Both a single sacral marker and the whole-body center of mass accurately estimate peak vertical ground reaction force in running.

While running, the human body absorbs repetitive shocks with every step. These shocks can be quantified by the peak vertical ground reaction force (F <sub>v,max</sub> ). To measure so, using a force plate is the gold standard method (GSM), but not always at hand. In this case, a motion capture system might be an alternative if it accurately estimates F <sub>v,max</sub> . The purpose of this study was to estimate F <sub>v,max</sub> based on motion capture data and validate the obtained estimates with force plate-based measures. One hundred and fifteen runners participated at this study and ran at 9, 11, and 13 km/h. Force data (1000 Hz) and whole-body kinematics (200 Hz) were acquired with an instrumented treadmill and an optoelectronic system, respectively. The vertical ground reaction force was reconstructed from either the whole-body center of mass (COM-M) or sacral marker (SACR-M) accelerations, calculated as the second derivative of their respective positions, and further low-pass filtered using several cutoff frequencies (2-20 Hz) and a fourth-order Butterworth filter. The most accurate estimations of F <sub>v,max</sub> were obtained using 5 and 4 Hz cutoff frequencies for the filtering of COM and sacral marker accelerations, respectively. GSM, COM-M, and SACR-M were not significantly different at 11 km/h but were at 9 and 13 km/h. The comparison between GSM and COM-M or SACR-M for each speed depicted root mean square error (RMSE) smaller or equal to 0.17BW (≤6.5 %) and no systematic bias at 11 km/h but small systematic biases at 9 and 13 km/h (≤0.09 BW). COM-M gave systematic biases three times smaller than SACR-M and two times smaller RMSE. The findings of this study support the use of either COM-M or SACR-M using data filtered at 5 and 4 Hz, respectively, to estimate F <sub>v,max</sub> during level treadmill runs at endurance speeds

PENGHITUNGAN LAJU LUAS AREA HUTAN BERBASIS ALGORITMA SEGMENTASI WARNA LOKAL

Penelitian ini bertujuan menghitung laju perubahan (penambahan atau pengurangan) luas area hutan. Tahapan kegiatan yang dilakukan meliputi pencuplikan pikselwarna referensi hutan, transformasi warna dari RGBke dalam ruang warna HSV, ekstraksi dan segmentasi berbasis warna melalui disimilaritas jarak warna pada jendela partisi, proses binerisasi dan penelusuran tepi objek melalui rantai Freeman yang dilanjutkan penghitungan jumlah objek dan luas area objek keseluruhan. Hasilpenghitungan luas objek pada suatu periode dibandingkan dengan penghitungan luas objek pada periode lain. Penelitian ini dapat dimanfaatkan oleh instansi terkait untuk pemantauan luas hutan dan menjadi masukan bagi pengambilan keputusan untuk pengelolaan inventory hutan

A Single Sacral-Mounted Inertial Measurement Unit to Estimate Peak Vertical Ground Reaction Force, Contact Time, and Flight Time in Running.

Peak vertical ground reaction force (Fz,max), contact time (tc), and flight time (tf) are key variables of running biomechanics. The gold standard method (GSM) to measure these variables is a force plate. However, a force plate is not always at hand and not very portable overground. In such situation, the vertical acceleration signal recorded by an inertial measurement unit (IMU) might be used to estimate Fz,max, tc, and tf. Hence, the first purpose of this study was to propose a method that used data recorded by a single sacral-mounted IMU (IMU method: IMUM) to estimate Fz,max. The second aim of this study was to estimate tc and tf using the same IMU data. The vertical acceleration threshold of an already existing IMUM was modified to detect foot-strike and toe-off events instead of effective foot-strike and toe-off events. Thus, tc and tf estimations were obtained instead of effective contact and flight time estimations. One hundred runners ran at 9, 11, and 13 km/h. IMU data (208 Hz) and force data (200 Hz) were acquired by a sacral-mounted IMU and an instrumented treadmill, respectively. The errors obtained when comparing Fz,max, tc, and tf estimated using the IMUM to Fz,max, tc, and tf measured using the GSM were comparable to the errors obtained using previously published methods. In fact, a root mean square error (RMSE) of 0.15 BW (6%) was obtained for Fz,max while a RMSE of 20 ms was reported for both tc and tf (8% and 18%, respectively). Moreover, even though small systematic biases of 0.07 BW for Fz,max and 13 ms for tc and tf were reported, the RMSEs were smaller than the smallest real differences [Fz,max: 0.28 BW (11%), tc: 32.0 ms (13%), and tf: 32.0 ms (30%)], indicating no clinically important difference between the GSM and IMUM. Therefore, these results support the use of the IMUM to estimate Fz,max, tc, and tf for level treadmill runs at low running speeds, especially because an IMU has the advantage to be low-cost and portable and therefore seems very practical for coaches and healthcare professionals

Accurate estimation of peak vertical ground reaction force using the duty factor in level treadmill running.

