Suppression of Shot Noise in Quantum Point Contacts in the "0.7" Regime

Experimental investigations of current shot noise in quantum point contacts show a reduction of the noise near the 0.7 anomaly. It is demonstrated that such a reduction naturally arises in a model proposed recently to explain the characteristics of the 0.7 anomaly in quantum point contacts in terms of a quasi-bound state, due to the emergence of two conducting channels. We calculate the shot noise as a function of temperature, applied voltage and magnetic field, and demonstrate an excellent agreement with experiments. It is predicted that with decreasing temperature, voltage and magnetic field, the dip in the shot noise is suppressed due to the Kondo effect.Comment: 4 pages, 1 figur

Tunneling Spectroscopy of Disordered Two-Dimensional Electron Gas in the Quantum Hall Regime

Recently, Dial et al. presented measurements of the tunneling density of states into the bulk of a two dimensional electron gas under strong magnetic fields. Several high energy features appear in the measured spectrum showing a distinct dependence on filling factor and a unique response to temperature. We present a quantitative account of the observed structure, and argue it results from the repulsive Coulomb interactions between the tunneling electron and states localized at disorder potential wells. The quenching of the kinetic energy by the applied magnetic field leads to an electron addition spectrum that is primarily determined by the external magnetic field and is nearly independent of the disorder potential. Using a Hartree-Fock model we reproduce the salient features of the observed structure

Andreev Tunneling in Strongly Interacting Quantum Dots

We review recent work on resonant Andreev tunneling through a strongly interacting quantum dot connected to a normal and to a superconducting lead. We derive a general expression for the current flowing in the structure and discuss the linear and non-linear transport in the nonperturbative regime. New effects associated to the Kondo resonance combined with the two-particle tunneling arise. The Kondo anomaly in the $I-V$ characteristics depends on the relative size of the gap energy and the Kondo temperature.Comment: 8 pages, 4 figures; submitted to Superlattices and Microstructure

A simple stochastic model for the evolution of protein lengths

We analyse a simple discrete-time stochastic process for the theoretical modeling of the evolution of protein lengths. At every step of the process a new protein is produced as a modification of one of the proteins already existing and its length is assumed to be random variable which depends only on the length of the originating protein. Thus a Random Recursive Trees (RRT) is produced over the natural integers. If (quasi) scale invariance is assumed, the length distribution in a single history tends to a lognormal form with a specific signature of the deviations from exact gaussianity. Comparison with the very large SIMAP protein database shows good agreement.Comment: 12 pages, 4 figure

Adenoid cystic carcinoma: emerging role of translocations and gene fusions.

Adenoid cystic carcinoma (ACC), the second most common salivary gland malignancy, is notorious for poor prognosis, which reflects the propensity of ACC to progress to clinically advanced metastatic disease. Due to high long-term mortality and lack of effective systemic treatment, the slow-growing but aggressive ACC poses a particular challenge in head and neck oncology. Despite the advancements in cancer genomics, up until recently relatively few genetic alterations critical to the ACC development have been recognized. Although the specific chromosomal translocations resulting in MYB-NFIB fusions provide insight into the ACC pathogenesis and represent attractive diagnostic and therapeutic targets, their clinical significance is unclear, and a substantial subset of ACCs do not harbor the MYB-NFIB translocation. Strategies based on detection of newly described genetic events (such as MYB activating super-enhancer translocations and alterations affecting another member of MYB transcription factor family-MYBL1) offer new hope for improved risk assessment, therapeutic intervention and tumor surveillance. However, the impact of these approaches is still limited by an incomplete understanding of the ACC biology, and the manner by which these alterations initiate and drive ACC remains to be delineated. This manuscript summarizes the current status of gene fusions and other driver genetic alterations in ACC pathogenesis and discusses new therapeutic strategies stemming from the current research

Evidence for localization and 0.7 anomaly in hole quantum point contacts

Quantum point contacts implemented in p-type GaAs/AlGaAs heterostructures are investigated by low-temperature electrical conductance spectroscopy measurements. Besides one-dimensional conductance quantization in units of $2e^{2}/h$ a pronounced extra plateau is found at about $0.7(2e^{2}/h)$ which possesses the characteristic properties of the so-called "0.7 anomaly" known from experiments with n-type samples. The evolution of the 0.7 plateau in high perpendicular magnetic field reveals the existence of a quasi-localized state and supports the explanation of the 0.7 anomaly based on self-consistent charge localization. These observations are robust when lateral electrical fields are applied which shift the relative position of the electron wavefunction in the quantum point contact, testifying to the intrinsic nature of the underlying physics.Comment: 4.2 pages, 3 figure

Origins of conductance anomalies in a p-type GaAs quantum point contact

Low temperature transport measurements on a p-GaAs quantum point contact are presented which reveal the presence of a conductance anomaly that is markedly different from the conventional `0.7 anomaly'. A lateral shift by asymmetric gating of the conducting channel is utilized to identify and separate different conductance anomalies of local and generic origins experimentally. While the more generic 0.7 anomaly is not directly affected by changing the gate configuration, a model is proposed which attributes the additional conductance features to a gate-dependent coupling of the propagating states to localized states emerging due to a nearby potential imperfection. Finite bias conductivity measurements reveal the interplay between the two anomalies consistently with a two-impurity Kondo model