279 research outputs found
Dynamical evolution of high velocity clouds in the intergalactic medium
HI observations of high-velocity clouds (HVCs) indicate, that they are
interacting with their ambient medium. Even clouds located in the very outer
Galactic halo or the intergalactic space seem to interact with their ambient
medium. In this paper, we investigate the dynamical evolution of high velocity
neutral gas clouds moving through a hot magnetized ambient plasma by means of
two-dimensional magnetohydrodynamic plasma-neutral gas simulations.
This situation is representative for the fast moving dense neutral gas
cloudlets in the Magellanic Stream as well as for high velocity clouds in
general. The question on the dynamical and thermal stabilization of a cold
dense neutral cloud in a hot thin ambient halo plasma is numerically
investigated. The simulations show the formation of a comet-like head-tail
structure combined with a magnetic barrier of increased field strength which
exerts a stabilizing pressure on the cloud and hinders hot plasma from
diffusing into the cloud.
The simulations can explain both the survival times in the intergalactic
medium and the existence of head-tail high velocity clouds.Comment: 11 pages, 19 figure
Shear-Flow Driven Current Filamentation: Two-Dimensional Magnetohydrodynamic Simulations
The process of current filamentation in permanently externally driven,
initially globally ideal plasmas is investigated by means of two-dimensional
Magnetohydrodynamic (MHD)-simulations. This situation is typical for
astrophysical systems like jets, the interstellar and intergalactic medium
where the dynamics is dominated by external forces. Two different cases are
studied. In one case, the system is ideal permanently and dissipative processes
are excluded. In the second case, a system with a current density dependent
resistivity is considered. This resistivity is switched on self-consistently in
current filaments and allows for local dissipation due to magnetic
reconnection. Thus one finds tearing of current filaments and, besides, merging
of filaments due to coalescence instabilities. Energy input and dissipation
finally balance each other and the system reaches a state of constant magnetic
energy in time.Comment: 32 Pages, 13 Figures. accepted, to appear in Physics of Plasmas
(049012
Robust Chauvenet Outlier Rejection
Sigma clipping is commonly used in astronomy for outlier rejection, but the
number of standard deviations beyond which one should clip data from a sample
ultimately depends on the size of the sample. Chauvenet rejection is one of the
oldest, and simplest, ways to account for this, but, like sigma clipping,
depends on the sample's mean and standard deviation, neither of which are
robust quantities: Both are easily contaminated by the very outliers they are
being used to reject. Many, more robust measures of central tendency, and of
sample deviation, exist, but each has a tradeoff with precision. Here, we
demonstrate that outlier rejection can be both very robust and very precise if
decreasingly robust but increasingly precise techniques are applied in
sequence. To this end, we present a variation on Chauvenet rejection that we
call "robust" Chauvenet rejection (RCR), which uses three decreasingly
robust/increasingly precise measures of central tendency, and four decreasingly
robust/increasingly precise measures of sample deviation. We show this
sequential approach to be very effective for a wide variety of contaminant
types, even when a significant -- even dominant -- fraction of the sample is
contaminated, and especially when the contaminants are strong. Furthermore, we
have developed a bulk-rejection variant, to significantly decrease computing
times, and RCR can be applied both to weighted data, and when fitting
parameterized models to data. We present aperture photometry in a contaminated,
crowded field as an example. RCR may be used by anyone at
https://skynet.unc.edu/rcr, and source code is available there as well.Comment: 62 pages, 48 figures, 7 tables, accepted for publication in ApJ
The critical velocity effect as a cause for the H\alpha emission from the Magellanic stream
Observations show significant H\alpha-emissions in the Galactic halo near the
edges of cold gas clouds of the Magellanic Stream. The source for the
ionization of the cold gas is still a widely open question. In our paper we
discuss the critical velocity effect as a possible explanation for the observed
H\alpha-emission. The critical velocity effect can yield a fast ionization of
cold gas if this neutral gas passes through a magnetized plasma under suitable
conditions. We show that for parameters that are typical for the Magellanic
Stream the critical velocity effect has to be considered as a possible
ionization source of high relevance.Comment: 9 pages, 2 figures. accepted, to appear in The Astrophysical Journa
Magneto-optical trapping of bosonic and fermionic neon isotopes and their mixtures: isotope shift of the ^3P_2 to ^3D_3 transition and hyperfine constants of the ^3D_3 state of Ne-21
We have magneto-optically trapped all three stable neon isotopes, including
the rare Ne-21, and all two-isotope combinations. The atoms are prepared in the
metastable ^3P_2 state and manipulated via laser interaction on the ^3P_2 to
^3D_3} transition at 640.2nm. These cold (T = 1mK) and environmentally
decoupled atom samples present ideal objects for precision measurements and the
investigation of interactions between cold and ultracold metastable atoms. In
this work, we present accurate measurements of the isotope shift of the ^3P_2
to ^3D_3 transition and the hyperfine interaction constants of the ^3D_3 state
of Ne-21. The determined isotope shifts are (1625.9\pm0.15)MHz for Ne-20 to
Ne-22, (855.7\pm1.0)MHz for Ne-20 to Ne-21, and (770.3\pm1.0)MHz for Ne-21 to
Ne-22. The obtained magnetic dipole and electric quadrupole hyperfine
interaction constants are A(^3D_3)= (-142.4\pm0.2)MHz and
B(^3D_3)=(-107.7\pm1.1)MHz, respectively. All measurements give a reduction of
uncertainty by about one order of magnitude over previous measurements
An Exploration of Communities of Practice in the STEM Teacher Context: What Predicts Ties of Retention?
