functions and linear operators such as a self-similar variant of the Laplacian and of the D'Alembertian wave operator. The obtained self-similar linear wave equation describes the dynamics of a quasi-continuous linear chain of infinite length with a spatially self-similar distribution of nonlocal inter-particle springs. The self-similarity of the nonlocal harmonic particle-particle interactions results in a dispersion relation of the form of a Weierstrass-Mandelbrot function which exhibits self-similar and fractal features. We deduce a continuum approximation that links the self-similar Laplacian to fractional integrals and which yields in the low-frequency regime a power law frequency dependence for the oscillator density. For details of the present model we refer to our recent paper (Michelitsch et al., Phys. Rev. E 80, 011135 (2009))

Influence of supplementary cementitious materials on water transport kinetics and mechanical properties of hydrated lime and cement mortars

The purpose of this paper is an investigation of the possible role of supplementary cementitious materials (SCMs) on water transport kinetics and mechanical properties of hydrated lime (CL90) and Portland cement (PC) mortars. The properties of hydrated lime are significantly different from those of cement and therefore modifying fresh and hardened properties of these mortars are vital for mortar/substrate optimisation in masonry construction. The parameters investigated in this paper often are the main barriers to the use of hydrated lime in construction practice. The results show that transfer sorptivity and time to dewater freshly-mixed hydrated lime mortars can be modified when binder is partially replaced with SCMs. Compressive strength of CL90 mortars is increased systematically with the increased replacement levels of SCMs and the results are supported with the microstructural images. The ability to modify the water transport kinetics and mechanical properties allows compatibility between the mortar and the substrate unit in masonry construction.<br><br>El objetivo de este artículo es investigar el papel de los materiales cementantes suplementarios (SCMs) en la cinética de transporte del agua y en las propiedades mecánicas de los morteros de cal hidratada (CL90) y cemento Portland. Las propiedades de la cal hidratada son significativamente diferentes a las del cemento y por lo tanto el control de las propiedades de los morteros frescos y endurecidos es fundamental en la optimización mortero/substrato en albañilería. Los parámetros estudiados en este trabajo son a menudo las principales barreras para el uso de la cal hidratada en la práctica de la construcción. Los resultados indican que la absortividad y el tiempo necesario para deshidratar morteros de cal hidratada recién mezclados pueden ser controlados cuando el conglomerante es parcialmente remplazado por SCMs. La resistencia a compresión de los morteros CL90 aumenta sistemáticamente con el nivel de sustitución de SCM. Las imágenes microestructurales realizadas, confirman estos resultados. La posibilidad de manipular la cinética de transporte de agua y las propiedades mecánicas permite la compatibilidad entre el mortero y la unidad de sustrato en albañilería

The Schizosaccharomyces pombe Hsp104 Disaggregase Is Unable to Propagate the [PSI+] Prion

The molecular chaperone Hsp104 is a crucial factor in the acquisition of thermotolerance in yeast. Under stress conditions, the disaggregase activity of Hsp104 facilitates the reactivation of misfolded proteins. Hsp104 is also involved in the propagation of fungal prions. For instance, the well-characterized [PSI+] prion of Saccharomyces cerevisiae does not propagate in Δhsp104 cells or in cells overexpressing Hsp104. In this study, we characterized the functional homolog of Hsp104 from Schizosaccharomyces pombe (Sp_Hsp104). As its S. cerevisiae counterpart, Sp_hsp104+ is heat-inducible and required for thermotolerance in S. pombe. Sp_Hsp104 displays low disaggregase activity and cannot propagate the [PSI+] prion in S. cerevisiae. When overexpressed in S. cerevisiae, Sp_Hsp104 confers thermotolerance to Δhsp104 cells and reactivates heat-aggregated proteins. However, overexpression of Sp_Hsp104 does not propagate nor eliminate [PSI+]. Strikingly, [PSI+] was cured by overexpression of a chimeric chaperone bearing the C-terminal domain (CTD) of the S. cerevisiae Hsp104 protein. Our study demonstrates that the ability to untangle aggregated proteins is conserved between the S. pombe and S. cerevisiae Hsp104 homologs, and points to a role of the CTD in the propagation of the S. cerevisiae [PSI+] prion

Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+]

Prions are proteins that can access multiple conformations, at least one of which is beta-sheet rich, infectious and self-perpetuating in nature. These infectious proteins show several remarkable biological activities, including the ability to form multiple infectious prion conformations, also known as strains or variants, encoding unique biological phenotypes, and to establish and overcome prion species (transmission) barriers. In this Perspective, we highlight recent studies of the yeast prion [PSI+], using various biochemical and structural methods, that have begun to illuminate the molecular mechanisms by which self-perpetuating prions encipher such biological activities. We also discuss several aspects of prion conformational change and structure that remain either unknown or controversial, and we propose approaches to accelerate the understanding of these enigmatic, infectious conformers