This study aimed to 1) construct a statistical model (SMM) based on the duty factor (DF) to estimate the peak vertical ground reaction force (F <sub>v,max</sub> ) and 2) to compare the estimated F <sub>v,max</sub> to force plate gold standard (GSM). One hundred and fifteen runners ran at 9, 11, and 13km/h. Force (1000Hz) and kinematic (200Hz) data were acquired with an instrumented treadmill and an optoelectronic system, respectively, to assess force-plate and kinematic based DFs. SMM linearly relates F <sub>v,max</sub> to the inverse of DF because DF was analytically associated to the inverse of the average vertical force during ground contact time and the latter was very highly correlated to F <sub>v,max</sub> . No systematic bias and a 4% root mean square error (RMSE) were reported between GSM and SMM using force-plate based DF values when considering all running speeds together. Using kinematic based DF values, SMM reported a systematic but small bias (0.05BW) and a 5% RMSE when considering all running speeds together. These findings support the use of SMM to estimate F <sub>v,max</sub> during level treadmill runs at endurance speeds if underlying DF values are accurately measured

Does Characterizing Global Running Pattern Help to Prescribe Individualized Strength Training in Recreational Runners?

This study aimed to determine if concurrent endurance and strength training that matches the global running pattern would be more effective in increasing running economy (RE) than non-matched training. The global running pattern of 37 recreational runners was determined using the Volodalen <sup>®</sup> method as being aerial (AER) or terrestrial (TER). Strength training consisted of endurance running training and either plyometric (PLY) or dynamic weight training (DWT). Runners were randomly assigned to a matched (n = 18; DWT for TER, PLY for AER) or non-matched (n = 19; DWT for AER, PLY for TER) 8 weeks concurrent training program. RE, maximal oxygen uptake V̇O <sub>2</sub> max) and peak treadmill speed at V̇O <sub>2</sub> max (PTS) were measured before and after the training intervention. None of the tested performance related variables depicted a significant group effect or interaction effect between training and grouping (p ≥ 0.436). However, a significant increase in RE, V̇O <sub>2</sub> max, and PTS (p ≤ 0.003) was found after the training intervention. No difference in number of responders between matched and non-matched groups was observed for any of the performance related variables (p ≥ 0.248). In recreational runners, prescribing PLT or DWT according to the global running pattern of individuals, in addition to endurance training, did not lead to greater improvements in RE

What happened to anti-malarial markets after the Affordable Medicines Facility-malaria pilot? Trends in ACT availability, price and market share from five African countries under continuation of the private sector co-payment mechanism

BACKGROUND: The private sector supplies anti-malarial treatment for large proportions of patients in sub-Saharan Africa. Following the large-scale piloting of the Affordable Medicines Facility-malaria (AMFm) from 2010 to 2011, a private sector co-payment mechanism (CPM) provided continuation of private sector subsidies for quality-assured artemisinin combination therapies (QAACT). This article analyses for the first time the extent to which improvements in private sector QAACT supply and distribution observed during the AMFm were maintained or intensified during continuation of the CPM through 2015 in Kenya, Madagascar, Nigeria, Tanzania and Uganda using repeat cross-sectional outlet survey data. RESULTS: QAACT market share in all five countries increased during the AMFm period (p < 0.001). According to the data from the last ACTwatch survey round, in all study countries except Madagascar, AMFm levels of private sector QAACT availability were maintained or improved. In 2014/15, private sector QAACT availability was greater than 70% in Nigeria (84.3%), Kenya (70.5%), Tanzania (83.0%) and Uganda (77.1%), but only 11.2% in Madagascar. QAACT market share was maintained or improved post-AMFm in Nigeria, Tanzania and Uganda, but statistically significant declines were observed in Kenya and Madagascar. In 2014/5, QAACT market share was highest in Kenya and Uganda (48.2 and 47.5%, respectively) followed by Tanzania (39.2%), Nigeria (35.0%), and Madagascar (7.0%). Four of the five countries experienced significant decreases in median QAACT price during the AMFm period. Private sector QAACT prices were maintained or further reduced in Tanzania, Nigeria and Uganda, but prices increased significantly in Kenya and Madagascar. SP prices were consistently lower than those of QAACT in the AMFm period, with the exception of Kenya and Tanzania in 2011, where they were equal. In 2014/5 QAACT remained two to three times more expensive than the most popular non-artemisinin therapy in all countries except Tanzania. CONCLUSIONS: Results suggest that a private sector co-payment mechanism for QAACT implemented at national scale for 5 years was associated with positive and sustained improvements in QAACT availability, price and market share in Nigeria, Tanzania and Uganda, with more mixed results in Kenya, and few improvements in Madagascar. The subsidy mechanism as implemented over time across countries was not sufficient on its own to achieve optimal QAACT uptake. Supporting interventions to address continued availability and distribution of non-artemisinin therapies, and to create demand for QAACT among providers and consumers need to be effectively implemented to realize the full potential of this subsidy mechanism. Furthermore, there is need for comprehensive market assessments to identify contemporary market barriers to high coverage with both confirmatory testing and appropriate treatment

