THEOLOGICAL PERSPECTIVES ON DEVELOPMENT: COMPARING ROMAN CATHOLIC, ECUMENICAL AND EVANGELICAL POSITIONS

Since the middle of the 20th century, Christian churches have been involved internationally in development activities. In recent years, international agencies and national governments have recognised the role of religions in international development. This article reviews theological views on international development. For this purpose, official documents of the Roman Catholic Church, the ecumenical movement and the World Evangelical Alliance/Lausanne Movement are compared regarding concepts of development and its role in the mission of the Church and views on the world and humankind, actions and actors of development and eschatology. The study finds wide agreement in many aspects, but also some differences between the theological traditions. It discusses theological aspects that are relevant for the praxis of Christian development work and identifies issues that may need further research

Crystallographic Structure of Truncated CCL21 and the Putative Sulfotyrosine-Binding Site

CCL21 chemokine binds the G protein-coupled receptor CCR7, aiding not only in immune response but also in cancer metastasis. Compared with other chemokines, CCL21 has a unique extended unstructured C-terminus that is truncated in some naturally occurring variants. We have determined the X-ray crystallographic structure of a truncated CCL21 (residues 1–79) lacking the extended C-terminus and identified, via two-dimensional nuclear magnetic resonance (NMR), a putative sulfotyrosine-binding site that may recognize such post-translationally modified tyrosine residues on the receptor. Compared to the previously determined NMR structure of full-length CCL21, the crystal structure presents new druggable binding hot spots resulting from an alternative N-loop conformation. In addition, whereas the previous NMR structure did not provide any structural information after residue 70, the C-terminus of the truncated CCL21, ordered up to Ala77 in our crystal structure, is placed near the N-loop and sulfotyrosine-binding site, indicating that the extended C-terminus of full-length CCL21 can interact with this important region for receptor binding. These observations suggest a potential origin for the autoinhibition of CCL21 activity that was recently described. The new crystal structure and binding hot spot analysis have important implications for the function of the CCL21 C-terminus and drug discovery

Fortschrittliche Robotersteurerungstechnik. Teilprojekte 1, 2, 3 und 4 Abschlussbericht

The report summarizes the results of four partial projects: (i) integration of robot control in cim systems, (ii) overallstructure and interfaces of robot control systems, (iii) movement control of future robot systems, (iv) interaction interfaces, operation and programming. The cim robot control is provided with MAP 3.0 and comprises the information flow from the instruction up to the movement control including diagnosis. The interaction of computer and robot systems has been manifested by means of a demonstrator. Data transfer and communication technique in the direct robot environment was realized in the solution BITBUS. Improvements in the movement control was achieved by rapid processing of sensor data, enlargement of sensor control funtionality, methods of axial load adaption, improvement of the dynamic properties of axial control circuits, collision-avoiding path planning and improved path accuracy. Solutions are described for central operation as well as for off-line programming of the robot. New sensor-programming tools are used for exact robot programming following the off-line programming. (WEN)Available from TIB Hannover: F97B759 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany)DEGerman