317 research outputs found
Atomic scale engines: Cars and wheels
We introduce a new approach to build microscopic engines on the atomic scale
that move translationally or rotationally and can perform useful functions such
as pulling of a cargo. Characteristic of these engines is the possibility to
determine dynamically the directionality of the motion. The approach is based
on the transformation of the fed energy to directed motion through a dynamical
competition between the intrinsic lengths of the moving object and the
supporting carrier.Comment: 4 pages, 3 figures (2 in color), Phys. Rev. Lett. (in print
Supramolecularly directed rotary motion in a photoresponsive receptor
Stimuli-controlled motion at the molecular level has fascinated chemists already for several decades. Taking inspiration from the myriad of dynamic and machine-like functions in nature, a number of strategies have been developed to control motion in purely synthetic systems. Unidirectional rotary motion, such as is observed in ATP synthase and other motor proteins, remains highly challenging to achieve. Current artificial molecular motor systems rely on intrinsic asymmetry or a specific sequence of chemical transformations. Here, we present an alternative design in which the rotation is directed by a chiral guest molecule, which is able to bind non-covalently to a light-responsive receptor. It is demonstrated that the rotary direction is governed by the guest chirality and hence, can be selected and changed at will. This feature offers unique control of directional rotation and will prove highly important in the further development of molecular machinery
Quantitative trait locus analysis of resistance to panicle blast in the rice cultivar Miyazakimochi
Modulation of porosity in a solid material enabled by bulk photoisomerization of an overcrowded alkene
FWN – Publicaties zonder aanstelling Universiteit Leide
Malaria pigment crystals as magnetic micro-rotors: Key for high-sensitivity diagnosis
The need to develop new methods for the high-sensitivity
diagnosis of malaria has initiated a global activity in medical
and interdisciplinary sciences. Most of the diverse variety of
emerging techniques are based on research-grade instruments,
sophisticated reagent-based assays or rely on expertise. Here,
we suggest an alternative optical methodology with an easy-to-
use and cost-effective instrumentation based on unique
properties of malaria pigment reported previously and determined
quantitatively in the present study. Malaria pigment, also
called hemozoin, is an insoluble microcrystalline form of heme.
These crystallites show remarkable magnetic and optical
anisotropy distinctly from any other components of blood. As a
consequence, they can simultaneously act as magnetically driven
micro-rotors and spinning polarizers in suspensions. These
properties can gain importance not only in malaria diagnosis and
therapies, where hemozoin is considered as drug target or immune
modulator, but also in the magnetic manipulation of cells and
tissues on the microscopic scale
Energy consumption in chemical fuel-driven self-assembly
Nature extensively exploits high-energy transient self-assembly structures that are able to perform work through a dissipative process. Often, self-assembly relies on the use of molecules as fuel that is consumed to drive thermodynamically unfavourable reactions away from equilibrium. Implementing this kind of non-equilibrium self-assembly process in synthetic systems is bound to profoundly impact the fields of chemistry, materials science and synthetic biology, leading to innovative dissipative structures able to convert and store chemical energy. Yet, despite increasing efforts, the basic principles underlying chemical fuel-driven dissipative self-assembly are often overlooked, generating confusion around the meaning and definition of scientific terms, which does not favour progress in the field. The scope of this Perspective is to bring closer together current experimental approaches and conceptual frameworks. From our analysis it also emerges that chemically fuelled dissipative processes may have played a crucial role in evolutionary processes
Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8)
- …