Predictors of Bacterial Meningitis in Resource-Limited Contexts: An Angolan Case

BACKGROUND: Despite the great morbidity and mortality that childhood bacterial meningitis (BM) is experiencing in Africa, diagnosis of BM in resource-limited contexts is still a challenge. Several algorithms and clinical predictors have been proposed to help physicians in decision-making but a lot of these markers used variables that are calculable only in well-equipped laboratories. Predictors or algorithm based on parameters that can be easily performed in basic laboratories can help significantly in BM diagnosis, even in resource-limited settings, rural hospitals or health centers. RESULTS: This retrospective study examined 145 cerebral-spinal fluid (CSF) specimens from children from 2 months to 14 years. CSF specimens were divided into two groups, according to the presence or not of a clinical diagnosis of BM. For each specimen, CSF aspect, CSF white blood cells (WBC) count, CSF glucose and protein concentration were analyzed and statistical analysis were performed. CSF WBC count ≥10/µl is no more a valuable predictor of BM. CSF protein concentration ≥50 mg/dl has a better sensitivity for BM diagnosis and when used with CSF glucose concentration ≤40 mg/dl, can help to diagnose correctly almost all the BM cases. An algorithm including CSF protein concentration, glucose concentration and WBC count has been proposed to rule out BM and to correctly diagnose it. CONCLUSIONS: In resource-limited health centers, the availability of a combination of easy-to-obtain parameters can significantly help physicians in BM diagnosis. The prompt identification of a BM case can be rapid treated or transferred to adequate structures and can modify the outcome in the patient

How Contemporary Human Reproductive Behaviors Influence the Role of Fertility-Related Genes: The Example of the P53 Gene

Studies on human fertility genes have identified numerous risk/protective alleles involved in the occurrence of reproductive system diseases causing infertility or subfertility. Investigations we carried out in populations at natural fertility seem to suggest that the clinical relevance that some fertility genes are now acquiring depends on their interaction with contemporary reproductive behaviors (birth control, delayed childbearing, and spacing birth order, among others). In recent years, a new physiological role in human fertility regulation has emerged for the tumor- suppressor p53 gene (P53), and the P53 Arg72Pro polymorphism has been associated with recurrent implantation failure in humans. To lend support to our previous observations, we examined the impact of Arg72Pro polymorphism on fertility in two samples of Italian women not selected for impaired fertility but collected from populations with different (premodern and modern) reproductive behaviors. Among the women at near-natural fertility (n = 98), the P53 genotypes were not associated with different reproductive efficiency, whereas among those with modern reproductive behaviors (n = 68), the P53 genotypes were associated with different mean numbers of children [Pro/Pro = 0.75<Pro/Arg = 1.7<Arg/Arg = 2, (p = 0.056)] and a significant negative relationship between the number of children and P53 Pro allele frequencies (p = 0.028) was observed. These results are consistent with those of clinical studies reporting an association between the P53 Pro allele and recurrent implantation failure. By combining these findings with previous ones, we suggest here that some common variants of fertility genes may have become “detrimental” following exposure to modern reproductive patterns and might therefore be associated with reduced reproductive success. Set within an evolutionary framework, this change could lead to the selection of a set of gene variants fitter to current reproductive behaviors as the shift to later child-bearing age in developed countries