The STEM teacher workforce in the United States has faced a host of pressing challenges, including teacher shortages, pervasive job dissatisfaction, and high turnover, problems largely attributable to working conditions within schools and districts. These problems have been exacerbated in high-needs districts with fewer resources and more students from low-income communities. Since social network research has shown that workplace relationships are vital for retention, this study investigates the demographic and relational antecedents to what we dub ties of retention. We explore how demographic and relational properties affect the likelihood that teachers have “retention-friendly” networks, characterized by connections important for retention. Our analysis of data from a sample of 120 STEM teachers across five geographic regions identifies key demographics (i.e., site, gender, career changer, and prior teaching experience) and relational properties (network size, positive affect, and perceptions of bridging) associated with ties of retention. We discuss the implications of our findings for the STEM teacher workforce and for teacher education programs
LC-HRMS data as a result of untargeted metabolomic profiling of human cerebrospinal fluid.
Cerebrospinal fluid (CSF) is a key body fluid that maintains the homeostasis in central nervous system (CNS). As a biofluid whose content reflects the brain metabolic activity, the CSF is analyzed in the context of neurological diseases and is rarely collected from healthy subjects. For this reason, the metabolite variation associated with general phenotypic characteristics such as gender and age have hardly ever been studied. Here we present the hydrophilic interaction liquid chromatography-high resolution mass spectrometry (HILIC-HRMS) data as a result of untargeted metabolomics analysis of a cohort of elderly cognitively healthy volunteers ( <i>n</i> = 32). 146 unambiguously identified water soluble metabolites (using accurate mass, retention time and MS/MS matching against spectral libraries) were measured and their abundances across all the subjects depending on their gender are provided in this article. Data tables are available at https://data.mendeley.com/datasets/c73xtsd4s5/1. it's published on mendeley, the DOI is DOI:10.17632/c73xtsd4s5.1. The data presented in this article are related to the research article entitled "A global HILIC-MS approach to measure polar human cerebrospinal fluid metabolome: Exploring gender-associated variation in a cohort of elderly cognitively healthy subjects" (Gallart-Ayala et al., 2018, In press)
In silico exploration of Red Sea Bacillus genomes for natural product biosynthetic gene clusters
Background: The increasing spectrum of multidrug-resistant bacteria is a major global public health concern, necessitating discovery of novel antimicrobial agents. Here, members of the genus Bacillus are investigated as a potentially attractive source of novel antibiotics due to their broad spectrum of antimicrobial activities. We specifically focus on a computational analysis of the distinctive biosynthetic potential of Bacillus paralicheniformis strains isolated from the Red Sea, an ecosystem exposed to adverse, highly saline and hot conditions. Results: We report the complete circular and annotated genomes of two Red Sea strains, B. paralicheniformis Bac48 isolated from mangrove mud and B. paralicheniformis Bac84 isolated from microbial mat collected from Rabigh Harbor Lagoon in Saudi Arabia. Comparing the genomes of B. paralicheniformis Bac48 and B. paralicheniformis Bac84 with nine publicly available complete genomes of B. licheniformis and three genomes of B. paralicheniformis, revealed that all of the B. paralicheniformis strains in this study are more enriched in nonribosomal peptides (NRPs). We further report the first computationally identified trans-acyltransferase (trans-AT) nonribosomal peptide synthetase/polyketide synthase (PKS/ NRPS) cluster in strains of this species. Conclusions:B. paralicheniformis species have more genes associated with biosynthesis of antimicrobial bioactive compounds than other previously characterized species of B. licheniformis, which suggests that these species are better potential sources for novel antibiotics. Moreover, the genome of the Red Sea strain B. paralicheniformis Bac48 is more enriched in modular PKS genes compared to B. licheniformis strains and other B. paralicheniformis strains. This may be linked to adaptations that strains surviving in the Red Sea underwent to survive in the relatively hot and saline ecosystems
Insight into the Mechanisms of Adenovirus Capsid Disassembly from Studies of Defensin Neutralization
Defensins are effectors of the innate immune response with potent antibacterial activity. Their role in antiviral immunity, particularly for non-enveloped viruses, is poorly understood. We recently found that human alpha-defensins inhibit human adenovirus (HAdV) by preventing virus uncoating and release of the endosomalytic protein VI during cell entry. Consequently, AdV remains trapped in the endosomal/lysosomal pathway rather than trafficking to the nucleus. To gain insight into the mechanism of defensin-mediated neutralization, we analyzed the specificity of the AdV-defensin interaction. Sensitivity to alpha-defensin neutralization is a common feature of HAdV species A, B1, B2, C, and E, whereas species D and F are resistant. Thousands of defensin molecules bind with low micromolar affinity to a sensitive serotype, but only a low level of binding is observed to resistant serotypes. Neutralization is dependent upon a correctly folded defensin molecule, suggesting that specific molecular interactions occur with the virion. CryoEM structural studies and protein sequence analysis led to a hypothesis that neutralization determinants are located in a region spanning the fiber and penton base proteins. This model was supported by infectivity studies using virus chimeras comprised of capsid proteins from sensitive and resistant serotypes. These findings suggest a mechanism in which defensin binding to critical sites on the AdV capsid prevents vertex removal and thereby blocks subsequent steps in uncoating that are required for release of protein VI and endosomalysis during infection. In addition to informing the mechanism of defensin-mediated neutralization of a non-enveloped virus, these studies provide insight into the mechanism of AdV uncoating and suggest new strategies to disrupt this process and inhibit infection
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